scholarly journals In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice

Endocrinology ◽  
2017 ◽  
Vol 158 (9) ◽  
pp. 2860-2872 ◽  
Author(s):  
Yoshinori Seki ◽  
Masako Suzuki ◽  
Xingyi Guo ◽  
Alan Scott Glenn ◽  
Patricia M Vuguin ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
High Fat Diet ◽  
In Utero ◽  
In Utero Exposure ◽  
Male Mice ◽  
High Fat ◽  
Gene Dysregulation

64: In utero exposure to a maternal high fat diet Alters the epigenetic histone code in a murine model

2014 ◽  
Vol 210 (1) ◽  
pp. S42-S43
Author(s):  
Melissa Suter ◽  
Jun Ma ◽  
Patricia Vuguin ◽  
Kirsten Hartil ◽  
Ariana Fiallo ◽  
...  
Keyword(s):  
Murine Model ◽  
High Fat Diet ◽  
In Utero ◽  
Histone Code ◽  
In Utero Exposure ◽  
High Fat

53: In utero exposure to a maternal high fat diet alters the epigenetic histone code in a murine model

2009 ◽  
Vol 201 (6) ◽  
pp. S31
Author(s):  
Melissa Suter ◽  
Kirsten Hartil ◽  
Patricia Vuguin ◽  
Ariana Fiallo ◽  
Maureen Charron ◽  
...  
Keyword(s):  
Murine Model ◽  
High Fat Diet ◽  
In Utero ◽  
Histone Code ◽  
In Utero Exposure ◽  
High Fat

scholarly journals The Effects of High-Fat Diet Exposure In Utero on the Obesogenic and Diabetogenic Traits Through Epigenetic Changes in Adiponectin and Leptin Gene Expression for Multiple Generations in Female Mice

Endocrinology ◽  
2015 ◽  
Vol 156 (7) ◽  
pp. 2482-2491 ◽  
Author(s):  
Hisashi Masuyama ◽  
Takashi Mitsui ◽  
Etsuko Nobumoto ◽  
Yuji Hiramatsu
Keyword(s):  
Metabolic Syndrome ◽  
Fat Mass ◽  
High Fat Diet ◽  
Mass Gain ◽  
Female Offspring ◽  
In Utero ◽  
Normal Diet ◽  
Epigenetic Changes ◽  
High Fat ◽  
Multiple Generations

Recent studies demonstrate that epigenetic changes under malnutrition in utero might play important roles in transgenerational links with metabolic diseases. We have previously shown that exposure to a high-fat diet (HFD) in utero may cause a metabolic syndrome-like phenomenon through epigenetic modifications of Adiponectin and Leptin genes. Because an association of obesity between mother and offspring endured in multiple generations, we examined whether HFD exposure in utero might affect the metabolic status of female offspring through multigenerational epigenetic changes of Adiponectin and Leptin genes and whether a normal diet in utero for multiple generations might abolish such epigenetic changes after exposure to a HFD in utero using ICR mice. We observed that the effect of maternal HFD on offspring over multiple generations in metabolic syndrome-like phenomenon such as weight and fat mass gain, glucose intolerance, hypertriglyceridemia, abnormal adiponectin and leptin levels, and hypertension, were accumulated with expression and epigenetic changes in Adiponectin and Leptin genes. A normal diet in utero in the subsequent generations after HFD exposure in utero diminished, and a normal diet in utero for 3 generations completely abolished, the effect of HFD in utero on weight and fat mass gain, insulin resistance, serum triglyceride, adiponectin, and leptin levels, with epigenetic changes of Adiponectin and Leptin genes. Exposure to a HFD in utero might affect glucose and lipid metabolism of female offspring through epigenetic modifications to Adiponectin and Leptin genes for multiple generations. Obesogenic and diabetogenic traits were abolished after a maternal normal diet for 3 generations.

scholarly journals Effects of a High-Fat Diet Exposure in Utero on the Metabolic Syndrome-Like Phenomenon in Mouse Offspring through Epigenetic Changes in Adipocytokine Gene Expression

Endocrinology ◽  
2012 ◽  
Vol 153 (6) ◽  
pp. 2823-2830 ◽  
Author(s):  
Hisashi Masuyama ◽  
Yuji Hiramatsu
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
High Fat Diet ◽  
Control Diet ◽  
Caloric Intake ◽  
In Utero ◽  
Shared Environment ◽  
Epigenetic Changes ◽  
High Fat ◽  
The Metabolic Syndrome

The links between obesity in parents and their offspring and the role of genes and a shared environment are not completely understood. Adipocytokines such as leptin and adiponectin play important roles in glucose and lipid metabolism. Therefore, we examined whether the offspring from dams exposed to a high-fat diet during pregnancy (OH mice) exhibited hypertension, insulin resistance, and hyperlipidemia along with epigenetic changes in the expression of adipocytokine genes. OH mice were significantly heavier than the offspring of dams exposed to a control diet during pregnancy (OC mice) from 14 wk of age after an increased caloric intake from 8 wk. OH mice exhibited higher blood pressure and worse glucose tolerance than the OC mice at 24 wk. Total triglyceride and leptin levels were significantly higher and the adiponectin level was significantly lower in OH compared with OC mice at 12 wk of age. This was associated with changes in leptin and adiponectin expression in white adipose tissue. There were lower acetylation and higher methylation levels of histone H3 at lysine 9 of the promoter of adiponectin in adipose tissues of OH mice at 2 wk of age as well as at 12 and 24 wk of age compared with OC mice. In contrast, methylation of histone 4 at lysine 20 in the leptin promoter was significantly higher in OH compared with OC mice. Thus, exposure to a high-fat diet in utero might cause a metabolic syndrome-like phenomenon through epigenetic modifications of adipocytokine, adiponectin, and leptin gene expression.

In Utero Exposure to Second‐Hand Cigarette Smoke Promotes Epigenetically‐Mediated Cardiac Dysfunction in High‐Fat Fed Male Mice

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
martin ronis ◽  
Huijing Xia ◽  
samya lima rodrigues ◽  
Eli El Haji ◽  
Alexandra Noel ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Cardiac Dysfunction ◽  
In Utero ◽  
In Utero Exposure ◽  
Male Mice ◽  
High Fat

scholarly journals Maternal Substrate Utilization Programs the Development of the Metabolic Syndrome in Male Mice Exposed to High Fat In Utero

2009 ◽  
Vol 66 (4) ◽  
pp. 368-373 ◽  
Author(s):  
Kirsten Hartil ◽  
Patricia M Vuguin ◽  
Michael Kruse ◽  
Esther Schmuel ◽  
Ariana Fiallo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Substrate Utilization ◽  
In Utero ◽  
Male Mice ◽  
High Fat ◽  
The Metabolic Syndrome

scholarly journals In utero exposure to a maternal high-fat diet alters the epigenetic histone code in a murine model

2014 ◽  
Vol 210 (5) ◽  
pp. 463.e1-463.e11 ◽  
Author(s):  
Melissa A. Suter ◽  
Jun Ma ◽  
Patricia M. Vuguin ◽  
Kirsten Hartil ◽  
Ariana Fiallo ◽  
...  
Keyword(s):  
Murine Model ◽  
High Fat Diet ◽  
In Utero ◽  
Histone Code ◽  
In Utero Exposure ◽  
High Fat

scholarly journals High Fat Diet and In Utero Exposure to Maternal Obesity Disrupts Circadian Rhythm and Leads to Metabolic Programming of Liver in Rat Offspring

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e84209 ◽  
Author(s):  
Sarah J. Borengasser ◽  
Ping Kang ◽  
Jennifer Faske ◽  
Horacio Gomez-Acevedo ◽  
Michael L. Blackburn ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
High Fat Diet ◽  
Maternal Obesity ◽  
In Utero ◽  
Metabolic Programming ◽  
In Utero Exposure ◽  
High Fat ◽  
Rat Offspring
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