scholarly journals Effect of an Estrogen Receptor-α Intron 4 Polymorphism on Fat Mass in 11-Year-Old Children

2007 ◽  
Vol 92 (6) ◽  
pp. 2286-2291 ◽  
Author(s):  
J. H. Tobias ◽  
C. D. Steer ◽  
C. Vilariňo-Güell ◽  
M. A. Brown
Keyword(s):  
Estrogen Receptor ◽  
Body Composition ◽  
Body Fat ◽  
Fat Mass ◽  
Genetic Effect ◽  
Estrogen Receptor Α ◽  
Body Fat Mass ◽  
Cross Sectional ◽  
Total Body Fat ◽  
Total Body

Abstract Context: Polymorphisms in the ESR1 gene encoding estrogen receptor (ER)-α may be associated with fat mass in adults. Objectives: The objective of the study was to establish whether ESR1 polymorphisms influence fat mass in childhood. Design: This was a cross-sectional analysis after genotyping of rs9340799, rs2234693, and rs7757956 ESR1 polymorphisms. Setting: The Avon Longitudinal Study of Parents and Children (ALSPAC) was a population-based prospective study. Participants: Participants included 3097 11-yr-old children with results for ESR1 genotyping, puberty measures, and dual-energy x-ray absorptiometry results. Outcomes: Relationships between ESR1 polymorphisms and indices of body composition were measured. Results: The rs7757956 polymorphism was associated with fat mass (P = 0.002). Total body fat mass (adjusted for height) was reduced by 6% in children with TA/AA genotypes, and risk of being overweight (≥85th centile of fat mass) was decreased by 20%. This genetic effect appeared to interact with puberty in girls (P = 0.05 for interaction): in those with the TT genotype, total body fat mass (adjusted for height) was 18% higher in Tanner stages 3–5 vs. stages 1–2; the equivalent difference was 7% in those with TA/AA genotypes. Furthermore, the risk of being overweight was 36% lower in girls with TA/AA genotypes in Tanner stages 3–5, but no reduction was seen in those in stages 1–2. Neither rs9340799 nor rs2234693 polymorphisms were associated with body composition measures. Conclusions: Fat mass in 11-yr-old children was related to the rs7757956 ESR1 polymorphism. This association was strongest in girls in more advanced puberty, in whom the risk of being overweight was reduced by 36% in those with the TA/AA genotype.

Bivariate whole-genome linkage scan for bone geometry and total body fat mass

2009 ◽  
Vol 36 (2) ◽  
pp. 89-97 ◽  
Author(s):  
Shufeng Lei ◽  
Feiyan Deng ◽  
Peng Xiao ◽  
Kai Zhong ◽  
Hongyi Deng ◽  
...  
Keyword(s):  
Body Fat ◽  
Fat Mass ◽  
Bone Geometry ◽  
Body Fat Mass ◽  
Whole Genome ◽  
Total Body Fat ◽  
Total Body

scholarly journals Prediction of the <i>in vivo</i> Body Composition of Pigs Based on Cross- Sectional Region Analysis of Dual Energy X-Ray Absorptiometry (DXA) Scans

2002 ◽  
Vol 45 (6) ◽  
pp. 535-545
Author(s):  
A. D. Mitchell ◽  
A. Scholz ◽  
V. Pursel
Keyword(s):  
Body Composition ◽  
Chemical Analysis ◽  
Body Fat ◽  
The Body ◽  
Cross Sectional ◽  
Body Protein ◽  
Total Body Fat ◽  
Total Body ◽  
Dxa Scans

Abstract. The purpose of this study was to evaluate the use of a cross-sectional scan as an alternative to the total body DXA scan for predicting the body composition of pigs in vivo. A total of 212 pigs (56 to 138 kg live body weight) were scanned by DXA. The DXA scans were analyzed for percentage fat and lean in the total body and in 14 cross-sections (57.6 mm wide): 5 in the front leg/thoracic region, 4 in the abdominal region, and 5 in the back leg region. Regression analysis was used to compare total body and cross-sectional DXA results and chemical analysis of total body fat, protein and water. The relation (R2) between the percentage fat in individual slices and the percentage of total body fat measured by DXA ranged from 0.78 to 0.97 and by chemical analysis from 0.71 to 0.85, respectively. The relation between the percentage of lean in the individual slices and chemical analysis for percentage of total body protein and water ranged from 0.48 to 0.60 and 0.56 to 0.76, respectively. These results indicate that total body composition of the pig can be predicted (accurately) by performing a time-saving single-pass cross-sectional scan.

scholarly journals Relationship of total body fat mass to weight-bearing bone volumetric density, geometry, and strength in young girls

Bone ◽  
2010 ◽  
Vol 46 (4) ◽  
pp. 977-984 ◽  
Author(s):  
Joshua N. Farr ◽  
Zhao Chen ◽  
Jeffrey R. Lisse ◽  
Timothy G. Lohman ◽  
Scott B. Going
Keyword(s):  
Body Fat ◽  
Fat Mass ◽  
Weight Bearing ◽  
Body Fat Mass ◽  
Volumetric Density ◽  
Young Girls ◽  
Total Body Fat ◽  
Total Body ◽  
Bone Volumetric Density ◽  
Relationship Of

scholarly journals Impact of a lignan-rich diet on adiposity and insulin sensitivity in post-menopausal women

2009 ◽  
Vol 102 (2) ◽  
pp. 195-200 ◽  
Author(s):  
Anne-Sophie Morisset ◽  
Simone Lemieux ◽  
Alain Veilleux ◽  
Jean Bergeron ◽  
S. John Weisnagel ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Body Fat ◽  
Fat Mass ◽  
Metabolic Profile ◽  
Body Fat Mass ◽  
Dietary Record ◽  
Menopausal Women ◽  
Total Body Fat ◽  
Total Body ◽  
Post Menopausal

There has been a growing interest in lignans, a class of phyto-oestrogens, because of their potentially favourable effects on human health. The aim of the present study was to compare the metabolic profile of post-menopausal women consuming various amounts of dietary lignans. Phyto-oestrogen intake was assessed using a 3-d dietary record analysed with a Canadian food phyto-oestrogen content data table in 115 post-menopausal women (age 56·8 (sd 4·4) years and BMI 28·5 (sd 5·9) kg/m2). Plasma enterolactone (ENL), the major biologically active metabolite of dietary lignans, was determined by time-resolved fluoroimmunoassay. Anthropometrics, abdominal adipose tissue areas (computed tomography), body composition (hydrostatic weighing) and insulin sensitivity (hyperinsulinaemic–euglycaemic clamp) were measured in all women. Women in the high dietary lignan intake subgroup (n 29) had a significantly lower BMI and total body fat mass, as well as a better glucose disposal rate (GDR; P < 0·05), compared with women in the low lignan intake subgroup (n 28). The majority of women with the highest dietary lignan intake were also in the highest quartile of plasma ENL (59 %). Women in the highest ENL quartile had a significantly lower BMI (26·1 (sd 4·4) v. 30·4 (sd 6·9) kg/m2, P < 0·05), total body fat mass (24·8 (sd 9·8) v. 33·3 (sd 13·3) kg, P < 0·05), 2 h postload glycaemia (5·5 (sd 0·9) v. 5·7 (sd 0·8) nmol/l, P < 0·05) and a higher GDR (8·3 (sd 2·7) v. 5·5 (sd 2·8), P < 0·01) compared with women in the lowest ENL quartile. In conclusion, women with the highest ENL concentrations had a better metabolic profile including higher insulin sensitivity and lower adiposity measures.

scholarly journals Changes in body composition and leptin levels during growth hormone (GH) treatment in short children with various GH secretory capacities

1999 ◽  
pp. 35-42 ◽  
Author(s):  
H Matsuoka ◽  
H Fors ◽  
I Bosaeus ◽  
S Rosberg ◽  
K Albertsson-Wikland ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Fat ◽  
Fat Mass ◽  
Gh Treatment ◽  
Deconvolution Analysis ◽  
Serum Leptin ◽  
Gh Secretion ◽  
Short Children ◽  
Total Body Fat ◽  
Total Body

OBJECTIVE: The aim of this study was to follow changes in body composition, estimated by dual-energy X-ray absorptiometry (DXA), in relation to changes in leptin during the first year of GH therapy in order to test the hypothesis that leptin is a metabolic signal involved in the regulation of GH secretion in children. DESIGN AND METHODS: In total, 33 prepubertal children were investigated. Their mean (S.D.) chronological age at the start of GH treatment was 11.5 (1.6) years, and their mean height was -2.33 (0.38) S.D. scores (SDS). GH was administered subcutaneously at a daily dose of 0.1 (n=26) or 0.2 (n=7) IU/kg body weight. Ten children were in the Swedish National Registry for children with GH deficiency, and twenty-three children were involved in trials of GH treatment for idiopathic short stature. Spontaneous 24-h GH secretion was studied in 32 of the children. In the 24-h GH profiles, the maximum level of GH was determined and the secretion rate estimated by deconvolution analysis (GHt). Serum leptin levels were measured at the start of GH treatment and after 10 and 30 days and 3, 6 and 12 months of treatment. Body composition measurements, by DXA, were performed at baseline and 12 months after the onset of GH treatment. RESULTS: After 12 months of GH treatment, mean height increased from -2.33 to -1.73 SDS and total body fat decreased significantly by 3.0 (3.3)%. Serum leptin levels were decreased significantly at all time points studied compared with baseline. There was a significant correlation between the change in total body fat and the change in serum leptin levels during the 12 months of GH treatment, whereas the leptin concentration per unit fat mass did not change. In a multiple stepwise linear regression analysis with 12 month change in leptin levels as the dependent variable, the percentage change in fat over 12 months, the baseline fat mass (%) of body mass and GHt accounted for 24.0%, 11.5% and 12.2% of the variability respectively. CONCLUSIONS: There are significant correlations between changes in leptin and fat and endogenous GH secretion in short children with various GH secretory capacities. Leptin may be the messenger by which the adipose tissue affects hypothalamic regulation of GH secretion.

Hematological changes in anorexia nervosa are correlated with total body fat mass depletion

1997 ◽  
Vol 21 (4) ◽  
pp. 329-334 ◽  
Author(s):  
Michel Lambert ◽  
Catherine Hubert ◽  
Genevi�ve Depresseux ◽  
Bruno Vande Berg ◽  
Jean-Paul Thissen ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Body Fat ◽  
Fat Mass ◽  
Body Fat Mass ◽  
Total Body Fat ◽  
Mass Depletion ◽  
Total Body ◽  
Hematological Changes

scholarly journals POS0570 ASSOCIATION OF BODY FAT MASS AND ITS DISTRIBUTION WITH DISEASE ACTIVITY, PAIN AND DISABILITY IN RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 519.2-520
Author(s):  
O. Lamkhanat ◽  
H. Azzouzi ◽  
I. Linda
Keyword(s):  
Rheumatoid Arthritis ◽  
Body Composition ◽  
Disease Activity ◽  
Body Fat ◽  
Fat Mass ◽  
Health Assessment ◽  
Cross Sectional Study ◽  
Body Fat Mass ◽  
Obese Patients ◽  
Cross Sectional

Background:Rheumatoid arthritis (RA) and body composition are closely related. Recent studies have found a significant association between fat mass and disease activity and disability in RA [1].Objectives:We aimed to study the association between body fat mass and its distribution with disease activity, disability, and pain in RA patients.Methods:This is a cross-sectional study of patients with RA diagnosis according to ACR-EULAR 2010 classification recruited from first January 2021. Those with prior cancer, hyperparathyroidism, hyperthyroidism, diabetes, chronic kidney disease, and cirrhosis were excluded. Body fat mass (BFM) and its distribution (gynoid (GFM), android (AFM), visceral (VFM), limbs (LFM), trunk (TFM)) were measured with dual-energy X-ray absorptiometry (Hologic, Horizon QDR®). Clinical data and laboratory tests of the same day of the DXA scan were analyzed. The associations between BFM and its distribution with disease activity score (DAS28CRP), pain visual analogue scale (VAS), and disability measured by health assessment questionnaire (HAQ) were explored. Obesity was defined as a body mass index (BMI) ≥ of 25kg/m2. Our statistical analysis was based on descriptive study, comparisons and linear regressions using SPSS 20.Results:It is about 69 RA patients. Their mean age was 49.86 ± 14.33 years, mean DAS28CRP was 2.56 ± 1.27, and mean disease duration was 14.84 ± 10.99 years. Sixty-two (89.9%) were women. The mean BMI was 26.46 ± 5.26 kg/m2, and 41 patients were obese (59.4%). Compared with non-obese patients, obese patients had a higher C-reactive protein (p = 0.03). DAS28CRP was higher in obese patients (2.77 ± 1.41 vs 2.25 ± 0.97) but did not reach significance (p = 0.07). We did not find any difference between the two groups regarding pain and disability. In univariate regression analysis, the LFM was positively associated with disease activity (p = 0.001; β = 0.38), pain (p = 0.001; β = 0.38) and disability (p = 0.007; β = 0.32). Adjusted on BMI, LDL cholesterol, triglyceride, cumulative dose of corticosteroid, disease and corticosteroid duration, menopause duration, dose and duration of methotrexate, we found a significant association between LFM, disability (p = 0.02; β = 0.51), disease activity (p = 0.02; β = 0.54) and pain (p = 0.009; β = 0.57). However, we had no association between disease activity, pain, and disability with BFM and the other components.Conclusion:Limbs fat mass was significantly associated with the activity, disability, and pain in RA patients.References:[1]Kyeong Min Son, Seong Hun Kang, Young Il Seo, Hyun Ah Kim. Association of body composition with disease activity and disability in rheumatoid arthritis. Korean J Intern Med. 2021 Jan;36(1):214-222.Disclosure of Interests:None declared

Identification of high bone mass; a syndrome characterised by mandible enlargement, an inability to float and increased total body fat mass

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S227
Author(s):  
C. Gregson ◽  
N. Crabtree ◽  
S. Steel ◽  
K. Poole ◽  
E. McCloskey ◽  
...  
Keyword(s):  
Bone Mass ◽  
Body Fat ◽  
Fat Mass ◽  
Body Fat Mass ◽  
High Bone Mass ◽  
Total Body Fat ◽  
High Bone ◽  
Total Body
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