scholarly journals Deiodinases: how non-mammalian research helped shape our present view

Endocrinology ◽  
2021 ◽  
Author(s):  
Veerle M Darras
Keyword(s):  
Comparative Research ◽  
Biochemical Properties ◽  
The Body ◽  
Whole Body ◽  
Iodothyronine Deiodinases ◽  
Local Functions ◽  
Variation Data ◽  
The Impact ◽  
Seasonal Rhythmicity ◽  
Present View

Abstract Iodothyronine deiodinases are enzymes capable of activating and inactivating thyroid hormones (THs) and have an important role in regulating TH action in tissues throughout the body. Three types of deiodinases (D1, D2 and D3) were originally defined based on their biochemical characteristics. Cloning of the first cDNAs in the 1990s (Dio1 in rat and dio2 and dio3 in frog) allowed to confirm the existence of three distinct enzymes. Over the years, increasing genomic information revealed that deiodinases are present in all chordates, vertebrates and non-vertebrates, and that they can even be found in some mollusks and annelids, pointing to an ancient origin. Research in non-mammalian models has substantially broadened our understanding of deiodinases. In relation to their structure, we discovered for instance that biochemical properties such as inhibition by 6-propyl-2-thiouracil, stimulation by dithiothreitol and temperature optimum are subject to variation. Data from fish, amphibians and birds were key in shifting our view on the relative importance of activating and inactivating deiodination pathways, and in showing the impact of D2 and D3 not only in local but also whole body T3 availability. They also led to the discovery of new local functions such as the acute reciprocal changes in D2 and D3 in hypothalamic tanycytes upon photostimulation, involved in seasonal rhythmicity. With the present possibilities for rapid and precise gene silencing in any species of interest, comparative research will certainly further contribute to a better understanding of the importance of deiodinases for adequate TH action, also in humans.

Just Skin and Bones: The Longing for Wholeness of the Body in the Book of Job

2008 ◽  
Vol 58 (3) ◽  
pp. 287-299 ◽  
Author(s):  
Alec Basson
Keyword(s):  
Social Relations ◽  
The Body ◽  
Whole Body ◽  
Book Of Job ◽  
Personal Loss ◽  
Ancient Israel ◽  
Social Unity ◽  
Ideal Body Image ◽  
Ideal Body ◽  
The Impact

AbstractThe book of Job recounts the story of an individual who grapples with the enigma of suffering. In addition to his personal loss, the supplicant's body also comes under attack. Furthermore, the physical distress experienced by Job is exacerbated by the attitude of his kinsmen. His disintegrated body has lead to severed social relations. Given the fact that the body mediates the plaintiff's involvement in society and represented social unity in ancient Israel, Job longs for a whole body as the ideal body image. The ancient Israelites only regarded the whole body as pure, real and acceptable. This contribution argues that to appreciate fully the allusions to bodily degeneration in the book of Job, the importance of wholeness of the physical body in ancient Israel and the impact it had on the socio-religious structure should be taken into account.

scholarly journals Impact of Engaging the Nonthrowing Arm on Maximal Ball Velocity From an Overhand Throw With Both the Dominant and Nondominant Arms: A Pilot Study

2021 ◽  
pp. 1-18
Author(s):  
Alanna Weisberg ◽  
Hyun Suk Lee ◽  
Tak Fung ◽  
Larry Katz
Keyword(s):  
The Body ◽  
Whole Body ◽  
Camera Motion ◽  
Ball Speed ◽  
Kinematic Data ◽  
Overhand Throw ◽  
Ball Velocity ◽  
Analysis System ◽  
The Impact ◽  
Camera Motion Analysis

The overhand throw is a complex whole-body motor skill that is fundamental to many sports and activities. When throwing properly, the momentum generated to complete the movement begins in the lower body and transfers through the trunk to the throwing arm. This proof-of-concept study’s primary purpose was to evaluate the impact of the nonthrowing arm on the ball speed during an overhand throw with both the dominant and nondominant arms. Eighteen participants (age: 20.20 ± 2.90 years, nine women) were divided into two intervention groups: a pulling group taught to engage the nonthrowing arm through a pull toward the body and a nonpulling group taught the overhand throw using a component-based physical education curriculum. Each participant completed 12 total throws, six for each side (dominant and nondominant arm). Ball speed and kinematic data were collected using an eight-camera motion analysis system and were assessed using a pre–post study design. The two groups showed significant improvements pre–post when throwing with both the dominant and nondominant arms. Based on effect size comparisons, engaging the nonthrowing arm makes a meaningful difference in maximal ball velocity.

scholarly journals Interpersonal synchrony feels good but impedes self-regulation of affect

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Laura Galbusera ◽  
Michael T. M. Finn ◽  
Wolfgang Tschacher ◽  
Miriam Kyselo
Keyword(s):  
Positive Affect ◽  
Self Regulation ◽  
The Body ◽  
Whole Body ◽  
Beneficial Effects ◽  
Interpersonal Synchrony ◽  
The Social ◽  
Widespread Belief ◽  
The Stability ◽  
The Impact

Abstract The social benefits of interpersonal synchrony are widely recognized. Yet, little is known about its impact on the self. According to enactive cognitive science, the human self for its stability and regulation needs to balance social attunement with disengagement from others. Too much interpersonal synchrony is considered detrimental for a person’s ability to self-regulate. In this study, 66 adults took part in the Body-Conversation Task (BCT), a dyadic movement task promoting spontaneous social interaction. Using whole-body behavioural imaging, we investigated the simultaneous impact of interpersonal synchrony (between persons) and intrapersonal synchrony (within a person) on positive affect and self-regulation of affect. We hypothesized that interpersonal synchrony’s known tendency to increase positive affect would have a trade-off, decreasing a person’s ability to self-regulate affect. Interpersonal synchrony predicted an increase in positive affect. Consistent with our hypothesis, it simultaneously predicted a weakening in self-regulation of affect. Intrapersonal synchrony, however, tended to oppose these effects. Our findings challenge the widespread belief that harmony with others has only beneficial effects, pointing to the need to better understand the impact of interaction dynamics on the stability and regulation of the human self.

scholarly journals Iodothyronine deiodinase structure and function: from ascidians to humans

2012 ◽  
Vol 215 (2) ◽  
pp. 189-206 ◽  
Author(s):  
Veerle M Darras ◽  
Stijn L J Van Herck
Keyword(s):  
Developmental Stages ◽  
The Body ◽  
Thyroid Status ◽  
Iodothyronine Deiodinase ◽  
Relative Contribution ◽  
Iodothyronine Deiodinases ◽  
Different Types ◽  
And Function ◽  
The Impact

Iodothyronine deiodinases are important mediators of thyroid hormone (TH) action. They are present in tissues throughout the body where they catalyse 3,5,3′-triiodothyronine (T3) production and degradation via, respectively, outer and inner ring deiodination. Three different types of iodothyronine deiodinases (D1, D2 and D3) have been identified in vertebrates from fish to mammals. They share several common characteristics, including a selenocysteine residue in their catalytic centre, but show also some type-specific differences. These specific characteristics seem very well conserved for D2 and D3, while D1 shows more evolutionary diversity related to itsKm, 6-n-propyl-2-thiouracil sensitivity and dependence on dithiothreitol as a cofactorin vitro. The three deiodinase types have an impact on systemic T3levels and they all contribute directly or indirectly to intracellular T3availability in different tissues. The relative contribution of each of them, however, varies amongst species, developmental stages and tissues. This is especially true for amphibians, where the impact of D1 may be minimal. D2 and D3 expression and activity respond to thyroid status in an opposite and conserved way, while the response of D1 is variable, especially in fish. Recently, a number of deiodinases have been cloned from lower chordates. Both urochordates and cephalochordates possess selenodeiodinases, although they cannot be classified in one of the three vertebrate types. In addition, the cephalochordate amphioxus also expresses a non-selenodeiodinase. Finally, deiodinase-like sequences have been identified in the genome of non-deuterostome organisms, suggesting that deiodination of externally derived THs may even be functionally relevant in a wide variety of invertebrates.

scholarly journals Closed-Loop Multiscale Computational Model of Human Blood Circulation. Applications to Ballistocardiography

2021 ◽  
Vol 12 ◽  
Author(s):  
Jeremy Rabineau ◽  
Antoine Nonclercq ◽  
Tim Leiner ◽  
Philippe van de Borne ◽  
Pierre-Francois Migeotte ◽  
...  
Keyword(s):  
Computational Model ◽  
Human Blood ◽  
Blood Circulation ◽  
Closed Loop ◽  
Scaling Law ◽  
The Body ◽  
Whole Body ◽  
Mechanical Activity ◽  
Clinical Records ◽  
The Impact

Cardiac mechanical activity leads to periodic changes in the distribution of blood throughout the body, which causes micro-oscillations of the body’s center of mass and can be measured by ballistocardiography (BCG). However, many of the BCG findings are based on parameters whose origins are poorly understood. Here, we generate simulated multidimensional BCG signals based on a more exhaustive and accurate computational model of blood circulation than previous attempts. This model consists in a closed loop 0D-1D multiscale representation of the human blood circulation. The 0D elements include the cardiac chambers, cardiac valves, arterioles, capillaries, venules, and veins, while the 1D elements include 55 systemic and 57 pulmonary arteries. The simulated multidimensional BCG signal is computed based on the distribution of blood in the different compartments and their anatomical position given by whole-body magnetic resonance angiography on a healthy young subject. We use this model to analyze the elements affecting the BCG signal on its different axes, allowing a better interpretation of clinical records. We also evaluate the impact of filtering and healthy aging on the BCG signal. The results offer a better view of the physiological meaning of BCG, as compared to previous models considering mainly the contribution of the aorta and focusing on longitudinal acceleration BCG. The shape of experimental BCG signals can be reproduced, and their amplitudes are in the range of experimental records. The contributions of the cardiac chambers and the pulmonary circulation are non-negligible, especially on the lateral and transversal components of the velocity BCG signal. The shapes and amplitudes of the BCG waveforms are changing with age, and we propose a scaling law to estimate the pulse wave velocity based on the time intervals between the peaks of the acceleration BCG signal. We also suggest new formulas to estimate the stroke volume and its changes based on the BCG signal expressed in terms of acceleration and kinetic energy.

MO662EFFECT OF ARTERIOVENOUS VASCULAR ACCESS ON BIOIMPEDANCE MEASUREMENTS IN HEMODIALYSIS PATIENTS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Lin-Chun Wang ◽  
Fansan Zhu ◽  
Ohnmar Thwin ◽  
Priscila Preciado Rojas ◽  
Laura Rosales Merlo ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Objective Assessment ◽  
Fluid Management ◽  
The Body ◽  
Whole Body ◽  
Large Contribution ◽  
Fluid Status ◽  
Single Side ◽  
The Difference ◽  
The Impact

Abstract Background and Aims Fluid management remains a major problem in hemodialysis (HD) patients, partly because of the lack of objective assessment methods. Many methods have been proposed to estimate the fluid status in HD patients and bioimpedance has established as one of the most popular clinical tools. Resistance to alternate current was found to be lower in the arteriovenous (AV) access-bearing side compared with the non-access side in post-HD bioimpedance measurements. We hypothesized this difference between access and non-access sides can be seen in both pre- and post-HD measurements of arms and whole body. The aim of the study was to investigate whether this variation between access and non-access sides could affect single-side whole body measurements. Method Pre- and post-HD bioimpedance measurements with two 8-point devices (InBody 770 and Seca mBCA 514) were performed in 11 HD patients with functioning AV access in the arm (8 male, pre-HD 75.4 ± 13.6 kg, post-HD 72.8 ± 13.5 kg). Values of resistance at 5 kHz (R5) in the arm and whole body (R5 of arm + trunk + leg on the same side) were extracted. Whole-body extracellular water (ECW) was calculated using whole-body R5 by the Xitron equation* to evaluate how measuring only one side of the body can affect the fluid volume calculation. Results The R5 of the arm on the access side was lower compared with the non-access side both pre- and post-HD (P < 0.01), measured by InBody. The same was seen with the Seca but did not reach statistical significance (Table 1). The estimated whole-body ECW was higher on the access side for InBody (P < 0.01). With Seca, the same trend was seen but remained non-significant. While the difference in ECW between both arms reported by InBody was small, the impact on calculated whole-body ECW was much larger with a difference between sides of 0.50 ± 0.82 L pre HD and 0.55 ± 0.81 L post HD. Conclusion InBody appears to pick up the difference in fluid status between the access and non-access side with greater precision than Seca. The large contribution of the arm to whole-body resistance amplifies the impact of the presence of an AV access on whole-body ECW estimations based on single-side wrist-to-ankle bioimpedance measurements. Eight-point bioimpedance devices (like the tested InBody and Seca) measure both sides of the body, so, choice of measurement side does not enter the picture.

The impact of regular long term physical load on cardiovascular functional parameters in children and adolescent athletes

2013 ◽  
Vol 23 (1) ◽  
pp. 53-59
Author(s):  
Aldona Bartkevičienė ◽  
Dalia Bakšienė ◽  
Pranas Šerpytis
Keyword(s):  
Blood Pressure ◽  
Children And Adolescents ◽  
Cardiovascular System ◽  
The Body ◽  
Physical Load ◽  
Whole Body ◽  
Human Organism ◽  
Control Group ◽  
Functional Parameters ◽  
The Impact

Introduction. Regular physical load determines increase in functional capability of cardiovascular system. On the other hand, the cardiovascular system often appears as a conditional factor, which restricts organism adaptive abilities and limits general organism adaptation to the load. During physical load, not only cardiovascular system is activated, but also complex changes take place in the whole body. Therefore, with the aim to evaluate the functions of various systems, interrelation between them and systemic response of the body to physical load, a complex research on distinctive features of not only functional indices of the cardiovascular system, but also parameters reflecting interrelationship among functional systems of the body and speed of their changes is carried out. The goal of such complex research is the evaluation of adaptive and reserve capabilities of the athlete’s body and individualization and optimization of physical load. The aim of this study was to evaluate the speed of changes of parameters that characterize the functional condition of human organism of children and adolescents athletes and non-athletes controls. Materials and methods. One hundred sixty seven male athletes aged 14.8 (SD1.6, range 12-17 years) participating in basketball, rowing and cycling and168 healthy sedentary controls matched for age, sex and body surface area performed a graded exercise test (Mc. Master) on a cycle ergo-meter. 12 ECG standard derivations were synchronously recorded every second minute. During cycle ergo-meter integrated functional parameters, which could integrally and simple evaluate organism reaction to physical load, were assessed.Results. The present study demonstrates that before reaching the maximum of physical load, the speed of changes JT/RR in athletes and all functional parameters (HR, JT interval, RR interval, systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse blood pressure (SBP-DBP), JT/RR ratio) in the control group decreased and in the last step of physical load has increased. That suggests that during intensive exercise training limits of physiological changes can be exceeded in athletes. Conclusions. Analysis of speed of changes in functional parameters during physical load can be applied for the evaluation of functional state of the human body and the cardiovascular system and aiming to optimize and individualize physical load in athletic children and adolescents.

scholarly journals Enhancing cooling performance via airflow temperature fluctuations

2019 ◽  
Vol 111 ◽  
pp. 02072 ◽  
Author(s):  
Žiga Lampret ◽  
Gorazd Krese ◽  
Matjaž Prek
Keyword(s):  
Skin Temperature ◽  
Thermal Sensation ◽  
Human Perception ◽  
Temperature Fluctuations ◽  
Rate Of Change ◽  
Point Of View ◽  
The Body ◽  
Whole Body ◽  
Air Movement ◽  
The Impact

In ventilated and air-conditioned indoor environment, air movement substantially impacts thermal sensation and comfort of occupants from the point of view of whole body and local thermal sensation. Skin temperature and its rate of change are important factors for thermal sensation. Both are affected by the airflow velocity and temperature changes around the body which causes skin temperature fluctuations and changes in convective heat transfer. In this study the impact of temperature fluctuations in airflow on human thermal sensation was examined. For the purposes of the study, an air handling unit was designed for generating airflows with temperature fluctuations and used in a subjective experiment. The experimental study indicates that temperature fluctuations possibly influence the human perception of air movement with a distinct cooling effect.

scholarly journals 004.From molecules to mind: stress, allostasis and integration of brain and body

2004 ◽  
Vol 16 (9) ◽  
pp. 4
Author(s):  
B. McEwen
Keyword(s):  
Life Style ◽  
Allostatic Load ◽  
The Body ◽  
Stressful Events ◽  
Whole Body ◽  
Human Society ◽  
Wear And Tear ◽  
The Mind ◽  
The Impact ◽  
Physiological Systems

The mind involves the whole body and two-way communication between the brain and the cardiovascular, immune and other systems via neural and endocrine mechanisms. Stress is a condition of the mind and a factor in the expression of disease that differs among individuals. A broader view is that it is not just the dramatic stressful events that exact their toll but rather the many events of daily life that elevates activities of physiological systems so as to cause some measure of wear and tear. We call this wear and tear 'allostatic load', and it reflects not only the impact of life experiences but also genetic load' individual life-style habits reflecting items such as diet, exercise and substance abuse' and developmental experiences that set life-long patterns of behavior and physiological reactivity (1). Hormones associated with stress and allostatic load protect the body in the short-run and promote adaptation, but the long run allostatic load causes changes in the body that lead to disease. This will be illustrated for the immune system and brain regions involved in stress, fear and cognition (e.g. hippocampus, amygdala and prefrontal cortex). Besides developmental influences associated with mother–infant interactions, the most potent of stressors in adult life are those arising from competitive interactions between animals of the same species, leading to the formation of dominance hierarchies. Psychosocial stress of this type not only impairs cognitive function of lower ranking animals, but it can also promote disease (e.g. atherosclerosis) among those vying for the dominant position, as well as depressive illness. Social ordering in human society is also associated with gradients of disease, with an increasing frequency or mortality and morbidity as one descends the scale of socioeconomic status (SES) that reflects both income and education. Although the causes of these gradients of health are very complex, they are likely to reflect, with increasing frequency at the lower end of the scale, the cumulative burden of coping with limited resources and negative life events as well as differences in life style, and the allostatic load that this burden places on the physiological systems involved in adaptation and coping. (1) McEwen, B.S. (1998) Protective and damaging effects of stress mediators. New England J. Med. 238, 171–179.

scholarly journals Effect of core muscle exercises on subcutaneous fat percentage of Badminton players

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Gottigundala Shyam mohan Reddy ◽  
Rathikota Rajeswari
Keyword(s):  
Subcutaneous Fat ◽  
The Body ◽  
Core Stability ◽  
Whole Body ◽  
Fat Percentage ◽  
Significant Difference ◽  
Before And After ◽  
Post Test ◽  
And Control ◽  
The Impact

Badminton involves jumping to reach a shuttle at the highest possible point when descending for a better stroke as in a smash and drop shot. Hence the body weight has to be lifted repeatedly against gravity, where the extra mass in the form of fat would be disadvantage. Moreover the fat tends to be localized in the trunk and lower body segments. Core stability is defined in athletic setting as the optimum production, which can transfer and control the force from the centre of the body to the limbs, through stabilization of the position and motion of torso. Core stability exercises are an essential fitness component of badminton players during smashing the shuttlecock through the game.The present study was conducted to assess the impact of core muscle exercises on subcutaneous fat percentage of badminton players. To achieve this purpose Twenty five badminton players were included in the study, whose age ranged from 17-21 years. During training ten core muscle exercises were performed with one minute each exercise and twenty seconds break in between the exercise. This is performed for three sets. This training is continued for 6 days in a week with one session per day for four weeks. The subcutaneous fat percentage at Arms, Trunk, Legs and Whole body was measured using the Omron HBF 375 Karada Scan before and after the training. The obtained pre and post test data were statistically analyzed using the ‘t’ test. Results shows that there is significant difference in the subcutaneous fat percentage at Arms, Trunk, Legs and Whole body of the badminton players.

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