scholarly journals Plasma Acylation-Stimulating Protein, Adiponectin, Leptin, and Ghrelin before and after Weight Loss Induced by Gastric Bypass Surgery in Morbidly Obese Subjects

2003 ◽  
Vol 88 (4) ◽  
pp. 1594-1602 ◽  
Author(s):  
May Faraj ◽  
Peter J. Havel ◽  
Steve Phélis ◽  
David Blank ◽  
Allan D. Sniderman ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Morbidly Obese ◽  
Acylation Stimulating Protein ◽  
Before And After ◽  
Obese Subjects

Circulating Peptide YY, Weight Loss, and Glucose Homeostasis After Gastric Bypass Surgery in Morbidly Obese Subjects

2008 ◽  
Vol 247 (2) ◽  
pp. 270-275 ◽  
Author(s):  
Rosa Morínigo ◽  
Josep Vidal ◽  
Antonio M. Lacy ◽  
Salvadora Delgado ◽  
Roser Casamitjana ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Glucose Homeostasis ◽  
Bypass Surgery ◽  
Peptide Yy ◽  
Gastric Bypass Surgery ◽  
Morbidly Obese ◽  
Obese Subjects

Long-Term Effects of Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Surgery on Type 2 Diabetes Mellitus in Morbidly Obese Subjects

2012 ◽  
Vol 256 (6) ◽  
pp. 1023-1029 ◽  
Author(s):  
Amanda Jiménez ◽  
Roser Casamitjana ◽  
Lílliam Flores ◽  
Judith Viaplana ◽  
Ricard Corcelles ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Morbidly Obese ◽  
Long Term Effects ◽  
Obese Subjects

Effect of weight loss on muscle lipid content in morbidly obese subjects

2003 ◽  
Vol 284 (4) ◽  
pp. E726-E732 ◽  
Author(s):  
Robert E. Gray ◽  
Charles J. Tanner ◽  
Walter J. Pories ◽  
Kenneth G. MacDonald ◽  
Joseph A. Houmard
Keyword(s):  
Weight Loss ◽  
Insulin Action ◽  
Fiber Type ◽  
Gastric Bypass Surgery ◽  
Morbidly Obese ◽  
Type I ◽  
Fiber Types ◽  
Model Assessment ◽  
Before And After ◽  
Obese Subjects

The purpose of this study was to test the hypothesis that weight loss results in a reduction in intramuscular lipid (IMCL) content that is concomitant with enhanced insulin action. Muscle biopsies were obtained from morbidly obese individuals [body mass index (BMI) 52.2 ± 2.5 kg/m2; n= 6] before and after gastric bypass surgery, an intervention that improves insulin action. With intervention, there was a 47% reduction ( P < 0.01) in BMI and a 93% decrease in homeostasis model assessment, or HOMA (7.0 ± 1.9 vs. 0.5 ± 0.1). Histochemically determined IMCL content decreased ( P < 0.05) by ∼30%. In relation to fiber type, IMCL was significantly higher in type I vs. type II fibers. In both fiber types, there were reductions in IMCL and trends for muscle atrophy. Despite these two negating factors, the IMCL-to-fiber area ratio still decreased by ∼44% with weight loss. In conclusion, despite differing initial levels and possible atrophy, weight loss appears to decrease IMCL deposition to a similar relative extent in type I and II muscle fibers. This reduction in intramuscular triglyceride may contribute to enhanced insulin action seen with weight loss.

scholarly journals Association of Circulating Irisin Concentrations with Weight Loss after Roux-en-Y Gastric Bypass Surgery

2019 ◽  
Vol 16 (4) ◽  
pp. 660 ◽  
Author(s):  
Yeon Lee ◽  
Yoonseok Heo ◽  
Ji-Ho Choi ◽  
Sunghyouk Park ◽  
Kyoung Kim ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Excess Weight Loss ◽  
Gastric Bypass Surgery ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Preoperative Serum ◽  
One Year

Irisin is a myokine with potential anti-obesity properties that has been suggested to increase energy expenditure in obese patients. However, there is limited clinical information on the biology of irisin in humans, especially in morbidly obese patients undergoing bariatric surgery. We aimed to assess the association of circulating irisin concentrations with weight loss in obese patients undergoing bariatric surgery. This was a pilot, single-centre, longitudinal observational study. We recruited 25 morbidly obese subjects who underwent Roux-en-Y gastric bypass surgery (RYGBP), and blood samples from 12 patients were taken to measure serum irisin concentrations before, and one and nine months after surgery. Their clinical characteristics were measured for one year. The preoperative serum irisin concentration (mean 1.01 ± 0.23 μg/mL, range 0.73–1.49) changed bidirectionally one month after RYGBP. The mean concentration at nine months was 1.11 ± 0.15 μg/mL (range 0.92–1.35). Eight patients had elevated irisin levels compared with their preoperative values, but four did not. Elevations of irisin levels nine months, but not one month, after surgery, were associated with lower preoperative levels (p = 0.016) and worse weight reduction rates (p = 0.006 for the percentage excess weight loss and p = 0.032 for changes in body mass index). The preoperative serum irisin concentrations were significantly correlated with the percentage of excess weight loss for one year (R2 = 0.612; p = 0.04) in our study. Our results suggest that preoperative circulating irisin concentrations may be at least in part associated with a weight loss effect of bariatric surgery in morbidly obese patients. Further large-scale clinical studies are needed to ratify these findings.

Ghrelin and Obestatin Levels in Severely Obese Women Before and After Weight Loss After Roux-en-Y Gastric Bypass Surgery

2008 ◽  
Vol 19 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Christian L. Roth ◽  
Thomas Reinehr ◽  
Gerit-Holger Schernthaner ◽  
Hans-Peter Kopp ◽  
Stefan Kriwanek ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Obese Women ◽  
Before And After ◽  
Severely Obese

scholarly journals Striatal dopamine receptor binding in morbidly obese women before and after gastric bypass surgery and its relationship with insulin sensitivity

Diabetologia ◽  
2014 ◽  
Vol 57 (5) ◽  
pp. 1078-1080 ◽  
Author(s):  
Barbara A. de Weijer ◽  
Elsmarieke van de Giessen ◽  
Ignace Janssen ◽  
Frits J. Berends ◽  
Arnold van de Laar ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Insulin Sensitivity ◽  
Receptor Binding ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Morbidly Obese ◽  
Obese Women ◽  
Before And After ◽  
Striatal Dopamine Receptor ◽  
Dopamine Receptor Binding

PEAK METABOLIC RESPONSES OF THE MORBIDLY OBESE BEFORE AND AFTER GASTRIC BYPASS SURGERY

1986 ◽  
Vol 18 (supplement) ◽  
pp. S89
Author(s):  
R. G. Israel ◽  
W. J. Poriea ◽  
M. L. Delozier ◽  
M. R. McCammon ◽  
P. L. Eubanka ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Metabolic Responses ◽  
Morbidly Obese ◽  
Before And After

Body Composition and Aerobic Capacity in Morbidly Obese Females

1986 ◽  
Vol 3 (3) ◽  
pp. 259-267 ◽  
Author(s):  
Mollie G. DeLozier ◽  
Richard G. Israel ◽  
Kevin F. O’Brien ◽  
Robert A. Shaw ◽  
Walter J. Pories
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Body Composition ◽  
Aerobic Capacity ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Relative Weight ◽  
Morbidly Obese ◽  
Large Weight ◽  
Large Weight Loss

This investigation quantified body composition and aerobic capacity and examined the interrelationships of these measures in 20 morbidly obese females (M age = 34.6 yrs) prior to gastric bypass surgery. Fifteen subjects were hydrostatically weighed at residual lung volume in order to determine body composition. Eighteen subjects performed a maximal modified progressive treadmill test to determine aerobic capacity. Results indicated that the 15 subjects who were weighed hydrostatically were heavier (M wt = 132.34 kg) and fatter (M % fat = 53.18) than any previously described individuals. Relative weight, which is used as a criterion to determine surgery eligibility, was not significantly (p > .05) correlated to percent body fat. Mean aerobic capacity (V̇O2 = 14.99 ml • kg-1 mir-1) was comparable to Class III cardiac patients and was limited by the individuals’ extreme body weight. Since relative weight was shown to be an insensitive measure of obesity, it is recommended that percent fat be measured and used as a means to determine eligibility for gastric bypass surgery. Further study of these individuals is warranted in order to determine what effects large weight loss following surgery will have on parameters of body composition and aerobic capacity. Understanding how large weight loss affects these parameters will aid in designing effective postsurgical exercise rehabilitative programs for future patients.

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