scholarly journals The good, the bad and NLRP3-chracterizing novel roles for the inflammasome in adipose- tissue biology and burn trauma

Endocrinology ◽  
2021 ◽  
Author(s):  
Lori Asarian
Keyword(s):  
Adipose Tissue ◽  
Burn Trauma ◽  
Tissue Biology

scholarly journals Chemotactic cytokines, obesity and type 2 diabetes:in vivoandin vitroevidence for a possible causal correlation?

2009 ◽  
Vol 68 (4) ◽  
pp. 378-384 ◽  
Author(s):  
Henrike Sell ◽  
Jürgen Eckel
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Low Grade ◽  
Obese Patients ◽  
Tissue Mass ◽  
Tissue Biology ◽  
Wide Range ◽  
Adipose Tissue Mass

A strong causal link between increased adipose tissue mass and insulin resistance in tissues such as liver and skeletal muscle exists in obesity-related disorders such as type 2 diabetes. Increased adipose tissue mass in obese patients and patients with diabetes is associated with altered secretion of adipokines, which also includes chemotactic proteins. Adipose tissue releases a wide range of chemotactic proteins including many chemokines and chemerin, which are interesting targets for adipose tissue biology and for biomedical research in obesity and obesity-related diseases. This class of adipokines may be directly linked to a chronic state of low-grade inflammation and macrophage infiltration in adipose tissue, a concept intensively studied in adipose tissue biology in recent years. The inflammatory state of adipose tissue in obese patients may be the most important factor linking increased adipose tissue mass to insulin resistance. Furthermore, chemoattractant adipokines may play an important role in this situation, as many of these proteins possess biological activity beyond the recruitment of immune cells including effects on adipogenesis and glucose homeostasis in insulin-sensitive tissues. The present review provides a summary of experimental evidence of the role of adipose tissue-derived chemotactic cytokines and their function in insulin resistancein vivoandin vitro.

Pro-resolving actions of SPM in adipose tissue biology

2017 ◽  
Vol 58 ◽  
pp. 83-92 ◽  
Author(s):  
Joan Clària ◽  
Cristina López-Vicario ◽  
Bibiana Rius ◽  
Esther Titos
Keyword(s):  
Adipose Tissue ◽  
Tissue Biology

Waisted: The Biology of Body Fat

2021 ◽  
Author(s):  
Nathan Denton
Keyword(s):  
Adipose Tissue ◽  
Body Fat ◽  
Fat Distribution ◽  
Passive Layer ◽  
Evidence Based ◽  
Physical And Mental Health ◽  
Tissue Biology ◽  
Adipose Tissue Dysfunction ◽  
Social Meanings ◽  
Practical Implications

Waisted outlines the fascinating and misunderstood biology of fat (i.e., adipose tissue). This controversial, much-maligned organ plays a crucial yet curiously overlooked role in the global obesity crisis currently wreaking havoc on the world’s healthcare systems and economies. Attaining a better appreciation of the biology of fat, its social meanings, and how these intersect is essential for improving the world’s physical and mental health. Far from being a passive layer of blubber under the skin, fat plays a highly dynamic role in energy metabolism, reproductive health, and immunity, with these links having ancient origins in the evolution of modern humanity. Waisted provides a comprehensive, evidence-based perspective on the biology of fat and its crucial role in human evolution, health, disease, and society. Waisted draws upon biomedical, epidemiological, and evolutionary research to understand adipose tissue biology and the striking relationship between body fat distribution and health outcomes. Waisted demonstrates the practical implications of key conceptual points through relatable real-world cases and highlights how seemingly disparate common and rare diseases may be underpinned by adipose tissue dysfunction. Overall, Waisted covers a wide breadth of material that challenges and reframes the generally negative perspective of fat to highlight the underappreciated importance of adipose tissue biology in humans.

Omega-3 fatty acids and adipose tissue biology

2018 ◽  
Vol 64 ◽  
pp. 147-160 ◽  
Author(s):  
Ondrej Kuda ◽  
Martin Rossmeisl ◽  
Jan Kopecky
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Tissue Biology

scholarly journals The Role of Adipose Tissue in Insulin Resistance in Women of African Ancestry

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Julia H. Goedecke ◽  
Naomi S. Levitt ◽  
Juliet Evans ◽  
Nicole Ellman ◽  
David John Hume ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
White Women ◽  
African Ancestry ◽  
Fat Distribution ◽  
Future Research ◽  
Industrialized Countries ◽  
Tissue Biology ◽  
Ectopic Fat Deposition

Women of African ancestry, particularly those living in industrialized countries, experience a disproportionately higher prevalence of type 2 diabetes (T2D) compared to their white counterparts. Similarly, obesity and insulin resistance, which are major risk factors for T2D, are greater in black compared to white women. The exact mechanisms underlying these phenomena are not known. This paper will focus on the role of adipose tissue biology. Firstly, the characteristic body fat distribution of women of African ancestry will be discussed, followed by the depot-specific associations with insulin resistance. Factors involved in adipose tissue biology and their relation to insulin sensitivity will then be explored, including the role of sex hormones, glucocorticoid metabolism, lipolysis and adipogenesis, and their consequent effects on adipose tissue hypoxia, oxidative stress, and inflammation. Finally the role of ectopic fat deposition will be discussed. The paper proposes directions for future research, in particular highlighting the need for longitudinal and/or intervention studies to better understand the mechanisms underlying the high prevalence of insulin resistance and T2D in women of African ancestry.

scholarly journals Vitamin A Metabolism and Adipose Tissue Biology

Nutrients ◽  
2011 ◽  
Vol 3 (1) ◽  
pp. 27-39 ◽  
Author(s):  
Simone K. Frey ◽  
Silke Vogel
Keyword(s):  
Adipose Tissue ◽  
Vitamin A ◽  
Vitamin A Metabolism ◽  
Tissue Biology
Sign in / Sign up

Export Citation Format

Share Document