scholarly journals Prepubertal Di-n-Butyl Phthalate Exposure Alters Sertoli and Leydig Cell Function and Lowers Bone Density in Adult Male Mice

Endocrinology ◽  
2016 ◽  
Vol 157 (7) ◽  
pp. 2595-2603 ◽  
Author(s):  
Amanda Bielanowicz ◽  
Rachelle W. Johnson ◽  
Hoey Goh ◽  
Sarah C. Moody ◽  
Ingrid J. Poulton ◽  
...  
Keyword(s):  
Bone Density ◽  
Adult Male ◽  
Leydig Cell ◽  
Cell Function ◽  
Male Mice ◽  
Phthalate Exposure ◽  
Butyl Phthalate ◽  
Leydig Cell Function

scholarly journals Effects of CDB-4022 on Leydig Cell Function in Adult Male Rats1

2007 ◽  
Vol 77 (6) ◽  
pp. 1017-1026 ◽  
Author(s):  
Yu-Chyu Chen ◽  
Renate K. Cochrum ◽  
Michael T. Tseng ◽  
Dushan T. Ghooray ◽  
Joseph P. Moore ◽  
...  
Keyword(s):  
Adult Male ◽  
Leydig Cell ◽  
Cell Function ◽  
Leydig Cell Function

Prenatal phthalate exposure is associated with human fetal Leydig cell function but not with cryptorchidism and hypospadias

2013 ◽  
Vol 2013 (1) ◽  
pp. 5803
Author(s):  
Morten Søndergaard Jensen ◽  
Bent Nørgaard-Pedersen ◽  
Bo A.G. Jönsson ◽  
Jens Peter Bonde ◽  
David M. Hougaard ◽  
...  
Keyword(s):  
Leydig Cell ◽  
Cell Function ◽  
Phthalate Exposure ◽  
Leydig Cell Function

DISORDERS OF LEYDIG CELL FUNCTION IN PRIMARY ADRENAL INSUFFICIENY

1974 ◽  
Vol 77 (1_Suppl) ◽  
pp. S61
Author(s):  
R. Mies ◽  
D. Heesen ◽  
W. Winkelmann
Keyword(s):  
Leydig Cell ◽  
Cell Function ◽  
Leydig Cell Function

FSH regulates cultured Leydig cell function via Sertoli cell proteins: An in vitro study

1985 ◽  
Vol 132 (2) ◽  
pp. 729-734 ◽  
Author(s):  
M. Benahmed ◽  
C. Grenot ◽  
E. Tabone ◽  
P. Sanchez ◽  
A.M. Morera
Keyword(s):  
Sertoli Cell ◽  
Leydig Cell ◽  
Cell Function ◽  
In Vitro Study ◽  
Vitro Study ◽  
Leydig Cell Function

Impaired Testicular Function in Patients With Carcinoma-In-Situ of the Testis

1999 ◽  
Vol 17 (1) ◽  
pp. 173-173 ◽  
Author(s):  
Peter Meidahl Petersen ◽  
Aleksander Giwercman ◽  
Steen W. Hansen ◽  
Jørgen G. Berthelsen ◽  
Gedske Daugaard ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Germ Cell ◽  
Leydig Cell ◽  
Carcinoma In Situ ◽  
Cell Function ◽  
Semen Quality ◽  
Sperm Concentration ◽  
Testicular Dysfunction ◽  
Leydig Cell Function

PURPOSE: To elucidate the biologic association between germ cell neoplasia and testicular dysfunction, through investigation of Leydig cell function and semen quality in men with carcinoma-in-situ (CIS) of the testis. PATIENTS AND METHODS: We examined two groups of men, unilaterally orchidectomized for testicular cancer. Biopsy of the contralateral testis had showed CIS in a group of 24 patients and no evidence of CIS in the other group of 30 patients. Semen quality and serum levels of testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were compared in these two groups of men after orchidectomy but before further treatment for testicular cancer. RESULTS: Significantly higher LH levels (median, 8.1 IU/L v 4.8 IU/L; P < .001) and generally lower testosterone levels (median, 12.5 nmol/L v 15.5 nmol/L; P = .13) were found in the CIS group. The proportion of patients with Leydig cell dysfunction was higher in the group of patients with CIS (11 of 24) than in the group of patients without (two of 30) (P = .01). Sperm concentration and total sperm count were significantly lower (P < .001) in patients with CIS (median, 0.03 × 106/mL and 0.10 × 106, respectively) than in patients without (median, 9.1 × 106/mL and 32 × 106, respectively), whereas the levels of FSH were significantly higher (P < .001) in the former group of men (median, 19.6 IU/L v 9.0 IU/L). CONCLUSION: Not only spermatogenesis but also Leydig cell function is impaired in testes with CIS. This impairment could be due to common factors in the pathogenesis of germ cell neoplasm and testicular dysfunction. Alternatively, CIS cells may have a negative impact on Leydig cell function.

scholarly journals Leydig Cell Function in Long-term Testosterone-immunized Rats

1983 ◽  
Vol 4 (1) ◽  
pp. 95-103 ◽  
Author(s):  
RICHARD M. SHARPE ◽  
HAMISH M. FRASER
Keyword(s):  
Leydig Cell ◽  
Cell Function ◽  
Leydig Cell Function
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