scholarly journals Water Drinking Induces Thermogenesis through Osmosensitive Mechanisms

2007 ◽  
Vol 92 (8) ◽  
pp. 3334-3337 ◽  
Author(s):  
Michael Boschmann ◽  
Jochen Steiniger ◽  
Gabriele Franke ◽  
Andreas L. Birkenfeld ◽  
Friedrich C. Luft ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Healthy Subjects ◽  
Crossover Trial ◽  
Normal Weight ◽  
Gastric Distension ◽  
Men And Women ◽  
Water Drinking ◽  
Randomized Controlled ◽  
Response To Water ◽  
Thermogenic Response

Abstract Context: Recently, we showed that drinking 500 ml water induces thermogenesis in normal-weight men and women. Objective: We now repeated these studies in a randomized, controlled, crossover trial in overweight or obese otherwise healthy subjects (eight men and eight women), comparing also the effects of 500 ml isoosmotic saline or 50 ml water. Results: Only 500 ml water increased energy expenditure by 24% over the course of 60 min after ingestion, whereas isoosmotic saline and 50 ml water had no effect. Heart rate and blood pressure did not change in these young, healthy subjects. Conclusions: Our data exclude volume-related effects or gastric distension as the mediator of the thermogenic response to water drinking. Instead, we hypothesize the existence of a portal osmoreceptor, most likely an ion channel.

Effect of adding milk to black tea on vascular function in healthy men and women: a randomised controlled crossover trial

2018 ◽  
Vol 9 (12) ◽  
pp. 6307-6314 ◽  
Author(s):  
Adilah F. Ahmad ◽  
Lisa Rich ◽  
Henrietta Koch ◽  
Kevin D. Croft ◽  
Mario G. Ferruzzi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vascular Function ◽  
Crossover Trial ◽  
Black Tea ◽  
Tea Consumption ◽  
Short Term ◽  
Men And Women ◽  
Healthy Men ◽  
Randomised Controlled ◽  
P Addition

Addition of milk to black tea alters the acute/short-term benefical effect of regular black tea consumption on vascular function and blood pressure.

Gastric distension attenuates the hypotensive effect of intraduodenal glucose in healthy older subjects

2008 ◽  
Vol 295 (2) ◽  
pp. R472-R477 ◽  
Author(s):  
Diana Gentilcore ◽  
James H. Meyer ◽  
Christopher K. Rayner ◽  
Michael Horowitz ◽  
Karen L. Jones
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Gastric Emptying ◽  
Healthy Subjects ◽  
Hypotensive Effect ◽  
Gastric Distension ◽  
Two Dimensional ◽  
Current Management ◽  
Older Subjects ◽  
Hypotensive Response

Postprandial hypotension occurs frequently, and current management is suboptimal. Recent studies suggest that the magnitude of the fall in postprandial blood pressure (BP) may be attenuated by gastric distension. The aim of this study was to determine the effect of gastric distension on the hypotensive response to intraduodenal (ID) glucose. Eight healthy subjects (5 males, 3 females, aged 65–76 years) received an ID infusion of either 1) 50 g glucose in 300 ml saline (ID glucose) over 60 min ( t = 0–60 min), 2) 50 g glucose in 300 ml saline over 60 min and intragastric ( 4 ) infusion of 500 ml water between t = 7–10 min (IG water and ID glucose), or 3) ID saline (0.9%) infusion over 60 min and IG infusion of 500 ml water (IG water and ID saline) all followed by ID saline infusion for another 60 min ( t = 60–120 min) on three separate days. BP and heart rate (HR) were measured. Gastric emptying (GE) of the IG water was quantified by two-dimensional ultrasonography. Between t = 0–60 min, systolic and diastolic BP was greater ( P < 0.05 for both) with IG water and ID saline compared with IG water and ID glucose, and less ( P < 0.05 for both) with ID glucose compared with IG water and ID glucose. These effects were evident at relatively low IG volumes (∼300 ml). GE was faster with IG water and ID saline when compared with IG water and ID glucose. We conclude that, in healthy older subjects, IG administration of water markedly attenuates the hypotensive response to ID glucose, presumably as a result of gastric distension.

scholarly journals Nitrate-rich vegetables do not lower blood pressure in individuals with mildly elevated blood pressure: a 4-wk randomized controlled crossover trial

2018 ◽  
Vol 107 (6) ◽  
pp. 894-908 ◽  
Author(s):  
Lauren C Blekkenhorst ◽  
Joshua R Lewis ◽  
Richard L Prince ◽  
Amanda Devine ◽  
Nicola P Bondonno ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Crossover Trial ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Lower Blood Pressure ◽  
Randomized Controlled ◽  
Lower Blood

scholarly journals The osmopressor response to water drinking

2011 ◽  
Vol 300 (1) ◽  
pp. R40-R46 ◽  
Author(s):  
Marcus May ◽  
Jens Jordan
Keyword(s):  
Healthy Subjects ◽  
Transient Receptor Potential ◽  
Pressor Response ◽  
Resting Energy Expenditure ◽  
Receptor Potential ◽  
Normal Weight ◽  
Water Drinking ◽  
Neurally Mediated Syncope ◽  
Transduction Mechanisms ◽  
Transient Receptor

Water drinking elicits profound pressor responses in patients with impaired baroreflex function and in sinoaortic-denervated mice. Healthy subjects show more subtle changes in heart rate and blood pressure with water drinking. The water-induced pressor response appears to be mediated through sympathetic nervous system activation at the spinal level. Indeed, water drinking raises resting energy expenditure in normal weight and obese subjects. The stimulus setting off the response is hypoosmolarity rather than water temperature or gastrointestinal stretch. Studies in mice suggest that this osmopressor response may involve transient receptor potential vanniloid 4 (Trpv4) receptors. However, the (nerve) cell population serving as peripheral osmosensors and the exact transduction mechanisms are still unknown. The osmopressor response can be exploited in the treatment of orthostatic and postprandial hypotension in patients with severe autonomic failure. Furthermore, the osmopressor response acutely improves orthostatic tolerance in healthy subjects and in patients with neurally mediated syncope. The phenomenon should be recognized as an important confounder in cardiovascular and metabolic studies.

Water drinking improves orthostatic tolerance in patients with posturally related syncope

2006 ◽  
Vol 110 (3) ◽  
pp. 343-352 ◽  
Author(s):  
Victoria E. Claydon ◽  
Christoph Schroeder ◽  
Lucy J. Norcliffe ◽  
Jens Jordan ◽  
Roger Hainsworth
Keyword(s):  
Blood Pressure ◽  
Cerebral Blood Flow Velocity ◽  
Peripheral Resistance ◽  
Orthostatic Tolerance ◽  
Lower Body ◽  
Water Drinking ◽  
Randomized Controlled ◽  
Combined Test ◽  
Time Required ◽  
The Relationship

Water drinking improves OT (orthostatic tolerance) in healthy volunteers; however, responses to water in patients with PRS (posturally related syncope) are unknown. Therefore the aim of the present study was to examine whether water would improve OT in patients with PRS. In a randomized controlled cross-over fashion, nine patients with PRS ingested 500 ml and 50 ml (control) of water 15 min before tilting on two separate days. OT was determined using a combined test of head-up tilting and lower body suction and expressed as the time required to induce presyncope. We measured blood pressure and heart rate (using Portapres®) and middle cerebral artery velocity (using transcranial Doppler). SV (stroke volume) and TPR (total peripheral resistance) were calculated using the Modelflow® method. OT was significantly (P<0.02) greater after drinking 500 ml of water than after 50 ml (25.4±1.5 compared with 19.8±2.3 min respectively). After ingestion of 500 ml of water, blood pressure during tilting was higher, the tiltinduced reduction in SV was smaller and the increase in TPR was greater (all P<0.05). The correlation coefficient of the relationship between cerebral blood flow velocity and pressure was lower after 500 ml of water (0.43±0.1 compared with 0.73±0.1; P<0.05), indicating better autoregulation. In conclusion, drinking 500 ml of water increased OT and improved cardiovascular and cerebrovascular control during orthostasis. Patients with PRS should be encouraged to drink water before situations likely to precipitate a syncopal attack.

scholarly journals Impact of nasogastric tubes on swallowing physiology in older, healthy subjects: A randomized controlled crossover trial

2015 ◽  
Vol 34 (4) ◽  
pp. 572-578 ◽  
Author(s):  
Lee N. Pryor ◽  
Elizabeth C. Ward ◽  
Petrea L. Cornwell ◽  
Stephanie N. O'Connor ◽  
Mark E. Finnis ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Crossover Trial ◽  
Randomized Controlled ◽  
Nasogastric Tubes
Sign in / Sign up

Export Citation Format

Share Document