scholarly journals Beam Me In: Thyroid Hormone Analog Targets Alternative Transporter in Mouse Model of X-Linked Adrenoleukodystrophy

Endocrinology ◽  
2017 ◽  
Vol 158 (5) ◽  
pp. 1116-1119 ◽  
Author(s):  
Anna Milanesi ◽  
Gregory A. Brent
Keyword(s):  
Thyroid Hormone ◽  
Mouse Model ◽  
Hormone Analog

Pilot Studies on the Use of 3,5-Diiodothyropropionic Acid, a Thyroid Hormone Analog, in the Treatment of Congestive Heart Failure

Cardiology ◽  
2002 ◽  
Vol 97 (4) ◽  
pp. 218-225 ◽  
Author(s):  
Eugene Morkin ◽  
Gregory Pennock ◽  
Peter H. Spooner ◽  
Joseph J. Bahl ◽  
Katherine Underhill Fox ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Thyroid Hormone ◽  
Pilot Studies ◽  
Hormone Analog

DITPA, A Thyroid Hormone Analog, Reduces Infarct Size and Attenuates the Inflammatory Response Following Myocardial Ischemia

2011 ◽  
Vol 171 (2) ◽  
pp. 379-385 ◽  
Author(s):  
Abdelrahman A. Abohashem-Aly ◽  
Xianzhong Meng ◽  
Jilin Li ◽  
Miral R. Sadaria ◽  
Lihua Ao ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Myocardial Ischemia ◽  
Inflammatory Response ◽  
Infarct Size ◽  
Hormone Analog

scholarly journals Thyroid Hormone Receptor Alpha Mutations Lead to Epithelial Defects in the Adult Intestine in a Mouse Model of Resistance to Thyroid Hormone

Thyroid ◽  
2019 ◽  
Vol 29 (3) ◽  
pp. 439-448 ◽  
Author(s):  
Lingyu Bao ◽  
Julia Roediger ◽  
Sunmi Park ◽  
Liezhen Fu ◽  
Bingyin Shi ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Mouse Model ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Resistance To Thyroid Hormone ◽  
Receptor Alpha

scholarly journals Thyroid Hormone Metabolism Defects in a Mouse Model of SBP2 Deficiency

Endocrinology ◽  
2017 ◽  
Vol 158 (12) ◽  
pp. 4317-4330 ◽  
Author(s):  
Jiao Fu ◽  
Haruki Fujisawa ◽  
Benjamin Follman ◽  
Xiao-Hui Liao ◽  
Alexandra M Dumitrescu
Keyword(s):  
Thyroid Hormone ◽  
Mouse Model ◽  
Hormone Metabolism ◽  
Thyroid Hormone Metabolism

The thyroid hormone analog DITPA restoresI to in rats after myocardial infarction

2000 ◽  
Vol 278 (4) ◽  
pp. H1105-H1116 ◽  
Author(s):  
Alan D. Wickenden ◽  
Roger Kaprielian ◽  
Xiao-Mang You ◽  
Peter H. Backx
Keyword(s):  
Myocardial Infarction ◽  
Thyroid Hormone ◽  
Action Potential ◽  
Ventricular Myocytes ◽  
Monophasic Action Potential ◽  
Mrna Levels ◽  
Hormone Analog ◽  
Life Threatening ◽  
The Right

Previous studies have established that reductions in repolarizing currents occur in heart disease and can contribute to life-threatening arrhythmias in myocardium. In this study, we investigated whether the thyroid hormone analog 3,5-diiodothyropropionic acid (DITPA) could restore repolarizing transient outward K+ current ( I to) density and gene expression in rat myocardium after myocardial infarction (MI). Our findings show that I to density was reduced after MI (14.0 ± 1.0 vs. 10.2 ± 0.9 pA/pF, sham vs. post-MI at +40 mV). mRNA levels of Kv4.2 and Kv4.3genes were decreased but Kv1.4 mRNA levels were increased post-MI. Corresponding changes in Kv4.2 and Kv1.4 protein were also observed. Chronic treatment of post-MI rats with 10 mg/kg DITPA restored I to density (to 15.2 ± 1.1 pA/pF at +40 mV) as well as Kv4.2 and Kv1.4 expression to levels observed in sham-operated controls. Other membrane currents (Na+, L-type Ca2+, sustained, and inward rectifier K+ currents) were unaffected by DITPA treatment. Associated with the changes in I toexpression, action potential durations (current-clamp recordings in isolated single right ventricular myocytes and monophasic action potential recordings from the right free wall in situ) were prolonged after MI and restored with DITPA treatment. Our results demonstrate that DITPA restores I to density in the setting of MI, which may be useful in preventing complications associated with I to downregulation.

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