scholarly journals Endothelial Dysfunction in Young Women with Polycystic Ovary Syndrome: Relationship with Insulin Resistance and Low-Grade Chronic Inflammation

2004 ◽  
Vol 89 (11) ◽  
pp. 5592-5596 ◽  
Author(s):  
İlhan Tarkun ◽  
Berrı̇n Ç. Arslan ◽  
Zeynep Cantürk ◽  
Erdem Türemen ◽  
Tayfun Şahı̇n ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Endothelial Dysfunction ◽  
Polycystic Ovary Syndrome ◽  
Chronic Inflammation ◽  
Young Women ◽  
Polycystic Ovary ◽  
Low Grade ◽  
Ovary Syndrome

scholarly journals Hyperandrogenism and Insulin Resistance, Not Changes in Body Weight, Mediate the Development of Endothelial Dysfunction in a Female Rat Model of Polycystic Ovary Syndrome (PCOS)

Endocrinology ◽  
2015 ◽  
Vol 156 (11) ◽  
pp. 4071-4080 ◽  
Author(s):  
Amanda Hurliman ◽  
Jennifer Keller Brown ◽  
Nicole Maille ◽  
Maurizio Mandala ◽  
Peter Casson ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Weight Gain ◽  
Insulin Sensitivity ◽  
Endothelial Dysfunction ◽  
Polycystic Ovary Syndrome ◽  
Rat Model ◽  
Polycystic Ovary ◽  
Phase 1 ◽  
Ovary Syndrome

This study was designed to differentiate the contributions of hyperandrogenism, insulin resistance (IR), and body weight to the development of endothelial dysfunction in polycystic ovary syndrome and determine the effectiveness of insulin sensitization and antiandrogenic therapy after the establishment of vascular and metabolic dysfunction using a rat model of polycystic ovary syndrome. We hypothesized that the observed endothelial dysfunction was a direct steroidal effect, as opposed to changes in insulin sensitivity or body weight. Prepubertal female rats were randomized to the implantation of a pellet containing DHT or sham procedure. In phase 1, DHT-exposed animals were randomized to pair feeding to prevent weight gain or metformin, an insulin-sensitizing agent, from 5 to 14 weeks. In phase 2, DHT-exposed animals were randomized to treatment with metformin or flutamide, a nonsteroidal androgen receptor blocker from 12 to 16 weeks. Endothelial function was assessed by the vasodilatory response of preconstricted arteries to acetylcholine. Serum steroid levels were analyzed in phase 1 animals. Fasting blood glucose and plasma insulin were analyzed and homeostasis model assessment index calculated in all animals. Our data confirm the presence of endothelial dysfunction as well as increased body weight, hypertension, hyperinsulinemia, and greater IR among DHT-treated animals. Even when normal weight was maintained through pair feeding, endothelial dysfunction, hyperinsulinemia, and IR still developed. Furthermore, despite weight gain, treatment with metformin and flutamide improved insulin sensitivity and blood pressure and restored normal endothelial function. Therefore, the observed endothelial dysfunction is most likely a direct result of hyperandrogenism-induced reductions in insulin sensitivity, as opposed to weight gain.

Obesity and insulin resistance increase plasma viscosity in young women with polycystic ovary syndrome

2009 ◽  
Vol 25 (10) ◽  
pp. 640-646 ◽  
Author(s):  
Vasiliki Vervita ◽  
Alexandros D. Saltamavros ◽  
George Adonakis ◽  
Vasilios Tsapanos ◽  
George Decavalas ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Polycystic Ovary ◽  
Plasma Viscosity ◽  
Ovary Syndrome ◽  
Resistance Increase

Insulin resistance causes impaired vasodilation and hypofibrinolysis in young women with polycystic ovary syndrome

2005 ◽  
Vol 116 (3) ◽  
pp. 207-214 ◽  
Author(s):  
Franco Carmassi ◽  
Ferdinando De Negri ◽  
Roberta Fioriti ◽  
Antonio De Giorgi ◽  
Chiara Giannarelli ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Polycystic Ovary ◽  
Ovary Syndrome

Predictors of Endothelial Dysfunction in Young Women With Polycystic Ovary Syndrome

2006 ◽  
Vol 61 (4) ◽  
pp. 245-246
Author(s):  
Maria Kravariti ◽  
Katerina K. Naka ◽  
Sophia N. Kalantaridou ◽  
Nikolaos Kazakos ◽  
Christos S. Katsouras ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Regional Brain Glucose Hypometabolism in Young Women with Polycystic Ovary Syndrome: Possible Link to Mild Insulin Resistance

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0144116 ◽  
Author(s):  
Christian-Alexandre Castellano ◽  
Jean-Patrice Baillargeon ◽  
Scott Nugent ◽  
Sébastien Tremblay ◽  
Mélanie Fortier ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Brain Glucose ◽  
Regional Brain ◽  
Glucose Hypometabolism
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