scholarly journals Prenatal Exposure to Unconventional Oil and Gas Operation Chemical Mixtures Altered Mammary Gland Development in Adult Female Mice

Endocrinology ◽  
2018 ◽  
Vol 159 (3) ◽  
pp. 1277-1289 ◽  
Author(s):  
Sarah A Sapouckey ◽  
Christopher D Kassotis ◽  
Susan C Nagel ◽  
Laura N Vandenberg
Keyword(s):  
Mammary Gland ◽  
Prenatal Exposure ◽  
Adult Female ◽  
Mammary Gland Development ◽  
Oil And Gas ◽  
Chemical Mixtures ◽  
Female Mice ◽  
Unconventional Oil ◽  
Unconventional Oil And Gas ◽  
Gland Development

Melatonin inhibits mammary gland development in female mice

1992 ◽  
Vol 13 (1) ◽  
pp. 13-19 ◽  
Author(s):  
M.D. Mediavilla ◽  
M. Martín ◽  
E.J. Sánchez-Barceló
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Development ◽  
Female Mice ◽  
Gland Development

scholarly journals Hydrogen sulfide is a regulator of mammary gland development in prepubescent female mice

2020 ◽  
Author(s):  
Jing Zhang ◽  
Jiayi Ye ◽  
Cong Yuan ◽  
Qin Fu ◽  
Fenglin Zhang ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Mammary Gland ◽  
Mammary Gland Development ◽  
Female Mice ◽  
Gland Development

scholarly journals Adverse Reproductive and Developmental Health Outcomes Following Prenatal Exposure to a Hydraulic Fracturing Chemical Mixture in Female C57Bl/6 Mice

Endocrinology ◽  
2016 ◽  
Vol 157 (9) ◽  
pp. 3469-3481 ◽  
Author(s):  
Christopher D. Kassotis ◽  
John J. Bromfield ◽  
Kara C. Klemp ◽  
Chun-Xia Meng ◽  
Andrew Wolfe ◽  
...  
Keyword(s):  
Drinking Water ◽  
Hydraulic Fracturing ◽  
Health Outcomes ◽  
Prenatal Exposure ◽  
Oil And Gas ◽  
Adverse Outcomes ◽  
Pituitary Hormone ◽  
Unconventional Oil ◽  
Gene Assay ◽  
Unconventional Oil And Gas

Unconventional oil and gas operations using hydraulic fracturing can contaminate surface and groundwater with endocrine-disrupting chemicals. We have previously shown that 23 of 24 commonly used hydraulic fracturing chemicals can activate or inhibit the estrogen, androgen, glucocorticoid, progesterone, and/or thyroid receptors in a human endometrial cancer cell reporter gene assay and that mixtures can behave synergistically, additively, or antagonistically on these receptors. In the current study, pregnant female C57Bl/6 dams were exposed to a mixture of 23 commonly used unconventional oil and gas chemicals at approximately 3, 30, 300, and 3000 μg/kg·d, flutamide at 50 mg/kg·d, or a 0.2% ethanol control vehicle via their drinking water from gestational day 11 through birth. This prenatal exposure to oil and gas operation chemicals suppressed pituitary hormone concentrations across experimental groups (prolactin, LH, FSH, and others), increased body weights, altered uterine and ovary weights, increased heart weights and collagen deposition, disrupted folliculogenesis, and other adverse health effects. This work suggests potential adverse developmental and reproductive health outcomes in humans and animals exposed to these oil and gas operation chemicals, with adverse outcomes observed even in the lowest dose group tested, equivalent to concentrations reported in drinking water sources. These endpoints suggest potential impacts on fertility, as previously observed in the male siblings, which require careful assessment in future studies.

Periconceptional, gestational, and lactational exposure to unconventional oil and gas chemical mixture alters energy expenditure in adult female mice

2018 ◽  
Author(s):  
◽  
Victoria Danielle Balise
Keyword(s):  
Energy Expenditure ◽  
Oil And Gas ◽  
Light Cycle ◽  
High Fat ◽  
Pressurized Water ◽  
Developmental Exposure ◽  
Female Mice ◽  
High Sugar ◽  
Unconventional Oil ◽  
Unconventional Oil And Gas

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Unconventional oil and gas (UOG) processes involves injection of pressurized water, chemicals, and suspended solids thousands of feet under the surface to release natural gas and oil. Previously our lab has shown antagonist activity in 23 of 24 UOG chemicals tested for estrogen, androgen, progesterone, glucocorticoid, and/or thyroid receptors. We hypothesized that developmental exposure to a mixture of 23 chemicals used in UOG processes would program the fetus and alter metabolism in adulthood and would be exacerbated by age and a high fat high sugar diet. A lab made mixture of 23 UOG chemicals at equimass concentrations was administered via drinking water at a range of dosages to pregnant and lactating mice from gestation day 1 to postnatal day 21 and offspring were analyzed at 7 months of age and again at 12 months of age on a high fat and high sugar diet. Developmental exposure was associated with altered pre-pubertal body weight and adult energy expenditure in 7-month-old female mice, particularly in the dark cycle when mice are more active. At 12 months of age on a high fat diet there was increased spontaneous activity (beam breaks) and total meters travelled during the light cycle, when mice are less active. Mice also had increased exploratory activity in the elevated plus maze. More active treatment groups also had an increase in energy expenditure, and a decrease in fat mass. These results suggest the potential for developmental health outcomes related to activity in humans and animals exposed to UOG chemicals.

scholarly journals Mammary Gland Development as a Sensitive End Point after Acute Prenatal Exposure to an Atrazine Metabolite Mixture in Female Long-Evans Rats

2007 ◽  
Vol 115 (4) ◽  
pp. 541-547 ◽  
Author(s):  
Rolondo R. Enoch ◽  
Jason P. Stanko ◽  
Sara N. Greiner ◽  
Geri L. Youngblood ◽  
Jennifer L. Rayner ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Prenatal Exposure ◽  
Mammary Gland Development ◽  
End Point ◽  
Long Evans ◽  
Gland Development
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