scholarly journals Glucocorticoid Signaling in Health and Disease: Insights From Tissue-Specific GR Knockout Mice

Endocrinology ◽  
2017 ◽  
Vol 159 (1) ◽  
pp. 46-64 ◽  
Author(s):  
Shannon Whirledge ◽  
Donald B DeFranco
Keyword(s):  
Knockout Mice ◽  
Tissue Specific ◽  
Glucocorticoid Signaling ◽  
Health And Disease

Tissue-Specific Transgenic and Knockout Mice

Ion Channels ◽  
2006 ◽  
pp. 185-205 ◽  
Author(s):  
Gildas Loussouarn ◽  
Isabelle Baró ◽  
Denis Escande
Keyword(s):  
Knockout Mice ◽  
Tissue Specific

scholarly journals The Glucocorticoid Receptor in Cardiovascular Health and Disease

Cells ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 1227 ◽  
Author(s):  
Liu ◽  
Zhang ◽  
Knight ◽  
Goodwin
Keyword(s):  
Glucocorticoid Receptor ◽  
Cardiovascular System ◽  
Gene Networks ◽  
Cardiovascular Health ◽  
Critical Role ◽  
Glucocorticoid Signaling ◽  
Health And Disease ◽  
Nuclear Receptor Family

The glucocorticoid receptor is a member of the nuclear receptor family that controls many distinct gene networks, governing various aspects of development, metabolism, inflammation, and the stress response, as well as other key biological processes in the cardiovascular system. Recently, research in both animal models and humans has begun to unravel the profound complexity of glucocorticoid signaling and convincingly demonstrates that the glucocorticoid receptor has direct effects on the heart and vessels in vivo and in vitro. This research has contributed directly to improving therapeutic strategies in human disease. The glucocorticoid receptor is activated either by the endogenous steroid hormone cortisol or by exogenous glucocorticoids and acts within the cardiovascular system via both genomic and non-genomic pathways. Polymorphisms of the glucocorticoid receptor are also reported to influence the progress and prognosis of cardiovascular disease. In this review, we provide an update on glucocorticoid signaling and highlight the critical role of this signaling in both physiological and pathological conditions of the cardiovascular system. With increasing in-depth understanding of glucocorticoid signaling, the future is promising for the development of targeted glucocorticoid treatments and improved clinical outcomes.

scholarly journals Histamine deficiency induces tissue-specific down-regulation of histamine H2 receptor expression in histidine decarboxylase knockout mice

FEBS Letters ◽  
2001 ◽  
Vol 508 (2) ◽  
pp. 245-248 ◽  
Author(s):  
Carlos P. Fitzsimons ◽  
Eszter Lazar-Molnar ◽  
Zsuzsa Tomoskozi ◽  
Edit Buzás ◽  
Elena S. Rivera ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Histidine Decarboxylase ◽  
Receptor Expression ◽  
Down Regulation ◽  
Histamine H2 Receptor ◽  
Tissue Specific ◽  
H2 Receptor

scholarly journals Tissue-specific conditional PKCε knockout mice: a model to precisely reveal PKCε functional role in initiation, promotion and progression of cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (22) ◽  
pp. 33069-33080
Author(s):  
Bilal Bin Hafeez ◽  
Louise Meske ◽  
Ashok Singh ◽  
Anupama Singh ◽  
Weixiong Zhong ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Functional Role ◽  
Tissue Specific

Orphan Nuclear Receptors in Reproduction: Lessons from Tissue-Specific Knockout Mice.

2011 ◽  
Vol 85 (Suppl_1) ◽  
pp. 161-161
Author(s):  
Cong Zhang ◽  
Kalyne Bertolin ◽  
Raj Duggavathi ◽  
Bruce D. Murphy
Keyword(s):  
Nuclear Receptors ◽  
Knockout Mice ◽  
Orphan Nuclear Receptors ◽  
Tissue Specific
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