scholarly journals Bioavailability of Vitamin D in Malnourished Adolescents with Anorexia Nervosa

2011 ◽  
Vol 96 (8) ◽  
pp. 2575-2580 ◽  
Author(s):  
Amy D. DiVasta ◽  
Henry A. Feldman ◽  
Julia N. Brown ◽  
Courtney Giancaterino ◽  
Michael F. Holick ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Anorexia Nervosa ◽  
Body Mass ◽  
Young Women ◽  
Group Interaction ◽  
Control Group ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D

Abstract Context: Young women with anorexia nervosa (AN) have a normal vitamin D status. The bioavailability of vitamin D during malnutrition is unknown. Objective: The objective of the study was to examine the serum response to oral ergocalciferol in AN. Design/Setting: This was a prospective cohort study, conducted in 2007–2009 at a tertiary care center. Patients/Interventions: Twelve adolescents with AN (age 19.6 ± 2.0 yr, body mass index 16.5 ± 1.4 kg/m2) and 12 matched healthy controls (20.0 ± 2.4 yr, 22.7 ± 1.0 kg/m2) received one baseline 50,000 IU oral dose of ergocalciferol. Main Outcomes: Serum D2, D3, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D, collected before ingestion, at 6 and 24 h and weekly for 4 wk, and body composition measures were measured. Results: The AN group was severely malnourished (77.2 ± 6.3% median body weight), whereas the control group was normal weighted (106.2 ± 6.2%). From a common baseline D2 (1.5 ± 1.6 nmol/liter, P =0.34) the groups diverged (time × group interaction P = 0.04), peaking at 70 ± 34 nmol/liter at 6 h in controls compared with 43 ± 28 nmol/liter in AN subjects (P = 0.008). The D2 trajectories converged at 24 h (57 nmol/liter, P = 0.98) and returned to near baseline at 1 wk. Baseline D3 was higher in AN subjects (12.1 ± 9.6 vs. 3.1 ± 2.3 nmol/liter, P < 0.001) and remained higher throughout. 25-Hydroxyvitamin D followed a common trajectory (time × group interaction P = 0.15), rising to 45 ± 10 nmol/liter at 24 h but returning to baseline by wk 3 (P = 0.36). Correlating vitamin D levels with fat measures (body mass index, body fat) produced similar findings. Conclusions: Despite severe malnutrition, young women with AN had a similar bioavailability of oral ergocalciferol as the healthy-weighted controls. Vitamin D dosing for patients suffering from malnutrition may not differ from that for normal-weighted adolescents.

scholarly journals Sex and body mass index dependent associations between serum 25-hydroxyvitamin D and pulse pressure in middle-aged and older US adults

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jung Hyun Kwak ◽  
Yoon-Hyeong Choi
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Body Mass ◽  
Pulse Pressure ◽  
Lower Risk ◽  
Hydroxyvitamin D ◽  
Vascular Stiffening ◽  
25 Hydroxyvitamin D ◽  
Dose Dependent ◽  
Overweight Subjects

AbstractHigh pulse pressure (PP) is a valid indicator of arterial stiffness. Many studies have reported that vitamin D concentration is inversely associated with vascular stiffening. This association may differ depending on sex and body mass index (BMI). This study investigated the associations between vitamin D and PP and evaluated whether these associations differ according to sex and BMI, using data for individuals aged ≥ 50 years from the National Health and Nutrition Examination Survey (NHANES) 2007–2010. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were used as biomarkers of vitamin D levels. High PP was defined as ≥ 60 mmHg. Total 25(OH)D concentrations were dose-dependently associated with lower odds ratios (ORs) for high PP (p-trend = 0.01), after controlling for sociodemographic, behavioral, and dietary factors. When stratified by sex, there was a dose-dependent association between total 25(OH)D concentrations and lower risk of high PP (p-trend < 0.001) in females, but not in males. When stratified by BMI, there was a dose-dependent association between total 25(OH)D concentrations and lower risk of high PP (p-trend < 0.001) in non-overweight subjects, but not in overweight subjects. Improving the vitamin D status could delay elevation of PP and vascular stiffening in female and non-overweight subjects.

scholarly journals Correlation of Vitamin D and Body Mass Index in Term Normotensive and Pre -Eclamptic Women

2015 ◽  
Vol 3 (4) ◽  
pp. 21-25
Author(s):  
Taru Gupta ◽  
Nupur Gupta ◽  
Leena Wadhwa ◽  
Sarika Arora ◽  
Jyoti Bagla ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Body Mass ◽  
Serum Alkaline Phosphatase ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Maternal Body Mass Index ◽  
Study Group ◽  
Percentage Body Fat ◽  
Vitamin D Levels

INTRODUCTION: Obesity is associated with alteration in the vitamin D levels and has been related to vitamin D status. Lower vitamin D levels in higher BMI individuals may be secondary to an alteration in tissue distribution resulting from an increase in adipose mass. Therefore women with higher BMI need higher vitamin D supplementation as compared to women with BMI within normal range.  MATERIAL AND METHOD: This was a case control study carried out in Department of Obstetrics and Gynaecology, ESIC-PGIMSR, New Delhi from August 2012-April 2014. A total of 100 patients were divided into two equal groups (control and study groups of 50 each). Control group had women with singleton uncomplicated term normotensive pregnant women in labour while the study group comprised of term preeclamptic women in labour.In all the patients their BMI was analysed .Blood samples for vitamin D, serum calcium, serum phosphorus, serum parathormone, serum alkaline phosphatase levels were drawn and subsequently their levels were evaluated in cord blood; correlation studied between vitamin D & BMI. RESULTS: The mean BMI was relatively higher in the study group (26.34 ± 4.12)kg/m2 than in the control group ( 24.24 ± 3.13)kg/m2. Thus in our study a prevalence of higher BMI was seen in patients of preeclampsia. When all the 100 women are being considered, median vitamin D levels were found to be higher (6.6ng/ml) in normal BMI patients (n=55) as compared to levels (5.6ng/ml) in patients with higher BMI(n=45).  CONCLUSION: Vitamin D levels are related to maternal body mass index. Individuals with higher percentage body fat may require higher vitamin D intake to attain optimal 25(OH) D levels, compared with lean individuals and thereby may prevent pregnancy complications like Pre eclampsia.

scholarly journals Evaluation of Maternal Serum 25-Hydroxyvitamin D Levels in Patients with Hyperemesis Gravidarum at Early Gestational Weeks

2020 ◽  
Vol 9 (3) ◽  
pp. 123-130
Author(s):  
Burcu Kayılı ◽  
Muhammet Ali Oruç ◽  
Yasemin Alan ◽  
Murat Alan ◽  
Deniz Can Öztekin
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Hyperemesis Gravidarum ◽  
Control Group ◽  
Hydroxyvitamin D ◽  
Severe Deficiency ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
The Mean

Aim: The aim of this study was to compare vitamin D levels between pregnant women with hyperemesis gravidarum before 12 weeks of gestation and healthy pregnant women at similar ages. Methods: Sixty pregnancies with hyperemesis gravidarum and 60 age compatible healthy pregnancies applied to our facility were included in the study. Demographic characteristics, maternal thyroid function tests and 25-Hydroxyvitamin D levels were evaluated. Student t test was used for the variables with normal distribution and Mann-Whitney U test was used to analyze the variables without normal distribution. Results: Only one pregnant woman had normal vitamin D levels (>30ng/ml), whereas 71 patients had deficiency (10-30 ng/ml), and 48 had severe deficiency (<10 ng/ml). The mean vitamin D level of the total 120 pregnancies was 11.9±5.00 ng/ml (9.92±3.67 ng/ml in case group, 13.88±5.38 ng/ml in control group). The mean value of vitamin D was found to be significantly lower in hyperemesis gravidarum. 45% (n=27) of the pregnant women had vitamin D deficiency, whereas 55% (n=33) of them had severe deficiency. Free T3 and T4 levels were significantly higher than the control group, and thyroid-stimulating hormone level was significantly lower. Conclusion: Vitamin D levels of pregnant women with hyperemesis gravidarum were significantly lower. Vitamin D deficiency should be considered in patients with hyperemesis gravidarum. Keywords: pregnancy, hyperemesis gravidarum, Vitamin D deficiency

scholarly journals The Impact of Serum 25-Hydroxyvitamin D3 Levels on Allergic Rhinitis

2019 ◽  
pp. 014556131987431 ◽  
Author(s):  
Kübra Çoban ◽  
Işılay Öz ◽  
Deniz İlhan Topçu ◽  
Erdinç Aydın
Keyword(s):  
Vitamin D ◽  
Allergic Rhinitis ◽  
Serum Levels ◽  
Control Group ◽  
Study Group ◽  
Hydroxyvitamin D ◽  
Median Serum ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
Skin Prick Tests

We aimed to clarify the relation between allergic rhinitis and the serum levels of 25-hydroxivitamin D in the adult population. The study group consisted of 86 patients with allergic rhinitis who were diagnosed with the help of history of allergy, positive signs for allergy, blood samples, and positive skin prick tests; while the control group included 43 age- and sex-matched healthy volunteers with negative skin prick tests. The demographic data, medical history, findings in the physical examinations, serum levels of total immunoglobulin E (IgE) and 25-hydroxyvitamin D, and skin prick test results of the groups were noted. A total of 129 patients fulfilling the necessary criteria were enrolled. The median serum 25-hydroxyvitamin D levels in the study group were significantly lower compared to the control group ( P = .014). In the study group, median serum vitamin D levels were significantly higher in men, compared to women ( P = .03). There was a significant negative correlation between IgE and vitamin D levels in the allergic rhinitis group ( P = .028, r = −0.246). This study showed that patients with allergic rhinitis might be more vulnerable to have lower serum levels of vitamin D. Thus, vitamin D supplementation as an adjunctive therapy may be considered in those patients.

scholarly journals Evaluation of vitamin D levels and body mass indexes of university employees

2020 ◽  
Vol 19 (2) ◽  
pp. 229-236
Author(s):  
Murat Emrah MAVİŞ ◽  
Çiğdem YILDIRIMMAVİŞ ◽  
İrem ÖZAY ARANCIOĞLU ◽  
Hatice Kübra YILMAZ ◽  
Berrak ERGÜDEN ◽  
...  
Keyword(s):  
Vitamin D ◽  
Body Mass ◽  
Anthropometric Measurement ◽  
University Employees ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
25 Hydroxyvitamin D ◽  
Body Mass Indexes ◽  
The Relationship

Objective: Vitamin D is known to have important effects on human health. The existence of a relationship between obesity and vitamin D levels, which have been shown to cause a number of health problems with various studies, is certain. In this study, the relationship between vitamin D levels and body mass indexes(BMI) of individuals was evaluated. The study is unique for being the only research on literature that carried out with university employees. Materials and methods: Blood samples, anthropometric measurement (BMI) was obtained from 87 volunteer working at Haliç University. The questionnaire form covering the basic questions applied by means of face-to-face method. Quantification of the analytes for 25-hydroxyvitamin-D was carried out using LC-MS/MS. The relationship between 25-hydroxyvitamin-D values and BMI was evaluated with Tukey HSD multiple comparison test. 95% confidence and 80% power sampling were applied to the predictions of a minimum0.50 connection coefficient between 2 quantitative variables.The necessity of 30 cases was determined by using the N = [(Zα+Zβ)/C]2 + 3formula.Considering the losses, the work will be carried out over 80 people. Results and Discussion: There’s significant difference between 25-hydroxyvitamin-D2 and 25-hydroxyvitamin-D3 and the BMI levels of the subjects(p:0.028<0.05-p:0.000<0.05). The average 25-hydroxyvitamin-D3 and 25-hydroxyvitamin-D2 levels of overweight participants were significantly higher than the mean levels of underweight participants’. No significant relationship was found between 25-hydroxyvitamin-D3 and 25-hydroxyvitamin-D2 levels and the time spent outdoors during summer and winter. Conclusion: To prevent vitamin D deficiency and insufficiency is to obtain some sensible sun exposure, ingest foods that contain vitamin D, and take supplement. Bangladesh Journal of Medical Science Vol.19(2) 2020 p.229-236

scholarly journals Study on Serum Vitamin D in Alopecia Areata Patients

2019 ◽  
Vol 17 (01) ◽  
pp. 21-25
Author(s):  
Suchana Marahatta ◽  
Sudha Agrawal ◽  
Seraj Khan
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Alopecia Areata ◽  
Serum Vitamin ◽  
Control Group ◽  
Healthy Controls ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D

Background: Alopecia areata is the commonest cause of non-scarring alopecia. Few previous studies have found correlation between AA and vitamin D deficiency, suggesting that vitamin D deficiency can be a risk factor for Alopecia areata. To compare serum vitamin D level between Alopecia areata patients and healthy controls; and to assess the relation between serum vitamin D levels and AA disease severity.Methods: This case control study included 30 newly diagnosed Alopecia areata patients. Thorough history was taken, detail examination was done and relevant findings were recorded in the standardized pro-forma. Their serum vitamin D (25-hydroxyvitamin D) levels were determined by competitive chemiluminescence methods; and were compared with that of age and sex matched healthy controls. Chi square test and Spearman’s rho correlation test were used for the inferential statistics using SPSS version 11.5. Results: There were 30 AA patients with mean age 28.37+10.07 years. Mean Severity of Alopecia Tool score was 3.56+3.50. Prevalence of 25-hydroxyvitamin D [25(OH)D] deficiency was significantly higher in AA group (83.3%) compared to the control group (53.3%) (P=0.01). Similarly, serum 25(OH)D level was reduced more in Alopecia areata group (12.84, IQR=8.87-20.47) than the control group (29.5, IQR=19.85-41.27) (P=0.06). There was inverse co-relation between serum 25(OH)D level and SALT score.Conclusions: Prevalence of serum 25(OH)D deficiency was significantly higher in Alopecia areata group compared to the control, with inverse co-relation between its level and Alopecia areata disease severity. Keywords: Alopecia areata; Nepal; SALT Score; Vitamin D.

scholarly journals Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3442
Author(s):  
Alicja Kołodziejczyk-Nowotarska ◽  
Renata Bokiniec ◽  
Joanna Seliga-Siwecka
Keyword(s):  
Vitamin D ◽  
Preterm Infants ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
Ultrasound Findings ◽  
25 Hydroxyvitamin D ◽  
To Receive

Appropriate supplementation of vitamin D can affect infections, allergy, and mental and behavioral development. This study aimed to assess the effectiveness of monitored vitamin D supplementation in a population of preterm infants. 109 preterm infants (24 0/7–32 6/7 weeks of gestation) were randomized to receive 500 IU vitamin D standard therapy (n = 55; approximately 800–1000 IU from combined sources) or monitored therapy (n = 54; with an option of dose modification). 25-hydroxyvitamin D [25(OH)D] concentrations were measured at birth, 4 weeks of age, and 35, 40, and 52 ± 2 weeks of post-conceptional age (PCA). Vitamin D supplementation was discontinued in 23% of infants subjected to standard treatment due to increased potentially toxic 25(OH)D concentrations (>90 ng/mL) at 40 weeks of PCA. A significantly higher infants’ percentage in the monitored group had safe vitamin D levels (20−80 ng/mL) at 52 weeks of PCA (p = 0.017). We observed increased vitamin D levels and abnormal ultrasound findings in five infants. Biochemical markers of vitamin D toxicity were observed in two patients at 52 weeks of PCA in the control group. Inadequate and excessive amounts of vitamin D can lead to serious health problems. Supplementation with 800–1000 IU of vitamin D prevents deficiency and should be monitored to avoid overdose.

scholarly journals The influence of body mass index and renin–angiotensin–aldosterone system activity on the relationship between 25-hydroxyvitamin D and adiponectin in Caucasian men

2011 ◽  
Vol 164 (6) ◽  
pp. 995-1002 ◽  
Author(s):  
Anand Vaidya ◽  
John P Forman ◽  
Patricia C Underwood ◽  
Paul N Hopkins ◽  
Gordon H Williams ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Body Mass ◽  
Dietary Sodium ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
Hydroxyvitamin D ◽  
Caucasian Men ◽  
25 Hydroxyvitamin D ◽  
The Relationship

ObjectivePrevious studies have suggested that circulating adiponectin concentrations are associated positively with vitamin D and negatively with body mass index (BMI) but have not accounted for the influence of the renin–angiotensin–aldosterone system (RAAS) in this relationship. This is particularly relevant because increased RAAS activity is associated with obesity and is known to lower adiponectin levels. We evaluated the association between adiponectin and 25-hydroxyvitamin D (25(OH)D) after controlling RAAS activity with dietary sodium equilibration and also evaluated whether this relationship was influenced by BMI.DesignCross-sectional study of 115 hypertensive Caucasian men from the Hypertensive Pathotype Consortium.MethodsTo manipulate RAAS activity, all subjects underwent 1 week of high dietary sodium (HS) diet to suppress RAAS and 1 week of low dietary sodium (LS) diet to stimulate RAAS. Linear regression was used to evaluate the association between adiponectin and 25(OH)D, and the effect of BMI on this relationship, in each dietary condition.ResultsAdiponectin was higher on HS, where circulating RAAS activity was low, when compared with LS (HS=2.9 versus LS=2.4 μg/ml, P<0.0001). 25(OH)D levels were positively associated with adiponectin, and BMI was a statistically significant effect modifier of the relationship between 25(OH)D and adiponectin on both diets (P interaction <0.01 between BMI and 25(OH)D).ConclusionsHigher 25(OH)D concentrations were independently associated with higher adiponectin levels, particularly when BMI was high. Dietary sodium balance and circulating RAAS activity did not appear to affect this relationship. Future studies should explore whether vitamin D supplementation increases adiponectin levels in obesity.

scholarly journals Association of serum 25-hydroxyvitamin D with prevalence, incidence, and clearance of vaginal HPV infection in young women

2020 ◽  
Author(s):  
Mariam El-Zein ◽  
Farzin Khosrow-Khavar ◽  
Ann N Burchell ◽  
Pierre-Paul Tellier ◽  
Shaun Eintracht ◽  
...  
Keyword(s):  
Vitamin D ◽  
Proportional Hazards ◽  
Hpv Infection ◽  
Cox Proportional Hazards ◽  
Baseline Serum ◽  
Hpv Dna ◽  
Hydroxyvitamin D ◽  
Hpv Prevalence ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D

Abstract Background We assessed the association between serum 25-hydroxyvitamin D levels and genital human papillomavirus (HPV) prevalence, incidence, and clearance among female participants of the HITCH cohort study. Methods We genotyped HPV DNA in vaginal samples and quantified baseline serum 25-hydroxyvitamin D levels using Roche’s Linear Array and Total vitamin D assay, respectively. We used logistic and Cox proportional hazards models to respectively estimate adjusted odds ratios (OR) and hazards ratios (HR) with 95% confidence intervals (CI). Results There was no association between vitamin D levels (every 10ng/mL increase) at baseline and HPV prevalence (OR=0.88, CI:0.73-1.03) or incidence (HR=0.88, CI:0.73-1.06), but we observed a modest negative association with HPV clearance (HR=0.76, CI:0.60-0.96). Vitamin D levels &lt;30ng/mL, compared to ≥30ng/mL, were not associated with HPV prevalence (OR=0.98, CI:0.57-1.69) or incidence (HR=0.87, CI:0.50-1.43), but were associated with a marginally significant increased clearance (OR=2.14, CI:0.99-4.64). We observed consistent results with restricted cubic spline modelling of vitamin D levels and clinically defined categories. HPV type-specific analyses accounting for multiple HPV infections per participant showed no association between vitamin D levels and all study outcomes. Conclusion This study provided no evidence of an association between low vitamin D levels and increased HPV prevalence, acquisition, or clearance.

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