scholarly journals Regulation of Neuroendocrine Differentiation in Gastrointestinal Carcinoid Tumor Cells by Notch Signaling

2005 ◽  
Vol 90 (7) ◽  
pp. 4350-4356 ◽  
Author(s):  
Eric K. Nakakura ◽  
Virote R. Sriuranpong ◽  
Muthusamy Kunnimalaiyaan ◽  
Edward C. Hsiao ◽  
Kornel E. Schuebel ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Tumor Cells ◽  
Carcinoid Tumor ◽  
Neuroendocrine Differentiation ◽  
Gastrointestinal Carcinoid

Thiocoraline activates transcription of notch and inhibits the proliferation of carcinoid tumor cells

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
TP Wyche ◽  
R Jaskula-Sztul ◽  
A Dammalapati ◽  
H Cho ◽  
G Kwon ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Carcinoid Tumor

scholarly journals Fibrolamellar Carcinoma: 2012 Update

Scientifica ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Michael Torbenson
Keyword(s):  
Tumor Cells ◽  
Primary Liver Cancer ◽  
Neuroendocrine Differentiation ◽  
Science Literature ◽  
Unique Type ◽  
Younger Age ◽  
Genetic Abnormalities ◽  
Fibrolamellar Carcinoma ◽  
Prognostic Feature ◽  
Children And Young Adults

Fibrolamellar carcinomas are a unique type of primary liver cancer. They occur most commonly in children and young adults. Their etiology remains a mystery, as they are not associated with chronic liver disease. Fibrolamellar carcinomas are not indolent tumors, but have an overall better prognosis than typical hepatocellular carcinomas, in part because of the younger age at presentation and the lack of cirrhosis. The most important prognostic feature is whether the tumor is resectable. Histologically, the tumor is made up of large cells that contain abundant mitochondria. The nuclei of the tumor cells have prominent nucleoli. The tumor cells induce the formation of extensive intratumoral fibrosis, which often grows in parallel, or lamellar bands. The tumor cells clearly show hepatocellular features but are also unique in showing both biliary and neuroendocrine differentiation. The uniqueness of fibrolamellar carcinoma extends to their molecular findings. While the genetic abnormalities that lead to fibrolamellar carcinomas are not yet known, studies have shown that they lack mutations in the genes most commonly mutated in typical hepatocellular carcinoma (TP53andCTNNB1). In this paper, the clinical, pathological, and basic science literature on fibrolamellar carcinoma is comprehensively reviewed. Key areas of needed research are also discussed.

Thiocoraline Regulates Neuroendocrine Phenotype and Inhibits Proliferation in Carcinoid Tumor Cells

2012 ◽  
Vol 172 (2) ◽  
pp. 237 ◽  
Author(s):  
J.A. Sohn ◽  
B. Zarebczan ◽  
T.P. Wyche ◽  
T.S. Bugni ◽  
M. Kunnimalaiyaan ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Carcinoid Tumor

Adrenergic control of serotonin release from carcinoid tumor cells in vitro and in vivo

1987 ◽  
Vol 42 (2) ◽  
pp. 141-146 ◽  
Author(s):  
K.O. Grönstad ◽  
O. Nilsson ◽  
A. Dahlström ◽  
G. Skolnik ◽  
H. Ahlman
Keyword(s):  
Tumor Cells ◽  
Carcinoid Tumor ◽  
Serotonin Release ◽  
Adrenergic Control

scholarly journals The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis

2019 ◽  
Vol 33 (23-24) ◽  
pp. 1718-1738 ◽  
Author(s):  
Matthew G. Oser ◽  
Amin H. Sabet ◽  
Wenhua Gao ◽  
Abhishek A. Chakraborty ◽  
Anna C. Schinzel ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Notch Signaling ◽  
Cell Lung Cancer ◽  
Neuroendocrine Differentiation ◽  
Small Cell ◽  
Histone Demethylase ◽  
Small Cell Lung
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