scholarly journals Potential Interaction Between SARS-CoV-2 and Thyroid: A Review

Endocrinology ◽  
2021 ◽  
Vol 162 (3) ◽  
Author(s):  
Wenjie Chen ◽  
Yuang Tian ◽  
Zhihui Li ◽  
Jingqiang Zhu ◽  
Tao Wei ◽  
...  
Keyword(s):  
Disease Burden ◽  
Negative Impact ◽  
Potential Interaction ◽  
Thyroid Diseases ◽  
The Novel ◽  
Epidemic Period ◽  
Novel Coronavirus ◽  
Short Time ◽  
And Control ◽  
First Time

Abstract The novel coronavirus disease 2019 (COVID-19) produced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is sweeping the world in a very short time. Although much has been learned about the clinical course, prognostic inflammatory markers, and disease complications of COVID-19, the potential interaction between SARS-CoV-2 and the thyroid is poorly understood. In contrast to SARS-CoV-1, limited available evidence indicates there is no pathological evidence of thyroid injury caused by SARS-CoV-2. However, subacute thyroiditis caused by SARS-CoV-2 has been reported for the first time. Thyroid dysfunction is common in patients with COVID-19 infection. By contrast, certain thyroid diseases may have a negative impact on the prevention and control of COVID-19. In addition, some anti–COVID-19 agents may cause thyroid injury or affect its metabolism. COVID-19 and thyroid disease may mutually aggravate the disease burden. Patients with SARS-CoV-2 infection should not ignore the effect on thyroid function, especially when there are obvious related symptoms. In addition, patients with thyroid diseases should follow specific management principles during the epidemic period.

scholarly journals Consideration of the Management of Pediatric Fever Clinics During the Novel Coronavirus Pneumonia Outbreak

2020 ◽  
pp. 1-7
Author(s):  
Hui Ding ◽  
Zhaoling Shi ◽  
Zhen Ruan ◽  
Xiaoning Cheng ◽  
Ruying Li ◽  
...  
Keyword(s):  
Medical Staff ◽  
Prevention And Control ◽  
Cross Infection ◽  
The Novel ◽  
Wuhan City ◽  
Control Programs ◽  
Treatment And Prevention ◽  
Epidemic Period ◽  
Novel Coronavirus ◽  
And Control

ABSTRACT Since the outbreak of 2019 novel coronavirus (2019-nCoV) infection in Wuhan City, China, pediatric cases have gradually increased. It is very important to prevent cross-infection in pediatric fever clinics, to identify children with fever in pediatric fever clinics, and to strengthen the management of pediatric fever clinics. According to prevention and control programs, we propose the guidance on the management of pediatric fever clinics during the nCoV pneumonia epidemic period, which outlines in detail how to optimize processes, prevent cross-infection, provide health protection, and prevent disinfection of medical staff. The present consideration statement summarizes current strategies on the pre-diagnosis, triage, diagnosis, treatment, and prevention of 2019-nCoV infection, which provides practical suggestions on strengthening the management of pediatric fever clinics during the nCoV pneumonia epidemic period.

scholarly journals Multi-Objective Optimization of Integrated Civilian-Military Scheduling of Medical Supplies for Epidemic Prevention and Control

Healthcare ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 126
Author(s):  
Hai-Feng Ling ◽  
Zheng-Lian Su ◽  
Xun-Lin Jiang ◽  
Yu-Jun Zheng
Keyword(s):  
Prevention And Control ◽  
Large Scale ◽  
Medical Services ◽  
The Novel ◽  
Multi Objective ◽  
Medical Supplies ◽  
Problem Instances ◽  
Novel Coronavirus ◽  
And Control ◽  
Minimum Ratio

In a large-scale epidemic, such as the novel coronavirus pneumonia (COVID-19), there is huge demand for a variety of medical supplies, such as medical masks, ventilators, and sickbeds. Resources from civilian medical services are often not sufficient for fully satisfying all of these demands. Resources from military medical services, which are normally reserved for military use, can be an effective supplement to these demands. In this paper, we formulate a problem of integrated civilian-military scheduling of medical supplies for epidemic prevention and control, the aim of which is to simultaneously maximize the overall satisfaction rate of the medical supplies and minimize the total scheduling cost, while keeping a minimum ratio of medical supplies reservation for military use. We propose a multi-objective water wave optimization (WWO) algorithm in order to efficiently solve this problem. Computational results on a set of problem instances constructed based on real COVID-19 data demonstrate the effectiveness of the proposed method.

scholarly journals A Study On Financial Self-Efficacy During Covid-19

2021 ◽  
Vol 23 (08) ◽  
pp. 472-483
Author(s):  
Sitangshu Khatua ◽  
◽  
Debdulal Dutta Roy ◽  
Keyword(s):  
Self Efficacy ◽  
Principal Component ◽  
The Novel ◽  
The Great Depression ◽  
Online Mode ◽  
Personal Finances ◽  
Study Results ◽  
Financial Goal ◽  
Novel Coronavirus ◽  
And Control

Financial Self-efficacy is defined as a person’s observed capability to control his/her personal finances (Lapp, 2010; Postmus, 2011). It refers to one’s beliefs in the abilities to accomplish a financial goal or task. It is the “knowledge and ability to influence and control one’s financial matters” by Fox and Bartholomae (2008). Financial efficacy pattern of people during very critical moment is unknown. The world is experiencing one of the deepest recessions since the Great Depression in the 1930s owing to the novel coronavirus, World Bank President David Malpass has said, terming the COVID-19 pandemic a “catastrophic event” for many developing and the poorest countries. Aim of the study is to examine financial efficacy pattern of people during lockdown period for COVID-19. Data were collected through online mode using financial efficacy scale developed by authors for the study. Results of principal component analysis revealed that during lockdown, financial efficacy is more concerned with financial planning, planned payment and financial coping.

Application of Early Warning Nursing System During COVID-19 Epidemic in Children’s Hospital

Nano LIFE ◽  
2021 ◽  
pp. 2140004
Author(s):  
Wenying Yao ◽  
Jinxia Yang ◽  
Xin Wang ◽  
Min Shen
Keyword(s):  
Early Warning ◽  
Early Warning System ◽  
Warning System ◽  
Popular Science ◽  
The Novel ◽  
Children's Hospital ◽  
Hospital Nursing ◽  
Children’S Hospital ◽  
Novel Coronavirus ◽  
And Control

Aim: To develop a nursing early warning system in children’s hospital during the outbreak of the novel coronavirus pneumonia, and to accomplish the construction and application of this system, so as to provide decision-support of the prevention and control for COVID-19 in children’s medical institutions. Method: Children’s hospital nursing early warning system was divided into three modules: hospital nursing early warning platform includes internal and external early warning platform, nursing staff early warning program includes protection, human resources early warning plan and patient early warning program includes outpatient, emergency and ward early warning plan. The data of epidemic training, assessment, prevention and control screening from January to June 2020 were collected from the nursing early warning system to evaluate the application effect of the system. Results: A total of 18 procedures and specifications were formulated, nine hospital-level trainings and about 1000 department-level trainings were organized, two hospital-level assessments (pass rate 95.6% and 98.2%), and 78 nurses were reserved, and 10 popular science articles, five popular science videos were published during the application of the nursing early warning system. A total of 583,435 children and 139,308 caregivers were screened in outpatient, emergency and wards during pre-checks, 2385 suspected cases of novel coronavirus pneumonia were confirmed (0.41%) after the screening and 1 case (0.0002%) was finally confirmed. Conclusion: The nursing early warning system of children’s hospital can prevent and control the novel coronavirus pneumonia epidemic from each module, ensure early warning and triage of suspected infected patients, reduce the risk of cross-infection in hospital and improve the safety of the children’s hospital medical environment.

scholarly journals The Online Education Mode and Reopening Plans for Chinese Schools During the COVID-19 Pandemic: A Mini Review

2020 ◽  
Vol 8 ◽  
Author(s):  
Xuanzhen Cen ◽  
Dong Sun ◽  
Ming Rong ◽  
Gusztáv Fekete ◽  
Julien S. Baker ◽  
...  
Keyword(s):  
Online Education ◽  
Prevention And Control ◽  
World Health ◽  
Classroom Teaching ◽  
Full Time ◽  
The Novel ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization ◽  
And Control

Recently, an unprecedented coronavirus pandemic has emerged and has spread around the world. The novel coronavirus termed COVID-19 by the World Health Organization has posed a huge threat to human safety and social development. This mini review aimed to summarize the online education mode and plans for schools to resume full-time campus study in China during COVID-19. Chinese schools have made significant contributions to the prevention and control of the transmission of COVID-19 by adopting online learning from home. However, normal opening and classroom teaching have been affected. For education systems at all levels, online education may be an effective way to make up for the lack of classroom teaching during the epidemic. To protect staff and students from COVID-19, the timing of students returning to full-time campus study needs to be considered carefully. Reviewing and summarizing of the Chinese education system's response to the virus would be of great value not only in developing educational policy but also in guiding other countries to formulate educational countermeasures.

scholarly journals Exploring the role and mechanism of COVID-19 apps in fighting the current pandemic

2020 ◽  
Vol 0 ◽  
pp. 1-6
Author(s):  
Karthikeyan P. Iyengar ◽  
Rachit Jain ◽  
David Ananth Samy ◽  
Vijay Kumar Jain ◽  
Raju Vaishya ◽  
...  
Keyword(s):  
Data Privacy ◽  
Viral Transmission ◽  
Contact Tracing ◽  
The Novel ◽  
Test Track ◽  
The World ◽  
Novel Coronavirus ◽  
And Control ◽  
Second Wave ◽  
Transmission Test

As COVID-19 pandemic spread worldwide, policies have been developed to contain the disease and prevent viral transmission. One of the key strategies has been the principle of “‘test, track, and trace” to minimize spread of the virus. Numerous COVID-19 contact tracing applications have been rolled around the world to monitor and control the spread of the disease. We explore the characteristics of various COVID-19 applications and especially the Aarogya Setu COVID-19 app from India in its role in fighting the current pandemic. We assessed the current literature available to us using conventional search engines, including but not limited to PubMed, Google Scholar, and Research Gate in May 2020 till the time of submission of this article. The search criteria used MeSH keywords such as “COVID-19,” “pandemics,” “contact tracing,” and “mobile applications.” A variable uptake of different COVID-19 applications has been noted with increasing enrolment around the world. Security concerns about data privacy remain. The various COVID-19 applications will complement manual contact tracing system to assess and prevent viral transmission. Test, track, trace, and support policy will play a key role in avoidance of a “second wave” of the novel coronavirus severe acute respiratory syndrome coronavirus 2 outbreak.

scholarly journals How far Covid19 virus spread can be curbed by relaxing lockdown in different stages? -A study in Indian scenario

2020 ◽  
Author(s):  
Arindom Chakraborty ◽  
Kalyan Das
Keyword(s):  
Simulated Data ◽  
The Novel ◽  
Short Term ◽  
Time Points ◽  
Term Forecast ◽  
Novel Coronavirus ◽  
And Control ◽  
Near Future ◽  
Different Levels ◽  
Indian Scenario

ABSTRACTAfter the emergence of the first cases in Wuhan, China, the novel coronavirus (2019-nCoV) infection has rapidly spread out to other provinces, neighboring countries and finally has become a global terror. It is indeed a matter of serious concern to study the transmission dynamics of this virus. The potential and severity of an outbreak and providing critical information for identifying the type of disease interventions and intensity can be well understood by the unknown basic reproduction number. A stochastic model can be used to estimate this number with possible safeguard on uncertainties. It is essential to assess how the expensive, resource-intensive measures can contribute to the prevention and control of the 2019-nCoV infection and how long they should be maintained. A short-term forecast of incidences are often of high priority. The challenge is to forecast unseen “future” simulated data for three different scenarios at some time points. We estimate current levels of transmissibility, over variable time points under different levels of interventions and use that to forecast near-future incidence. The forecasted values of incidence can be used for determining the near future mortality also.

scholarly journals How to Dispose of Medical Waste Caused by COVID-19? A Case Study of China

2021 ◽  
Vol 18 (22) ◽  
pp. 12127
Author(s):  
Min Su ◽  
Qiang Wang ◽  
Rongrong Li
Keyword(s):  
Waste Disposal ◽  
Medical Waste ◽  
Chinese Government ◽  
The Novel ◽  
Global Epidemic ◽  
Medical Institutions ◽  
Process System ◽  
The Government ◽  
Novel Coronavirus ◽  
And Control

The rapid increase in novel coronavirus (COVID-19) patients also means a rapid increase in medical waste that could carry the novel coronavirus (SARS-CoV-2). How to safely dispose of medical waste caused by COVID-19 is a huge challenge that needs to be solved urgently. The outbreak of the COVID-19 has led to a significant increase in the daily generation of medical waste in China and has placed a severe test on the Chinese medical waste disposal system. Unlike ordinary wastes and garbage, medical waste that is untreated or incompletely treated will not only cause environmental pollution, but also directly or indirectly cause infections and endanger people’s health. Faced with difficulties, the Chinese government formulated a policy for medical waste management and a response plan for the epidemic, which provides policy guarantee for the standardized disposal of epidemic medical waste. In addition, the government and medical institutions at all levels formed a comprehensive, refined, and standardized medical treatment process system during research and practice. China has increased the capacity of medical waste disposal in various places by constructing new centralized disposal centers and adding mobile disposal facilities. China has achieved good results in the fight against COVID-19, and the pressure on medical waste disposal has been relieved to a certain extent. However, the global epidemic situation is severe. How to ensure the proper and safe disposal of medical waste is related to the prevention and control of the epidemic situation. This study summarizes China’s experience in the disposal of medical waste in the special case of COVID-19 and hopes to provide some reference for other countries in the disposal of medical waste.

scholarly journals The IMPDH inhibitor merimepodib provided in combination with the adenosine analogue remdesivir reduces SARS-CoV-2 replication to undetectable levels in vitro

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 361
Author(s):  
Natalya Bukreyeva ◽  
Rachel A. Sattler ◽  
Emily K. Mantlo ◽  
Timothy Wanninger ◽  
John T. Manning ◽  
...  
Keyword(s):  
Disease Burden ◽  
Vero Cells ◽  
The United States ◽  
The Novel ◽  
Infectious Titer ◽  
Adenosine Analogue ◽  
Pre Treatment ◽  
Novel Coronavirus ◽  
Dose Dependent

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the novel coronavirus responsible for the ongoing COVID-19 pandemic, which has resulted in over 2.5 million confirmed cases and 170,000 deaths worldwide as of late April 2020. The pandemic currently presents major public health and economic burdens worldwide. No vaccines or therapeutics have been approved for use to treat COVID-19 cases in the United States despite the growing disease burden, thus creating an urgent need for effective treatments. The adenosine analogue remdesivir (REM) has recently been investigated as a potential treatment option, and has shown some activity in limiting SARS-CoV-2 replication. We previously reported that the IMPDH inhibitor merimepodib (MMPD) provides a dose-dependent suppression of SARS-CoV-2 replication in vitro. Here, we report that a 4-hour pre-treatment of Vero cells with 2.5µM MMPD reduces the infectious titer of SARS-CoV-2 more effectively than REM at the same concentration. Additionally, pre-treatment of Vero cells with both REM and MMPD in combination reduces the infectious titer of SARS-CoV-2 to values below the detectable limit of our TCID50 assay. This result was achieved with concentrations as small as 1.25 µM MMPD and 2.5 µM REM. At concentrations of each agent as low as 0.31 µM, significant reduction of viral production occurred. This study provides evidence that REM and MMPD administered in combination might be an effective treatment for COVID-19 cases.

scholarly journals Endangering the Endangered: Impact of fake Covid-19 Social Media Communications in Zimbabwe

2021 ◽  
Author(s):  
Isaac Mhute ◽  
Hugh Mangeya ◽  
Ernest Jakaza
Keyword(s):  
Social Media ◽  
Negative Impact ◽  
The Novel ◽  
Human Species ◽  
The People ◽  
Media Communications ◽  
The Government ◽  
Novel Coronavirus ◽  
The Impact ◽  
Great Danger

The human species is in great danger of extinction due to the novel coronavirus that was first detected in China around December 2019. By March 2021, the world had witnessed over 116million cases, of which 36,223 are Zimbabwean. The disease that the coronavirus stimulates is quite fatal and has seen 2.57million lives succumbing to it, of which 1483 are Zimbabwean, by the same date. No cure has been discovered for it yet, though scientific researchers have already discovered several vaccines with varying efficacies. Employing a socio-pragmatic approach, the chapter explores the impact of fake covid-19 social media communications on efforts to minimize infections and fatalities in Zimbabwe, an already endangered country. It accomplishes this by qualitatively analyzing purposively sampled fake communications in circulation on social media as well as some of the utterances and behaviors people make in response to them. The chapter demonstrates the negative impact of the communications on international mitigating efforts and emphasizes the need for the government, media practitioners and social workers to always be watchful for such misleading communications and in every case to quickly counter their impact by availing correct information to the people.

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