scholarly journals The Exposure of Fetuses and Children to Endocrine Disrupting Chemicals: A European Society for Paediatric Endocrinology (ESPE) and Pediatric Endocrine Society (PES) Call to Action Statement

2011 ◽  
Vol 96 (10) ◽  
pp. 3056-3058 ◽  
Author(s):  
Niels E. Skakkebaek ◽  
Jorma Toppari ◽  
Olle Söder ◽  
Catherine M. Gordon ◽  
Sara Divall ◽  
...  
Keyword(s):  
European Society ◽  
Endocrine Disrupting Chemicals ◽  
Clinical Work ◽  
Endocrine Disrupters ◽  
World Health ◽  
Endocrine Society ◽  
Paediatric Endocrinology ◽  
Endocrine Disrupting ◽  
Working Groups ◽  
Health Organization

Abstract Objective: During recent years, evidence has accumulated that both wildlife species and humans are exposed to ubiquitous endocrine-disrupting chemicals. Some are persistent in our bodies; others are nonpersistent but are produced in large quantities. Hitherto, the bulk of research in this area has been carried out by basic and experimental scientists and wildlife researchers. Relatively few clinical scientists have been engaged in research on this topic to date. The aim of this statement is to have pediatric endocrinologists consider the issue of endocrine disrupters in their clinical work and research. Participants: Six pediatric endocrinologists who belonged to working groups on endocrine disrupters endorsed by the European Society for Paediatric Endocrinology (ESPE) and the Pediatric Endocrine Society (PES) participated, including three members from each society. Meetings were limited to the members of the working groups. No funding was associated with the work. Evidence: Important data sources were publications from the World Health Organization, the European Science Foundation, and The Endocrine Society. Several of the participants have made long-standing contributions to the field of endocrine disruption. No unpublished work was considered. Consensus Process: The statement was written by the committee members together, using e-mail and phone. A draft was submitted to the Boards of the ESPE and PES. After some changes, the draft was accepted by both Boards. Conclusions: Pediatric endocrinologists are urged to be alert to the possible significance of endocrine-disrupting chemicals when assessing both clinical problems and research data where etiologies of endocrine symptoms or diseases are unknown.

scholarly journals Endocrine Disrupting Chemicals: Sources, Effects And Treatments

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Muhammad Aqeel Ashraf ◽  
Mesmire Wilson
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Environmental Chemicals ◽  
United Nations Environment Programme ◽  
World Health ◽  
Hormonal Changes ◽  
Endocrine Society ◽  
Endocrine Disrupting ◽  
Health Organization ◽  
International Experts

AbstractHormonal changes in humans and animals can be attributed to endocrine disrupting chemicals (EDCs). Studies have found that excessive exposure to natural and artificial environmental chemicals and toxins can have adverse effects on the endocrine system and reproductive health. The endocrine system creates and releases hormones that regulate the development of organs and how they function. Any disruption to hormones affects the development and functioning of the reproductive system, the brain and the neurological system. Research and reports on the subject have been published by international experts and organizations including the World Health Organization (WHO), United Nations Environment Programme (UNEP), International Labour Organization (ILO) and Endocrine Society. To fully comprehend the effect of EDCs on humans and wildlife, it is essential to understand epigenetics and its transgenerational effects on hormone development. Here, we extensively explore and review the research on the sources of EDCs, their effects and why exposure to EDCs is of concern, and treatments for EDC exposure.

scholarly journals Endocrine disrupting chemicals: Impact on human health, wildlife and the environment

2019 ◽  
Vol 102 (1) ◽  
pp. 3-42 ◽  
Author(s):  
Telma Encarnação ◽  
Alberto ACC Pais ◽  
Maria G Campos ◽  
Hugh D Burrows
Keyword(s):  
Human Health ◽  
Polybrominated Diphenyl Ethers ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
World Health ◽  
Endocrine Society ◽  
Endocrine Disrupting ◽  
Health Organization ◽  
Household Cleaning Products

Endocrine disrupting chemicals are a group of pollutants that can affect the endocrine system and lead to diseases and dysfunctions across the lifespan of organisms. They are omnipresent. They are in the air we breathe, in the food we eat and in the water we drink. They can be found in our everyday lives through personal care products, household cleaning products, furniture and in children’s toys. Every year, hundreds of new chemicals are produced and released onto the market without being tested, and they reach our bodies through everyday products. Permanent exposure to those chemicals may intensify or even become the main cause for the development of diseases such as type 2 diabetes, obesity, cardiovascular diseases and certain types of cancer. In recent years, legislation and regulations have been implemented, which aim to control the release of potentially adverse endocrine disrupting chemicals, often invoking the precautionary principle. The objective of this review is to provide an overview of research on environmental aspects of endocrine disrupting chemicals and their effects on human health, based on evidence from animal and human studies. Emphasis is given to three ubiquitous and persistent groups of chemicals, polychlorinated biphenyls, polybrominated diphenyl ethers and organochlorine pesticides, and on two non-persistent, but ubiquitous, bisphenol A and phthalates. Some selected historical cases are also presented and successful cases of regulation and legislation described. These led to a decrease in exposure and consequent minimization of the effects of these compounds. Recommendations from experts on this field, World Health Organization, scientific reports and from the Endocrine Society are included.

scholarly journals Endocrine disrupting chemicals vs longevity in the COVID-19 era: Public health implications

2020 ◽  
Vol 61 (2) ◽  
pp. 83-87
Author(s):  
Evangelos Polychronopoulos ◽  
George Balias ◽  
Maria Skouroliakou ◽  
Chrysa Kapartziani ◽  
Paraskevi Kalofiri ◽  
...  
Keyword(s):  
Public Health ◽  
Flame Retardants ◽  
Endocrine Disrupting Chemicals ◽  
Normal Function ◽  
World Health ◽  
Global Public Health ◽  
Endocrine Disrupting ◽  
Health Circles ◽  
Polycyclic Aromatic ◽  
Health Organization

Endocrine disrupting chemicals (EDCs) are a controversial topic within scientific, regulatory, socio-economic, and public health circles. Nonetheless, every community's physical environment is currently under siege from various EDCs, many of which are still unknown. EDCs affect the normal function of the endocrine, neurological, and immune systems, consequently diminishing successful development, reproductive adulthood, and decreasing survival. Beyond any doubt, adverse effects of EDCs are a consequence of multiple everyday exposures to hundreds of chemicals in unknown environmental doses such as pesticides, insecticides, polycyclic aromatic hydrocarbons, dioxins, polychlorinated biphenyls, dichlorodiphenyltrichloroethane, brominated flame retardants, and parabens. Considering that thousands of other known endocrine disruptors fly under the radar of scientific and medical communities due to existing methodological pitfalls, the situation is quite precarious. In 2012, the World Health Organization published a report emphasizing that EDCs are a major and emerging global public health threat. The combined power of informed consumers, industry innovations, and government regulations is the driving force in this fight. Therefore, research advancements, public health infrastructure, and environmental protection agencies are the fundamental pillars in combating the ever-growing issue of EDCs.

scholarly journals Communication tools in the COVID-19 era and beyond which can optimise professional practice and patient care

2020 ◽  
Vol 7 (1) ◽  
pp. 217-223
Author(s):  
Keiran David Clement ◽  
Eleanor F Zimmermann ◽  
Nikita R Bhatt ◽  
Alexander Light ◽  
Chuanyu Gao ◽  
...  
Keyword(s):  
Elective Surgery ◽  
Clinical Work ◽  
Healthcare Services ◽  
World Health ◽  
The Novel ◽  
Virtual Communication ◽  
Academic Settings ◽  
Pros And Cons ◽  
Health Organization ◽  
Detrimental Impact

Following the outbreak of the novel SARS-CoV-2 (COVID-19), the World Health Organization made a number of recommendations regarding the utilisation of healthcare services. In general, there has been a reduction in elective healthcare services including outpatient clinics, diagnostic services and elective surgery. Inevitably these reductions for all but the most urgent clinical work will have a detrimental impact on patients, and alternative ways of working including the use of telemedicine may help to mitigate this. Similarly, electronic solutions may enable clinicians to maintain inter and intra-professional working in both clinical and academic settings. Implementation of electronic solutions to minimise direct patient contact will be new to many clinicians, and the sheer number of software solutions available and varying functionality may be overwhelming to anyone unfamiliar with ‘virtual communication’. In this article, we will aim to summarise the variety of electronic communication platforms and tools available for clinicians and patients, detailing their utility, pros and cons, and some 'tips and tricks' from our experience through our work as an international research collaborative.

scholarly journals Breast Medical Oncology in the Era of COVID-19 Pandemic

2020 ◽  
Vol 5 (S1) ◽  
pp. 187-190
Author(s):  
Rania Chacha ◽  
Said Afqir
Keyword(s):  
Breast Cancer ◽  
World Health ◽  
Breast Cancer Patients ◽  
Negative Effects ◽  
Infected People ◽  
Cancer Management ◽  
Breast Cancer Management ◽  
Life Threatening ◽  
Working Groups ◽  
Health Organization

The coronavirus disease 2019 (COVID-19) has spread over the majority of countries and it was declared as a pandemic on March 11th, 2020 by The World Health Organization. The number of infected people worldwide is still in progress. Patients diagnosed with cancer are a fragile population because of their chronic disease and related treatments, and therefore, requiring a particular management. Several international initiatives from scientific societies and working groups have provided updated guidance to improve the medical treatments of breast cancer. These recommendations aimed to mitigate the negative effects of this outbreak on prevention, diagnosis, and treatments. Notably, this should be used for prioritizing the various aspects of cancer care particularly breast cancer patients’ safety. In this editorial, we shortly review the current guidelines for breast cancer management during this pandemic and illustrate the available treatments that should be prioritized. We believe this paper will be useful for young oncologists and physicians dealing with this emerging life-threatening disease.

scholarly journals Thresholds and Endocrine Disruptors: An Endocrine Society Policy Perspective

2020 ◽  
Vol 4 (10) ◽  
Author(s):  
Barbara Demeneix ◽  
Laura N Vandenberg ◽  
Richard Ivell ◽  
R Thomas Zoeller
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Standard Uncertainty ◽  
Hormone Action ◽  
Endocrine Society ◽  
Uncertainty Factors ◽  
Endocrine Disrupting ◽  
Adverse Effect Level ◽  
Effect Level ◽  
Development Proceeds ◽  
Regulatory Guideline

Abstract The concept of a threshold of adversity in toxicology is neither provable nor disprovable. As such, it is not a scientific question but a theoretical one. Yet, the belief in thresholds has led to traditional ways of interpreting data derived from regulatory guideline studies of the toxicity of chemicals. This includes, for example, the use of standard “uncertainty factors” when a “No Adverse Effect Level” (or similar “benchmark dose”) is either observed, or not observed. In the context of endocrine-disrupting chemicals (EDCs), this approach is demonstrably inappropriate. First, the efficacy of a hormone on different endpoints can vary by several orders of magnitude. This feature of hormone action also applies to EDCs that can interfere with that hormone. For this reason, we argue that the choice of endpoint for use in regulation is critical, but note that guideline studies were not designed with this in mind. Second, the biological events controlled by hormones in development not only change as development proceeds but are different from events controlled by hormones in the adult. Again, guideline endpoints were also not designed with this in mind, especially since the events controlled by hormones can be both temporally and spatially specific. The Endocrine Society has laid out this logic over several years and in several publications. Rather than being extreme views, they represent what is known about hormones and the chemicals that can interfere with them.

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