scholarly journals Authors’ Response: FSH Receptor Polymorphism and Iatrogenic Ovarian Hyperstimulation

2005 ◽  
Vol 90 (8) ◽  
pp. 4978-4979
Author(s):  
Caroline Daelemans ◽  
Guillaume Smits ◽  
Viviane De Maertelaer ◽  
Sabine Costagliola ◽  
Yvon Englert ◽  
...  
Keyword(s):  
Fsh Receptor ◽  
Ovarian Hyperstimulation ◽  
Fsh Receptor Polymorphism ◽  
Receptor Polymorphism

scholarly journals The impact of FSH receptor polymorphism on time-to-pregnancy: a cross-sectional single-centre study

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Birute Zilaitiene ◽  
Marius Dirzauskas ◽  
Rasa Verkauskiene ◽  
Rytas Ostrauskas ◽  
Joerg Gromoll ◽  
...  
Keyword(s):  
Fsh Receptor ◽  
Single Centre ◽  
Time To Pregnancy ◽  
Cross Sectional ◽  
Centre Study ◽  
Single Centre Study ◽  
The Impact ◽  
Fsh Receptor Polymorphism ◽  
Receptor Polymorphism

scholarly journals Poor ovarian response to gonadotrophin stimulation is associated with FSH receptor polymorphism

2009 ◽  
Vol 18 (4) ◽  
pp. 509-515 ◽  
Author(s):  
Swati K Achrekar ◽  
Deepak N Modi ◽  
Sadhana K Desai ◽  
Vijay S Mangoli ◽  
Ranjana V Mangoli ◽  
...  
Keyword(s):  
Ovarian Response ◽  
Fsh Receptor ◽  
Poor Ovarian Response ◽  
Fsh Receptor Polymorphism ◽  
Receptor Polymorphism

FSH receptor polymorphism predicts outcome of ovulation induction in WHO-II anovulatory subfertility

2011 ◽  
Vol 96 (3) ◽  
pp. S34-S35
Author(s):  
O. Valkenburg ◽  
N.B. Lambalk ◽  
E.J.P. van Santbrink ◽  
A.G. Uitterlinden ◽  
B.C.J.M. Fauser ◽  
...  
Keyword(s):  
Ovulation Induction ◽  
Fsh Receptor ◽  
Fsh Receptor Polymorphism ◽  
Receptor Polymorphism

scholarly journals Specificity and promiscuity of gonadotropin receptors

Reproduction ◽  
2005 ◽  
Vol 130 (3) ◽  
pp. 275-281 ◽  
Author(s):  
Sabine Costagliola ◽  
Eneko Urizar ◽  
Fernando Mendive ◽  
Gilbert Vassart
Keyword(s):  
Hormone Receptors ◽  
Fsh Receptor ◽  
Ovarian Hyperstimulation ◽  
High Concentration ◽  
Glycoprotein Hormone ◽  
Functional Specificity ◽  
The Past ◽  
Glycoprotein Hormone Receptors ◽  
Naturally Occurring ◽  
Available Information

The dichotomy between hormone recognition by the ectodomain and activation of the G protein by the rhodopsin-like serpentine portion is a well established property of glycoprotein hormone receptors. The specificity barrier avoiding promiscuous activation of the FSH receptor by the high concentration of human chorionic gonadotropin (hCG) prevailing during human pregnancy was thus believed to lie in the ectodomain. In the past two years, mutations responsible for rare spontaneous cases of ovarian hyperstimulation syndromes have partially modified this simple view. Five naturally occurring mutations have been identified which cause an increase in the sensitivity of the FSH receptor to hCG. Surprisingly, these mutations are all located in the serpentine portion of the receptor. In addition to their effect on sensitivity to hCG, they increase sensitivity of the FSH receptor to TSH, and are responsible for activating the receptor constitutively. Together, the available information indicates that the ectodomain and the serpentine domain of the FSH receptor each contribute to the specificity barrier preventing its spurious activation by hCG. While the former is responsible for establishment of binding specificity, the latter introduces a novel notion of functional specificity.Recent data demonstrate that LH and FSH receptors can constitute functional homo- and heterodimers. This suggests the possibility that in cells co-expressing the two receptors, such as granulosa cells, the heterodimers might be endowed with functional characteristics different from those of each homodimer.

scholarly journals Spontaneous Ovarian Hyperstimulation Syndrome with FSH Receptor Gene Mutation: Two Rare Case Reports

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Emsal Pinar Topdagi Yilmaz ◽  
Omer Erkan Yapca ◽  
Yunus Emre Topdagi ◽  
Seray Kaya Topdagi ◽  
Yakup Kumtepe
Keyword(s):  
Gene Mutation ◽  
Ovarian Hyperstimulation Syndrome ◽  
Case Reports ◽  
Receptor Gene ◽  
First Trimester ◽  
Fsh Receptor ◽  
Ovarian Hyperstimulation ◽  
Ovulatory Cycle ◽  
Fshr Gene ◽  
Stimulating Hormone

Development of ovarian hyperstimulation syndrome (OHSS) is very rare in a spontaneous ovulatory cycle and it is usually seen during pregnancy. In the etiology of OHSS, higher hCG (molar pregnancies or multiple pregnancies) and thyroid-stimulating hormone (TSH) levels have been accused. In recent years, some follicle-stimulating hormone (FSH) receptor (FSHR) gene mutations have been described in patients with OHSS in the first trimester with normal hCG levels. Herein, we report two cases of FSHR gene mutation during the investigation of the etiology of spontaneous OHSS. Although OHSS is typically associated with ovulation induction, it should be kept in mind that this condition may also develop in spontaneous pregnancies.

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