scholarly journals Obese Subjects Carrying the 11482G>A Polymorphism at the Perilipin Locus Are Resistant to Weight Loss after Dietary Energy Restriction

2005 ◽  
Vol 90 (9) ◽  
pp. 5121-5126 ◽  
Author(s):  
Dolores Corella ◽  
Lu Qi ◽  
José V. Sorlí ◽  
Diego Godoy ◽  
Olga Portolés ◽  
...  
Keyword(s):  
Weight Loss ◽  
Energy Restriction ◽  
Dietary Energy ◽  
Dietary Energy Restriction ◽  
Obese Subjects

scholarly journals Dietary Energy Restriction and Successful Weight Loss in Obese Client-Owned Dogs

2007 ◽  
Vol 21 (6) ◽  
pp. 1174-1180 ◽  
Author(s):  
Alexander J. German ◽  
Shelley L. Holden ◽  
Thomas Bissot ◽  
Rachel M. Hackett ◽  
Vincent Biourge
Keyword(s):  
Weight Loss ◽  
Energy Restriction ◽  
Dietary Energy ◽  
Dietary Energy Restriction ◽  
Successful Weight Loss

scholarly journals Low or Moderate Dietary Energy Restriction for Long-term Weight Loss: What Works Best?

Obesity ◽  
2009 ◽  
Vol 17 (11) ◽  
pp. 2019-2024 ◽  
Author(s):  
Sai Krupa Das ◽  
Edward Saltzman ◽  
Cheryl H. Gilhooly ◽  
James P. DeLany ◽  
Julie K. Golden ◽  
...  
Keyword(s):  
Weight Loss ◽  
Energy Restriction ◽  
Dietary Energy ◽  
What Works ◽  
Dietary Energy Restriction

scholarly journals Real World Adherence to a Severely Energy Restricted Meal Replacement Diet in Participants with Class II and III Obesity

Obesities ◽  
2022 ◽  
Vol 2 (1) ◽  
pp. 8-20
Author(s):  
Gabrielle Maston ◽  
Hamid Reza Kahlaee ◽  
Janet Franklin ◽  
Elisia Manson ◽  
Alice A. Gibson ◽  
...  
Keyword(s):  
Weight Loss ◽  
Energy Intake ◽  
Repeated Measures ◽  
Class Ii ◽  
Energy Restriction ◽  
Dietary Energy ◽  
Weight Changes ◽  
Meal Replacement ◽  
Entire Cohort ◽  
Dietary Energy Restriction

Severely energy-restricted diets (SERDs) are an effective treatment for obesity, however, adherence to such diets is often perceived as poor by healthcare professionals. This investigation evaluated adherence to a 12-week SERD in participants with class II and III obesity. Reported food consumption was compared against individualised SERD prescriptions. Body weight measures were obtained at baseline, 12 and 52 weeks. The data were analysed in three groups (i) the entire cohort (n = 26), (ii) completers (n = 13) and (iii) non-completers (n = 13). SERD prescription elements included (i) the number of meal replacement products; (ii) total protein; (iii) total energy intake; (iv) level of dietary energy restriction; (v) vegetable serves; (vi) water serves, and (vii) how much physical activity was performed. A generalised repeated-measures mixed-effects model was used to investigate if adherence to the program elements individually, or collectively, influenced weight loss. Completers had an average (± SD) of 4549 ± 748 kJ energy intake per day, resulting in a mean energy restriction of 62% compared to the 69% prescribed, indicating a degree of non-adherence. The percent weight changes for completers and non-completers were −7.8 ± 4.7% and −1.6 ± 2.6% at 12 weeks, and −12.2 ± 12.1% and −1.8 ± 3.2% at 52 weeks, respectively. Complete dietary adherence to a SERD may not be necessary to achieve a clinically relevant weight loss of 12% at 52 weeks, if energy is restricted by at least 62% (~4600 kJ per day) relative to requirements.

scholarly journals Carbohydrate Restriction, Dietary Energy Restriction and Weight Loss in Obese Mice: Metabolic Insights

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Elizabeth Ann Williams ◽  
Susan N Perkins ◽  
Nicole CP Smith ◽  
Stephen D Hursting ◽  
Michelle A Lane
Keyword(s):  
Weight Loss ◽  
Energy Restriction ◽  
Dietary Energy ◽  
Carbohydrate Restriction ◽  
Obese Mice ◽  
Dietary Energy Restriction

scholarly journals Cardiometabolic and reproductive benefits of early dietary energy restriction and voluntary exercise in an obese PCOS-prone rodent model

2015 ◽  
Vol 226 (3) ◽  
pp. 193-206 ◽  
Author(s):  
Abdoulaye Diane ◽  
Maria Kupreeva ◽  
Faye Borthwick ◽  
Spencer D Proctor ◽  
W David Pierce ◽  
...  
Keyword(s):  
Cardiometabolic Risk ◽  
Energy Restriction ◽  
Rodent Model ◽  
Voluntary Exercise ◽  
Chow Diet ◽  
Adult Women ◽  
Dietary Energy ◽  
Lean Control ◽  
Dietary Energy Restriction ◽  
Reproductive Indices

Polycystic ovary syndrome (PCOS) is one of the most common endocrine-metabolic disorders in women of reproductive age characterized by ovulatory dysfunction, hyperandrogenism and cardiometabolic risk. The overweight-obese PCOS phenotype appears to have exacerbated reproductive dysfunction and cardiometabolic risk. In overweight-obese adult women with PCOS, exercise and energy restricted diets have shown limited and inconsistent effects on both cardiometabolic indices and reproductive outcomes. We hypothesized that an early lifestyle intervention involving exercise and dietary energy restriction to prevent or reduce the propensity for adiposity would modulate reproductive indices and cardiometabolic risk in an obese PCOS-prone rodent model. Weanling obese PCOS-prone and Lean-Control JCR:LA-cp rodents were given a chow dietad libitumor an energy-restricted diet combined with or without voluntary exercise (4 h/day) for 8 weeks. Dietary energy restriction and exercise lowered total body weight gain and body fat mass by 30% compared to free-fed sedentary or exercising obese PCOS-prone animals (P<0.01). Energy restriction induced an increase in exercise intensity compared to free-feeding plus exercise conditions. Energy restriction and exercise decreased fasting plasma triglycerides and apoB48 concentrations in obese PCOS-prone animals compared to free-fed and exercise or sedentary groups. The energy restriction and exercise combination in obese PCOS-prone animals significantly increased plasma sex-hormone binding globulin, hypothalamic cocaine-and amphetamine-regulated transcript (CART) and Kisspeptin mRNA expression to levels of the Lean-Control group, and this was further associated with improvements in estrous cyclicity. The combination of exercise and dietary energy restriction when initiated in early life exerts beneficial effects on cardiometabolic and reproductive indices in an obese PCOS-prone rodent model, and this may be associated with normalization of the hypothalamic neuropeptides, Kisspeptin and CART.

scholarly journals Does severe dietary energy restriction increase binge eating in overweight or obese individuals? A systematic review

2015 ◽  
Vol 16 (8) ◽  
pp. 652-665 ◽  
Author(s):  
F. Q. da Luz ◽  
P. Hay ◽  
A. A. Gibson ◽  
S. W. Touyz ◽  
J. M. Swinbourne ◽  
...  
Keyword(s):  
Systematic Review ◽  
Binge Eating ◽  
Energy Restriction ◽  
Dietary Energy ◽  
Dietary Energy Restriction

scholarly journals SGCG rs679482 Associates with Weight Loss Success in Response to an Intensively Supervised Outpatient Program

2020 ◽  
Author(s):  
Ada Admin ◽  
Majid Nikpay ◽  
Paulina Lau ◽  
Sébastien Soubeyrand ◽  
Katey L Whytock ◽  
...  
Keyword(s):  
Weight Loss ◽  
Meta Analysis ◽  
Energy Restriction ◽  
European Ancestry ◽  
Open Chromatin ◽  
Enhancer Activity ◽  
Heritable Trait ◽  
Novel Variant ◽  
Preferential Binding ◽  
Obese Subjects

Weight loss in response to energy restriction is highly variable and identification of genetic contributors can provide insights into underlying biology. Leveraging 1000 Genomes imputed genotypes we carried out GWAS analysis in 551 unrelated obese subjects of European ancestry who participated in an intensively supervised weight loss program with replication of promising signals in an independent sample of 1,331 obese subjects who completed the program at a later date.<b> </b>By SNP-based and sib-pair analysis, we show that that weight loss is a heritable trait with estimated heritability (<i>h</i><sup>2</sup>=0.49) within the range reported for obesity. We find rs679482, intronic to <i>SGCG</i> (sarcoglycan gamma), highly expressed in skeletal muscle, to concordantly associate with weight loss in discovery and replication samples reaching GWAS significance in the combined meta-analysis (ß=-0.35, P=1.7×10<sup>-12</sup>). Located in a region of open chromatin, rs679482 is predicted to bind DMRT2 and allele-specific transcription factor binding analysis indicates preferential binding of DMRT2 to rs679482-A. Concordantly, rs679482-A impairs native repressor activity and increases basal and DMRT2 mediated enhancer activity. These findings confirm that weight loss is a heritable trait and provide evidence by which a novel variant in SGCG, rs679482 leads to impaired diet response.

scholarly journals Dietary Energy Restriction Ameliorates Cognitive Impairment in a Mouse Model of Traumatic Brain Injury

2019 ◽  
Vol 67 (4) ◽  
pp. 613-621 ◽  
Author(s):  
V. Rubovitch ◽  
A. Pharayra ◽  
M. Har-Even ◽  
O. Dvir ◽  
M. P. Mattson ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Cognitive Impairment ◽  
Brain Injury ◽  
Mouse Model ◽  
Energy Restriction ◽  
Dietary Energy ◽  
Dietary Energy Restriction
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