scholarly journals Early Endotoxemia Increases Peripheral and Hepatic Insulin Sensitivity in Healthy Humans

2009 ◽  
Vol 94 (2) ◽  
pp. 463-468 ◽  
Author(s):  
Saskia N. van der Crabben ◽  
Regje M. E. Blümer ◽  
Michiel E. Stegenga ◽  
Mariëtte T. Ackermans ◽  
Erik Endert ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Hepatic Insulin Sensitivity ◽  
Healthy Humans

scholarly journals Effects of fructose overfeeding on intrahepatic lipid accumulation and hepatic insulin sensitivity in healthy humans

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Virgile Lecoultre ◽  
Leonie Egli ◽  
Andreas Boss ◽  
Guillaume Carrel ◽  
Fanny Theytaz ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Lipid Accumulation ◽  
Hepatic Insulin Sensitivity ◽  
Healthy Humans ◽  
Intrahepatic Lipid

scholarly journals Effects of fructose and glucose overfeeding on hepatic insulin sensitivity and intrahepatic lipids in healthy humans

Obesity ◽  
2013 ◽  
Vol 21 (4) ◽  
pp. 782-785 ◽  
Author(s):  
V. Lecoultre ◽  
L. Egli ◽  
G. Carrel ◽  
F. Theytaz ◽  
R. Kreis ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Hepatic Insulin Sensitivity ◽  
Healthy Humans ◽  
Intrahepatic Lipids

Lower Hepatic Insulin Sensitivity in a Family with a Recently Described Glucokinase Gene Variant

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1509-P ◽  
Author(s):  
KÁLMÁN BÓDIS ◽  
OANA P. ZAHARIA ◽  
YANISLAVA KARUSHEVA ◽  
PAVEL BOBROV ◽  
DANIEL F. MARKGRAF ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Gene Variant ◽  
Glucokinase Gene ◽  
Hepatic Insulin Sensitivity

Exenatide Treatment Improves Mitochondrial Metabolism and Hepatic Insulin Sensitivity in Mice with Nonalcoholic Steatohepatitis (NASH)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1846-P
Author(s):  
SRILAXMI KALAVALAPALLI ◽  
FERNANDO BRIL ◽  
ARIANA VERGARA ◽  
NISHANTH SUNNY ◽  
KENNETH CUSI
Keyword(s):  
Insulin Sensitivity ◽  
Nonalcoholic Steatohepatitis ◽  
Mitochondrial Metabolism ◽  
Hepatic Insulin Sensitivity

Regulation of Hepatic Insulin Sensitivity and Hepatic Steatosis by ULK1

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1863-P ◽  
Author(s):  
YOUNGDO KOO ◽  
MICHAEL P. GARNEAU ◽  
QUANJIANG ZHANG ◽  
E. DALE ABEL
Keyword(s):  
Insulin Sensitivity ◽  
Hepatic Steatosis ◽  
Hepatic Insulin Sensitivity

scholarly journals Regulation of Mitochondria-Associated Membranes (MAMs) by NO/sGC/PKG Participates in the Control of Hepatic Insulin Response

Cells ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 1319 ◽  
Author(s):  
Arthur Bassot ◽  
Marie-Agnès Chauvin ◽  
Nadia Bendridi ◽  
Jingwei Ji-Cao ◽  
Guillaume Vial ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Insulin Signaling ◽  
Soluble Guanylate Cyclase ◽  
Insulin Response ◽  
Cyclophilin D ◽  
Hepatic Insulin Sensitivity ◽  
Physiological Conditions ◽  
Huh7 Cells ◽  
The Impact

Under physiological conditions, nitric oxide (NO) produced by the endothelial NO synthase (eNOS) upregulates hepatic insulin sensitivity. Recently, contact sites between the endoplasmic reticulum and mitochondria named mitochondria-associated membranes (MAMs) emerged as a crucial hub for insulin signaling in the liver. As mitochondria are targets of NO, we explored whether NO regulates hepatic insulin sensitivity by targeting MAMs. In Huh7 cells, primary rat hepatocytes and mouse livers, enhancing NO concentration increased MAMs, whereas inhibiting eNOS decreased them. In vitro, those effects were prevented by inhibiting protein kinase G (PKG) and mimicked by activating soluble guanylate cyclase (sGC) and PKG. In agreement with the regulation of MAMs, increasing NO concentration improved insulin signaling, both in vitro and in vivo, while eNOS inhibition disrupted this response. Finally, inhibition of insulin signaling by wortmannin did not affect the impact of NO on MAMs, while experimental MAM disruption, using either targeted silencing of cyclophilin D or the overexpression of the organelle spacer fetal and adult testis-expressed 1 (FATE-1), significantly blunted the effects of NO on both MAMs and insulin response. Therefore, under physiological conditions, NO participates to the regulation of MAM integrity through the sGC/PKG pathway and concomitantly improves hepatic insulin sensitivity. Altogether, our data suggest that the induction of MAMs participate in the impact of NO on hepatocyte insulin response.

scholarly journals Measurement of hepatic insulin sensitivity early after the bypass of the proximal small bowel in humans

2016 ◽  
Vol 3 (1) ◽  
pp. 95-98 ◽  
Author(s):  
A. D. Miras ◽  
R. Herring ◽  
A. Vusirikala ◽  
F. Shojaee‐Moradi ◽  
N. C. Jackson ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Small Bowel ◽  
Hepatic Insulin Sensitivity ◽  
Proximal Small Bowel
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