scholarly journals The Impact of Glucocorticoid Replacement Regimens on Metabolic Outcome and Comorbidity in Hypopituitary Patients

2006 ◽  
Vol 91 (10) ◽  
pp. 3954-3961 ◽  
Author(s):  
Helena Filipsson ◽  
John P. Monson ◽  
Maria Koltowska-Häggström ◽  
Anders Mattsson ◽  
Gudmundur Johannsson
Keyword(s):  
Body Mass Index ◽  
Total Cholesterol ◽  
Body Mass ◽  
Metabolic Response ◽  
Glycosylated Hemoglobin ◽  
Density Lipoprotein ◽  
Gh Treatment ◽  
Igf I ◽  
Before And After ◽  
The Impact

Abstract Background: Hypopituitary patients with untreated GH deficiency and patients on inappropriately high doses of glucocorticoid (GC) share certain clinical features. Objective: The aim of the study was to examine the influence of GC substitution on clinical characteristics in hypopituitary patients before and after GH replacement therapy. Method: A total of 2424 hypopituitary patients within the KIMS (Pfizer International Metabolic Database) were grouped according to ACTH status. Comparisons were performed between subjects on hydrocortisone (HC) (n = 1186), cortisone acetate (CA) (n = 487), and prednisolone/dexamethasone (n = 52), and ACTH-sufficient patients (AS) (n = 717) before and after 1 yr of GH treatment in terms of body mass index, waist and hip circumference, blood pressure, glucose, glycosylated hemoglobin (HbA1c), serum lipids, IGF-I, and comorbidity. Hydrocortisone equivalent (HCeq) doses were calculated, and measurements were adjusted for sex and age. Results: At baseline, the HC group had increased total cholesterol, triglycerides, waist circumference, and HbA1c, and the prednisolone/dexamethasone group had increased waist/hip ratio as compared with AS. After HCeq dose adjustment, the HC group retained higher HbA1c than the CA group. GC-treated patients showed a dose-related increase in serum IGF-I, body mass index, triglycerides, low-density lipoprotein cholesterol and total cholesterol levels. Subjects with HCeq doses less than 20 mg/d (n = 328) at baseline did not differ from AS in metabolic endpoints. The 1-yr metabolic response to GH was similar in all GC groups and dose categories. All new cases of diabetes (n = 12), stroke (n = 8), and myocardial infarction (n = 3) during GH treatment occurred in GC-treated subjects. Conclusion: HCeq doses of at least 20 mg/d in adults with hypopituitarism are associated with an unfavorable metabolic profile. CA replacement may have metabolic advantages compared with other GCs.

scholarly journals Hubungan indeks massa tubuh dengan profil lipid pada pasien diabetes melitus tipe 2

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Pradika H. Koampa ◽  
Karel Pandelaki ◽  
Marthen C.P. Wongkar
Keyword(s):  
Body Mass Index ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Body Mass ◽  
Pearson Correlation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Diabetes Melitus

Abstract: Body Mass Index (BMI) is a measurement of nutritional status by calculating the ratio of height and weight. Type 2 Diabetes Mellitus (T2DM) is more common in a person with a BMI of more than normal. In patients with T2DM, there is lipid metabolism disorder, dyslipidaemia. Changes in lipid profiles consist of increased levels of total cholesterol, Low Density Lipoprotein (LDL), and triglycerides, and decreased levels of High Density Lipoprotein (HDL). This study aimed to obtain the correlation between body mass index and lipid profile in T2DM patients in Prof. Dr. R. D. Kandou Hospital Manado. This was a descriptive analytical study using patients’ medical record in Endocrine Clinic Prof. Dr. R. D. Kandou Hospital Manado from September to November 2015. The Pearson correlation test showed correlations between BMI and total cholesterol levels with r=0.037and p=0.763; between BMI and HDL levels with r=-0.249 and p=0.039; between BMI and LDL levels with r=0.091 and p=0,455; and between BMI and triglyceride levels with r=0.179 and p=0.142. Conclusion: Among T2DM patients, there were no significant correlations between body mass index and total cholesterol, LDL cholesterol, as wello as triglyceride levels. However, there was a significant correlation between body mass index and HDL levels. Keywords: body mass index, total cholesterol, HDL, LDL, triglycerides, T2DM Abstrak: Indeks Massa Tubuh (IMT) merupakan salah satu pengukuran status gizi dengan menghitung perbandingan tinggi badan dan berat badan. Diabetes Melitus Tipe 2 (DMT2) lebih sering terjadi pada individu dengan IMT lebih dari normal. Pada pasien DMT2 terjadi gangguan metabolisme lipid yaitu dislipidemia. Perubahan profil lipid yang terjadi yaitu peningkatan kadar Kolesterol Total, Low Density Lipoprotein (LDL), dan trigliserida, serta penurunan kadar High Density Lipoprotein (HDL). Penelitian ini bertujuan untuk mengetahui hubungan antara IMT dengan profil lipid pada pasien DMT2di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ini deskriptif analitik dengan menggunakan data rekam medik pasien di Poliklinik Endokrin Bagian/SMF Ilmu Penyakit Dalam RSUP. Prof. Dr. R. D. Kandou Manado periode September – November 2015. Hasil uji korelasi Pearson memperlihatkan nilai hubungan antara IMT dan kadar kolesterol total r = 0,037 dan p = 0,763 ; nilai hubungan antara IMT dan kadar HDL r = -0,249 dan p = 0,039 ; nilai hubungan antara IMT dan kadar LDL r = 0,091 dan p = 0,455; serta nilai hubungan antara IMT dan kadar trigliserida r = 0,179 dan p = 0,142. Simpulan: Pada pasien DMT2 tidak dijumpai hubungan bermakna antara IMT dengan kadar kolesterol total, kadar LDL, dan kadar trigliserida, namun terdapat hubungan bermakna antara IMT dengan kadar HDL.Kata kunci: IMT, kolesterol total, HDL, LDL, trigliserida, DMT2

scholarly journals Metabolic changes after bariatric surgical procedures

2020 ◽  
Vol 2 (1) ◽  
pp. 14-31
Author(s):  
Mohammed Ahmed ◽  
Saad Hummady ◽  
Falih ALgazgoos
Keyword(s):  
Body Mass Index ◽  
Lipid Profile ◽  
Body Mass ◽  
Surgical Procedures ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Glycosylated Hemoglobin ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Independent Effect

Introduction: Obesity is associated with diabetes, dyslipidemia and increased cardiovascular disease risks. Bariatric surgeries are one of the most reliable ways to treat obesity. Bariatric Surgical procedures started in Basra at 2009 and since then, thousands of surgeries had been made, mainly in Al-Sadr Teaching Hospital. Objective: To prospectively evaluate the short term effect of bariatric surgical procedures on body mass index (BMI), lipid profile and glycosylated hemoglobin (HbA1C) and compare the effects of various types of these surgical procedures. Methods: A 12-month prospective study on 73 patients who underwent three types of bariatric surgeries, laparoscopic sleeve gastrectomy surgery (LSG), laparoscopic REUX-EN-Y gastric bypass surgery (LRYGB) and minigastric bypass surgery (MGB). Body mass index (BMI), HbA1C, total cholesterol (TC), High-Density-Lipoprotein cholesterol (HDL), Low-Density-Lipoprotein cholesterol (LDL) and triglycerides (TG) levels were evaluated before surgery and at 3 and 6 months postoperatively. Results: All bariatric procedures show significant improvement in all parameters (increment in HDL, reduction in BMI, A1C, HDL, LDL, TC, TG) at 3 months that continue to improve more at 6 months postoperatively (p<0.001), however, bypass surgeries (LRYGB and MGB) has additional favorable independent effect on A1C and LDL seen at 6 months post operatively. Conclusion: All of the studied bariatric surgeries improve BMI, HbA1C and lipid profile significantly, however, bypass procedures have more effect on LDL and HbA1C that seem to be procedure related and independent from weight loss or other changes.

scholarly journals Factors associated with serum lipids of adolescents from the Brazilian South

2014 ◽  
Vol 27 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Carmem Cristina Beck ◽  
Adair da Silva Lopes ◽  
José Cazuza de Farias Júnior
Keyword(s):  
Body Mass Index ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Body Mass ◽  
High Density Lipoprotein Cholesterol ◽  
Serum Lipids ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Factors Associated ◽  
Independent Variables

OBJECTIVE: This study analyzes factors associated with serum lipids in adolescents from southern Brazil. METHODS: This is a school-based cross-sectional study with a probabilistic sample composed of 660 adolescents aged 14 to 19 years from the city of Três de Maio, Rio Grande do Sul state, Brazil. The following independent variables were analyzed: body mass index; waist-to-height ratio; moderate to vigorous level of physical activity; sedentary behaviour; lipid, total saturated fatty acid, cholesterol, sodium, and fiber intakes; smoking; and alcohol abuse. Linear regression analysis tested the association between the independent variables and total cholesterol and high density lipoprotein-cholesterol. RESULTS: Body mass index was directly associated with total cholesterol (β=0.96, p=0.001) and reversely associated with high density lipoprotein-cholesterol (β=-0.45, p<0.001). CONCLUSION: High body mass index may have a negative impact on the lipid profile of adolescents. Thus, monitoring nutritional status is important to prevent and control dyslipidemia in adolescents. We suggest multidisciplinary and intersectoral actions that encourage teenagers to acquire a healthy lifestyle, with emphasis on the adoption of an active lifestyle and balanced diet.

scholarly journals CLOCK 3111TT Genotype Is Associated with Increased Total Cholesterol and Low-Density Lipoprotein Levels in Menopausal Women with a Body Mass Index of at Least 25 kg/m2

2020 ◽  
Vol 28 (1) ◽  
pp. 1-9
Author(s):  
Natalya Semenova ◽  
Irina Madaeva ◽  
Sergey Kolesnikov ◽  
Lyubov Rychkova ◽  
Tatjana Bairova ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Gene Polymorphism ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Body Mass ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Minor Allele ◽  
Low Density ◽  
Menopausal Women

Lipid profile comparative analysis was performed to reveal the interdependence of lipids with Circadian locomoter output cycles protein kaput (CLOCK) 3111T/C gene polymorphism in menopausal women with/without a body mass index (BMI) of ≥25 kg/m2. Methods: A total of 193 female volunteers aged 45 to 60 years were divided into two groups: Those with BMI < 25 kg/m2 (control) and those with BMI ≥ 25 kg/m2. Each group was then divided into two subgroups: Those with the CLOCK TT-genotype and those with the CLOCK TC-, CC-genotypes. Lipid metabolism parameters were determined by the enzymatic method. Single-nucleotide polymorphisms (SNPs) were detected via polymerase chain reaction–restriction fragment length polymorphism technology. Results: There were no differences in CLOCK 3111T/C genotypes or allele frequency between the control and main groups. In addition, there were no differences in lipid profile parameters between women of the control group and different CLOCK 3111T/C genotypes. The total cholesterol (p = 0.041) and low-density lipoprotein cholesterol (p = 0.036) levels were higher in the subgroup of women with a BMI ≥ 25 kg/m2 and CLOCK TT-genotype as compared to the subgroup with a BMI ≥ 25 kg/m2 and minor allele 3111C. Conclusions: SNP 3111T/C of the CLOCK gene is not associated with BMI however, data suggest that the minor allele of the CLOCK 3111T/C gene polymorphism may have a protective role in atherogenic lipid levels in women with a BMI greater than or equal to 25 kg/m2.

Abstract 39: Added Sugar Intake and Lipids Profile Among US Adolescents: NHANES 2005-2010

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Zefeng Zhang ◽  
Cathleen Gillespie ◽  
Frank Hu ◽  
Quanhe Yang
Keyword(s):  
Body Mass Index ◽  
Measurement Error ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Body Mass ◽  
Density Lipoprotein ◽  
High Density ◽  
Added Sugar ◽  
Race Ethnicity ◽  
Lipids Profile

Background: Studies suggest that higher consumption of added sugar is associated with cardiovascular risk factors in adolescents. However, these studies were subject to measurement error due to the lack of adjustment for day-to-day variability. Hypothesis: We hypothesized that higher usual percent of calories from added sugar is associated with dyslipidemia. Methods: We analyzed data on 3322 adolescents aged 12-19 years who were not on low fat/low cholesterol diet or on sugar free/low sugar diet from the 2005-2010 National Health and Nutrition Examination Surveys. We estimated the usual percent of calories from added sugar from the diet accounting for measurement error. Multivariable linear regression was used to examine the associations between the percent of calories from added sugar with lipids profile. Results: The average usual percent of calories from added sugar was 17.5%. Ninety-one percent and 11% adolescents had usual percent ≥10% and ≥25%, respectively. After adjustment for potential confounders (age, sex, race/ethnicity, body mass index, parental educational attainment, smoking status, physical activity, 2010 Health Eating Index score except sugar component, and total calorie intake), usual percent of calories from added sugar was inversely associated with high-density lipoprotein and positively associated with triglycerides and the ratio of total cholesterol to high-density lipoprotein. Among the lowest and the highest quintiles of intake, high-density lipoprotein were 52.4 mg/dL (95% CI: 50.9 to 53.9) and 49.0 (95% CI: 47.9 to 50.2) (P trend = 0.003), triglycerides were 80.2 mg/dL (95% CI: 70.5 to 90.0) and 100.4 mg/dL (95% CI: 86.7 to 114.2) (P trend = 0.028), and the ratio of total cholesterol to high-density lipoprotein were 3.16 (95% CI: 2.8 to 3.6) and 3.49 (95% CI: 3.0 to 4.0) (P trend =0.006), respectively. The patterns of association were largely consistent across gender, race/ethnicity, and body mass index (normal vs. overweight/obese) subgroups, except in non-Hispanic black and Mexican American, in which the magnitude of the association tended to be smaller. Sensitivity analysis showed that, when intake data from the 1 st 24-hour dietary recall was used, the association remained significant but attenuated substantially. No association was found for total cholesterol and low-density lipoprotein. Conclusions: Overwhelming majority of US adolescents consumed more added sugar than recommended for heart health. Increased intake of added sugar is associated with several measures of dyslipidemia, and reduction of added sugar consumption among adolescents might reduce the risk of developing cardiovascular disease in adults.

scholarly journals Long-Term Burden of Increased Body Mass Index from Childhood on Adult Dyslipidemia: The i3C Consortium Study

2019 ◽  
Vol 8 (10) ◽  
pp. 1725 ◽  
Author(s):  
Yinkun Yan ◽  
Lydia A. Bazzano ◽  
Markus Juonala ◽  
Olli T. Raitakari ◽  
Jorma S. A. Viikari ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Early Life ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Lipid Lowering ◽  
Lipid Levels ◽  
Increased Risk ◽  
The Impact

Background: Data are limited regarding the association of cumulative burden and trajectory of body mass index (BMI) from early life with adult lipid disorders. Methods: The study cohort consisted of 5195 adults who had BMI repeatedly measured 4 to 21 times from childhood and had blood lipid measurements of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) and information on lipid-lowering medications in the last adult survey. The area under the curve (AUC) was calculated as a measure of long-term burden (total AUC) and trends (incremental AUC) of BMI. Results: Participants with dyslipidemia, high LDL-C, low HDL-C and high TG had consistently and significantly higher BMI levels from childhood to adulthood compared to those with normal lipid levels. After adjusting for age, race, sex, and cohort, increased risk of adult dyslipidemia was significantly associated with higher values of childhood BMI, adulthood BMI, total AUC and incremental AUC, with odds ratio (95% confidence interval) = 1.22 (1.15–1.29), 1.85 (1.74–1.97), 1.61 (1.52–1.71), and 1.59 (1.50–1.69), respectively, and p < 0.001 for all. The association patterns were similar in most race–sex subgroups. Conclusions: Adults with dyslipidemia versus normal lipid levels have consistently higher levels and distinct life-course trajectories of BMI, suggesting that the impact of excessive body weight on dyslipidemia originates in early life.

scholarly journals Long term effects of a ketogenic diet with Mav Ketofast pro supplements in obese postmenopausal women

2017 ◽  
Vol 1 (1) ◽  
pp. 33
Author(s):  
Maria Vranceanu
Keyword(s):  
Body Mass Index ◽  
Bone Density ◽  
Total Cholesterol ◽  
Postmenopausal Women ◽  
Ketogenic Diet ◽  
Body Mass ◽  
Fat Mass ◽  
Hdl Cholesterol ◽  
Before And After ◽  
Fat Mass Loss

Background: The aim of this study was to determine the effects of a 24 weeks    ketogenic diet with MaV Ketofast pro supplement in obese postmenopausal women. Methods: In the present study, 22 obese postmenopausal women with a body mass index greater than 35 kg/m2 and high glucose, high cholesterol and high       triglycerides levels were selected. Anthropometric measurements evaluated were: height, weight, BMI, waist circumferences and FM (fat mass) baseline and after 12 weeks and 24 weeks. Total cholesterol, high density lipoprotein (HDL) cholesterol, triglycerides and fasting blood sugar were determined before and after the       administration of the ketogenic diet. The bone density score before and after    treatment has been evaluated. The patients ages varied from 52 to 68 years (with a mean age of 60.04 years). The average weight at the start of treatment for all patients was 105.27 kg. The initial BMI average was 39.2 kg/m2, initial FM=48.7% and waist circumference 130.04 cm. Results After 24 weeks of a ketogenic diet with MaV   Ketofast pro supplement the group lost an average of 19.87 kg. Fat mass loss was 10.8% and waist circumference decreased 22.04 cm. Body mass index of the patients decreased significantly. The level of total cholesterol decreased from week 1 to week 24, HDL cholesterol levels significantly increased and the level of triglycerides   decreased significantly following 24 weeks of treatment. The level of blood glucose significantly decreased. The changes in the level of bone density were not statistically significant. Conclusions: The present study demonstrates the beneficial effects of a long-term ketogenic diet in obese postmenopausal women. The KD (ketogenic diet) with Mav ketofast pro supplement significantly reduced the body weight and body mass index of the patients and increased the fat mass loss. Furthermore, it decreased the level of triglycerides, total cholesterol and blood glucose, and increased the level of HDL cholesterol. Administering a ketogenic diet for a relatively longer period of time did not produce any significant side effects in the patients. The bone density didn’t change during the ketogenic diet that means the diet it is safe and helpful for postmenopausal women.

scholarly journals Correlation of lipids and lipoprotein concentration with body mass index in obese, overweight and normal weight south Indian adults

2017 ◽  
Vol 5 (11) ◽  
pp. 4803
Author(s):  
Gayathri B. ◽  
Vinodhini V. M.
Keyword(s):  
Body Mass Index ◽  
Total Cholesterol ◽  
Body Mass ◽  
Density Lipoprotein ◽  
Public Health Problem ◽  
Cardiac Risk ◽  
Normal Weight ◽  
Research Centre ◽  
College Hospital ◽  
South Indian

Background: Obesity a chronic disorder is gradually becoming a serious public health problem in many countries. The aim of the study was designed to measure serum lipids and lipoproteins as marker for cardiovascular disease among obese and overweight South Indian adults.Methods: The study was done between June 2016 to December 2016, in SRM medical college hospital and research centre, Kattankulathur which comprised of 270 participants of both gender in the age of 18- 55 years. 90 individuals with body mass index (BMI ≥25kg/m2), 90 individuals with BMI in the range of 23.0 to 24.99kg/m2 and 90 age and sex matched controls (BMI = 18 to 22.99kg/m2) were selected for the study. Serum levels of total cholesterol, Triacylglycerol, high density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) were analyzed by using auto analyzer Beckman Coulter AU480. The cardiac risk ratio 1 (cholesterol/HDL-C ratio) and 2 (LDL-C/HDL-C) ratio were calculated.Results: The difference between the mean values of total cholesterol, triglycerides and LDL-C, were found to be statistically significant across the three groups. Positive correlation was observed between BMI and cardiac risk ratios one and two in both obese and overweight groups.Conclusions: Cardiac risk is increased in South Indian overweight and obese individuals which is evident from the elevated levels of total cholesterol, triglycerides, LDL-C and cardiac rick ratio one (cholesterol/HDL-C ratio) and two (LDL-C/HDL-C).

scholarly journals ASSOCIATION OF LIPID PROFILE WITH BODY MASS INDEX IN GALL STONE DISEASE

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
Dr. Pravin Shirke ◽  
Dr. Suryakant Nagtilak
Keyword(s):  
Body Mass Index ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Body Mass ◽  
Gall Stone ◽  
Density Lipoprotein ◽  
College Teaching ◽  
Stone Disease ◽  
Gall Stones ◽  
Gall Stone Disease

Introduction: Gall stone disease is common in northern regions of India including Uttarakhand. It is traditionally seen in fat, fertile, female of fourty. Apart from this, age, obesity, hyperlipidemia, smoking & diabetes are other risk factors. Gall stones show more association with elevated levels of triglyceride and low high density lipoprotein (HDL-C) where less association with total cholesterol and low density lipoprotein (LDL-C). Increased prevalence of gall stone reported in overweight. This present study conducted with an aim to find out the co-relation of lipid profile, BMI (body mass index) and gall stones in Uttarakhand population attending Shridev Suman Subharti Medical College Teaching Hospital, Dehradun. Material & Methods: Total 120 patients (10 M, 110 F) were included in the study following confirmation of diagnosis of gall stones on ultrasound. Age, sex, dietary habits, occupation, medical history and drug history of each patient were recorded in predesigned, tested proforma. The BMI calculated as weight in Kg/height in meter square. BMI of 18 to 24.9 were regarded as normal, whereas, 25 to 29.9 as overweight, 30 to 39.9 as obese and above 40 as morbid obese. The serum cholesterol, LDL, HDL and Triglyceride were estimated on a fasting sample by keeping patient nil orally for 12hrs after their normal meal. Results: Out of total 120 patients, 110(91.67%) were female & 10(8.33%) were male, with female to male ratio 9:1. The age-group of 21 to 40 years was the most common, with 64(53.33%) patients belonging to this group. Triglyceride was raised in 35(29.17%) patients, total cholesterol was raised in 7(5.83%) patients and LDL was raised in 5(4.17%) patients. The cholesterol was lowered in 13(10.83%) patients, HDL was lowered in 8(6.66%) patients and triglyceride was lowered in 3(2.5%) patients. Triglyceride & LDL were raised in 4(3.3%) patients, cholesterol and triglyceride were raised in 3(2.5%) patients and cholesterol and HDL were lowered in 4 (3.33%) patients. Patients with BMI of 18.0-24.9 were 72(60.00%), BMI of 25-29.9 were 36(30.00%) and BMI of 30-39.9 were 9(7.50%) respectively. Conclusion: The present study on presence of Gall stones which are more commonly found in females aged 21 to 40 years. Raised levels of Triglyceride and lower levels of cholesterol are associated with gall stones. There is no association between Increased BMI & presence of gall stones. BMI is associated with higher level of   Triglyceride. Key Words: Gall stone, BMI, Triglyceride, Cholesterol, and HDL-C.

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