scholarly journals Nerve Growth Factor-Dependent Activation of trkA Receptors in the Human Ovary Results in Synthesis of Follicle-Stimulating Hormone Receptors and Estrogen Secretion

2006 ◽  
Vol 91 (6) ◽  
pp. 2396-2403 ◽  
Author(s):  
C. Salas ◽  
M. Julio-Pieper ◽  
M. Valladares ◽  
R. Pommer ◽  
M. Vega ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Hormone Receptors ◽  
Follicle Stimulating Hormone ◽  
Human Ovary ◽  
Nerve Growth ◽  
Trka Receptors ◽  
Stimulating Hormone

scholarly journals Umbilical Cord Mesenchymal Stem Cell Transplantation Prevents Chemotherapy-Induced Ovarian Failure via the NGF/TrkA Pathway in Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Qun Zheng ◽  
Xiaoyan Fu ◽  
Jinzhan Jiang ◽  
Ning Zhang ◽  
Libo Zou ◽  
...  
Keyword(s):  
Stem Cell ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Mesenchymal Stem Cell ◽  
Umbilical Cord ◽  
Caspase 3 ◽  
Follicle Stimulating Hormone ◽  
Ovarian Failure ◽  
Nerve Growth ◽  
Stimulating Hormone

Chemotherapy leads to a loss of fertility and reproductive endocrine function, thereby increasing the risk of premature ovarian failure (POF). Studies have suggested that the transplantation of mesenchymal stem cells could inhibit apoptosis in ovarian granulosa cells and improve follicular development. In the present study, the effects of human umbilical cord mesenchymal stem cell (UCMSC) transplantation on ovarian function after ovarian damage caused by chemotherapy and the mechanism underlying these effects were investigated. POF model rats were obtained by the intraperitoneal injection of cyclophosphamide, and cultured UCMSCs were transplanted by tail vein injection. Serum estrogen, follicle-stimulating hormone, gonadotropin releasing hormone, and anti-Mullerian hormone levels were detected by ELISA. Folliculogenesis was evaluated by histopathological examination. The expression levels of nerve growth factor (NGF), high affinity nerve growth factor receptor (TrkA), follicle-stimulating hormone receptor (FSHR), and caspase-3 were evaluated by western blotting and RT-qPCR. The natural reproductive capacity was assessed by pregnant rate and numbers of embryos. The results indicated that UCMSC transplantation recovered disturbed hormone secretion and folliculogenesis in POF rats. NGF and TrkA levels increased, while FSHR and caspase-3 decreased. The pregnancy rate of POF rats was improved. Therefore, UCMSCs could reduce ovarian failure due to premature senescence caused by chemotherapy, and the NGF/TrkA signaling pathway was involved in the amelioration of POF.

scholarly journals Small Peptide Mimics of Nerve Growth Factor Bind TrkA Receptors and Affect Biological Responses

1995 ◽  
Vol 270 (12) ◽  
pp. 6564-6569 ◽  
Author(s):  
Lynne LeSauteur ◽  
Ling Wei ◽  
Bernard F. Gibbs ◽  
H. Uri Saragovi
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Small Peptide ◽  
Peptide Mimics ◽  
Nerve Growth ◽  
Biological Responses ◽  
Trka Receptors

A Quantitative Bioassay for Nerve Growth Factor,Using PC12 Clones Expressing Different Levels of trkA Receptors

2002 ◽  
Vol 18 (3) ◽  
pp. 251-264 ◽  
Author(s):  
Itzhak Katzir ◽  
Jashovam Shani ◽  
Keren Regev ◽  
Dalia Shabashov ◽  
Philip Lazarovici
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Trka Receptors ◽  
Different Levels ◽  
Quantitative Bioassay
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