scholarly journals Polymorphisms in the Estrogen Receptor β (ESR2) Gene Are Associated with Bone Mineral Density in Caucasian Men and Women

2005 ◽  
Vol 90 (11) ◽  
pp. 5921-5927 ◽  
Author(s):  
Shoji Ichikawa ◽  
Daniel L. Koller ◽  
Munro Peacock ◽  
Michelle L. Johnson ◽  
Dongbing Lai ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Estrogen Receptor ◽  
Bone Mineral ◽  
Estrogen Receptor Β ◽  
Mineral Density ◽  
Men And Women ◽  
Caucasian Men ◽  
Esr2 Gene

Bone Mineral Density in Caucasian Men and Women Ages 35 to 50

2010 ◽  
Vol 42 ◽  
pp. 703
Author(s):  
Martha Bass ◽  
Allison Ford-Wade ◽  
Andy Mauromoustakos
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Men And Women ◽  
Caucasian Men

Association of Estrogen Receptor β Gene Polymorphism with Bone Mineral Density

2000 ◽  
Vol 269 (2) ◽  
pp. 537-541 ◽  
Author(s):  
Sumito Ogawa ◽  
Takayuki Hosoi ◽  
Masataka Shiraki ◽  
Hajime Orimo ◽  
Mitsuru Emi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Estrogen Receptor ◽  
Gene Polymorphism ◽  
Bone Mineral ◽  
Estrogen Receptor Β ◽  
Mineral Density

Impaired Estrogen Sensitivity in Bone by Inhibiting Both Estrogen Receptor a and b Pathways*

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Bone Mineral Density ◽  
Estrogen Receptor ◽  
Bone Loss ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Female Rats ◽  
Wild Type ◽  
Mineral Density ◽  
Transgenic Rats ◽  
Estrogen Sensitivity

Although it is well established that estrogen deficiencycauses osteoporosis among the postmenopausalwomen, the involvement of estrogen receptor (ER) in itspathogenesis still remains uncertain. In the presentstudy, we have generated rats harboring a dominantnegative ERa, which inhibits the actions of not only ERabut also recently identified ERb. Contrary to our expectation,the bone mineral density (BMD) of the resultingtransgenic female rats was maintained at the same levelwith that of the wild-type littermates when sham-operated.In addition, ovariectomy-induced bone loss wasobserved almost equally in both groups. Strikingly, however,the BMD of the transgenic female rats, after ovariectomized,remained decreased even if 17b-estradiol(E2) was administrated, whereas, in contrast, the decreaseof littermate BMD was completely prevented byE2. Moreover, bone histomorphometrical analysis ofovariectomized transgenic rats revealed that the higherrates of bone turnover still remained after treatmentwith E2. These results demonstrate that the preventionfrom the ovariectomy-induced bone loss by estrogen ismediated by ER pathways and that the maintenanceof BMD before ovariectomy might be compensatedby other mechanisms distinct from ERa and ERbpathways.

scholarly journals The Association of Lumbar Disc Herniation with Lumbar Volumetric Bone Mineral Density in a Cross-Sectional Chinese Study

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 938
Author(s):  
Jian Geng ◽  
Ling Wang ◽  
Qing Li ◽  
Pengju Huang ◽  
Yandong Liu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Lumbar Disc ◽  
Magnetic Resonance Images ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density ◽  
Men And Women ◽  
The Relationship

Little is known about the effect of lumbar intervertebral disc herniation (LDH) on lumbar bone mineral density (BMD), and few previous studies have used quantitative computed tomography (QCT) to assess whether the staging of LDH correlates with lumbar vertebral trabecular volumetric bone mineral density (Trab.vBMD). To explore the relationship between lumbar Trab.vBMD and LDH, seven hundred and fifty-four healthy participants aged 20–60 years were enrolled in the study from an ongoing study on the degeneration of the spine and knee between June 2014 and 2017. QCT was used to measure L2–4 Trab.vBMD and lumbar spine magnetic resonance images (MRI) were performed to assess the incidence of disc herniation. After 9 exclusions, a total of 322 men and 423 women remained. The men and women were divided into younger (age 20–39 years) and older (age 40–60 years) groups and further into those without LDH, with a single LDH segment, and with ≥2 segments. Covariance analysis was used to adjust for the effects of age, BMI, waistline, and hipline on the relationship between Trab.vBMD and LDH. Forty-one younger men (25.0%) and 59 older men (37.3%) had at least one LDH segment. Amongst the women, the numbers were 46 (22.5%) and 80 (36.4%), respectively. Although there were differences in the characteristics data between men and women, the difference in Trab.vBMD between those without LDH and those with single and ≥2 segments was not statistically significant (p > 0.05). These results remained not statistically significant after further adjusting for covariates (p > 0.05). No associations between lumbar disc herniation and vertebral trabecular volumetric bone mineral density were observed in either men or women.

scholarly journals Determinants of Bone Mineral Density in Older Men and Women: Body Composition as Mediator

2001 ◽  
Vol 16 (11) ◽  
pp. 2142-2151 ◽  
Author(s):  
S. M. F. Pluijm ◽  
M. Visser ◽  
J. H. Smit ◽  
C. Popp-Snijders ◽  
J. C. Roos ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Bone Mineral ◽  
Older Men ◽  
Mineral Density ◽  
Men And Women ◽  
Older Men And Women

Muscle mass and fat mass in relation to bone mineral density in very old men and women: the Framingham Heart Study

1998 ◽  
Vol 49 (5-6) ◽  
pp. 745-747 ◽  
Author(s):  
M. Visser ◽  
D.P. Kiel ◽  
J. Langlois ◽  
M.T. Hannan ◽  
D.T. Felson ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Muscle Mass ◽  
Bone Mineral ◽  
Fat Mass ◽  
Framingham Heart Study ◽  
Mineral Density ◽  
Men And Women ◽  
Very Old ◽  
Heart Study ◽  
Old Men
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