scholarly journals Expression and Externalization of Annexin 1 in the Adrenal Gland: Structure and Function of the Adrenal Gland in Annexin 1-Null Mutant Mice

Endocrinology ◽  
2007 ◽  
Vol 148 (3) ◽  
pp. 1030-1038 ◽  
Author(s):  
Evelyn Davies ◽  
Selma Omer ◽  
Julia C. Buckingham ◽  
John F. Morris ◽  
Helen C. Christian
Keyword(s):  
Adrenal Gland ◽  
Structure And Function ◽  
Mutant Mice ◽  
Null Mutant ◽  
Annexin 1 ◽  
Null Mutant Mice ◽  
And Function

scholarly journals Development, Maintenance, and Function of the Adrenal Gland in Early Postnatal Proopiomelanocortin-Null Mutant Mice

Endocrinology ◽  
2005 ◽  
Vol 146 (6) ◽  
pp. 2555-2562 ◽  
Author(s):  
Jason Karpac ◽  
Dirk Ostwald ◽  
Stephanie Bui ◽  
Peggy Hunnewell ◽  
Malini Shankar ◽  
...  
Keyword(s):  
Adrenal Glands ◽  
Mutant Mice ◽  
Null Mutant ◽  
Wild Type ◽  
Normal Morphology ◽  
Adrenal Hormones ◽  
Adrenal Cells ◽  
Mouse Mutants ◽  
Null Mutant Mice ◽  
And Function

Abstract Adult mouse mutants homozygous for an engineered proopiomelanocortin (POMC)-null allele lack macroscopically distinct adrenal glands and circulating adrenal hormones. To understand the basis for this adrenal defect, we compared the development of adrenal primordia in POMC-null mice and littermate controls. POMC-null mutant mice are born with adrenal glands that are morphologically indistinguishable from those of their wild-type littermates. However, in mutants adrenal cells fail to proliferate postnatally and adrenals atrophy until they have disappeared macroscopically in the adult. While present, mutant adrenals are differentiated as evidenced by the presence of enzymes for the final steps in the synthesis of corticosterone, aldosterone, and catecholamines. However, in contrast to adrenals of wild-type littermates, adrenals of POMC-null mutants do not produce corticosterone, not even in response to acute stimulation with exogenous ACTH. They do produce aldosterone; however, it is produced at reduced levels correlating with adrenal size. Transplantation of POMC-null mutant adrenals to adrenalectomized wild-type littermates results in adrenals with normal morphology and production of both corticosterone and aldosterone. These findings demonstrate that POMC peptides are not required for prenatal adrenal development and that POMC peptides in addition to ACTH are required for postnatal proliferation and maintenance of adrenal structures capable of producing both glucocorticoids and mineralocorticoids.

scholarly journals Role of RANKL (TNFSF11)-Dependent Osteopetrosis in the Dental Phenotype of Msx2 Null Mutant Mice

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e80054 ◽  
Author(s):  
Beatriz Castaneda ◽  
Yohann Simon ◽  
Didier Ferbus ◽  
Benoit Robert ◽  
Julie Chesneau ◽  
...  
Keyword(s):  
Mutant Mice ◽  
Null Mutant ◽  
Null Mutant Mice

scholarly journals Galanin receptor subtype 2 (GalR2) null mutant mice display an anxiogenic-like phenotype specific to the elevated plus-maze

2007 ◽  
Vol 86 (1) ◽  
pp. 8-20 ◽  
Author(s):  
Kathleen R. Bailey ◽  
Maria N. Pavlova ◽  
Alex D. Rohde ◽  
John G. Hohmann ◽  
Jacqueline N. Crawley
Keyword(s):  
Elevated Plus Maze ◽  
Mutant Mice ◽  
Receptor Subtype ◽  
Null Mutant ◽  
Galanin Receptor ◽  
Plus Maze ◽  
Null Mutant Mice

scholarly journals Bcr/Abl associated leukemogenesis in bcr null mutant mice

Oncogene ◽  
1998 ◽  
Vol 16 (15) ◽  
pp. 2029-2032 ◽  
Author(s):  
Jan Willem Voncken ◽  
Vesa Kaartinen ◽  
John Groffen ◽  
Nora Heisterkamp
Keyword(s):  
Mutant Mice ◽  
Null Mutant ◽  
Null Mutant Mice
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