scholarly journals Small-Molecule Ghrelin Receptor Antagonists Improve Glucose Tolerance, Suppress Appetite, and Promote Weight Loss

Endocrinology ◽  
2007 ◽  
Vol 148 (11) ◽  
pp. 5175-5185 ◽  
Author(s):  
William P. Esler ◽  
Joachim Rudolph ◽  
Thomas H. Claus ◽  
Weifeng Tang ◽  
Nicole Barucci ◽  
...  
Keyword(s):  
Weight Loss ◽  
Glucose Tolerance ◽  
Small Molecule ◽  
Receptor Antagonists ◽  
Promote Weight Loss ◽  
Ghrelin Receptor ◽  
Improve Glucose Tolerance

A randomized controlled trial of matching of deposit contracts to promote weight loss

2013 ◽  
Author(s):  
Jeffrey T. Kullgren ◽  
Andrea B. Troxel ◽  
George Loewenstein ◽  
Laurie A. Norton ◽  
Dana Gatto ◽  
...  
Keyword(s):  
Weight Loss ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Promote Weight Loss ◽  
Randomized Controlled ◽  
Deposit Contracts

A telehealth intervention to promote weight loss and physical activity in overweight primary care patients

Healthcare ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 100509
Author(s):  
Ian Hurst ◽  
Paul J. Bixenstine ◽  
Carlos Casillas ◽  
Anna Rasmussen ◽  
Sondra Grossman ◽  
...  
Keyword(s):  
Physical Activity ◽  
Primary Care ◽  
Weight Loss ◽  
Promote Weight Loss ◽  
Telehealth Intervention ◽  
Primary Care Patients

scholarly journals Oleoylethanolamide modulates glucagon-like peptide-1 receptor agonist signaling and enhances exendin-4-mediated weight loss in obese mice

2018 ◽  
Vol 315 (4) ◽  
pp. R595-R608 ◽  
Author(s):  
Jacob D. Brown ◽  
Danielle McAnally ◽  
Jennifer E. Ayala ◽  
Melissa A. Burmeister ◽  
Camilo Morfa ◽  
...  
Keyword(s):  
Weight Loss ◽  
Energy Expenditure ◽  
Receptor Agonist ◽  
Day Treatment ◽  
Mtor Pathway ◽  
Obese Mice ◽  
Promote Weight Loss ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Long Acting

Long-acting glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonists (GLP-1RA), such as exendin-4 (Ex4), promote weight loss. On the basis of a newly discovered interaction between GLP-1 and oleoylethanolamide (OEA), we tested whether OEA enhances GLP-1RA-mediated anorectic signaling and weight loss. We analyzed the effect of GLP-1+OEA and Ex4+OEA on canonical GLP-1R signaling and other proteins/pathways that contribute to the hypophagic action of GLP-1RA (AMPK, Akt, mTOR, and glycolysis). We demonstrate that OEA enhances canonical GLP-1R signaling when combined with GLP-1 but not with Ex4. GLP-1 and Ex4 promote phosphorylation of mTOR pathway components, but OEA does not enhance this effect. OEA synergistically enhanced GLP-1- and Ex4-stimulated glycolysis but did not augment the hypophagic action of GLP-1 or Ex4 in lean or diet-induced obese (DIO) mice. However, the combination of Ex4+OEA promoted greater weight loss in DIO mice than Ex4 or OEA alone during a 7-day treatment. This was due in part to transient hypophagia and increased energy expenditure, phenotypes also observed in Ex4-treated DIO mice. Thus, OEA augments specific GLP-1RA-stimulated signaling but appears to work in parallel with Ex4 to promote weight loss in DIO mice. Elucidating cooperative mechanisms underlying Ex4+OEA-mediated weight loss could, therefore, be leveraged toward more effective obesity therapies.

Scam Alert 2022 !! Best Health Keto UK Reviews – Negative Side Effects or Safe Diet Pills? Is £39.76 Worthy for “Best Health Keto United Kingdom” Customers? Read This Before Buy v1

2022 ◽  
Author(s):  
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Keyword(s):  
Weight Loss ◽  
United Kingdom ◽  
Side Effects ◽  
Fat Cells ◽  
Promote Weight Loss ◽  
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