scholarly journals Developmental Switch from Prolonged Insulin Action to Increased Insulin Sensitivity in Protein Tyrosine Phosphatase 1B-Deficient Hepatocytes

Endocrinology ◽  
2007 ◽  
Vol 148 (2) ◽  
pp. 594-608 ◽  
Author(s):  
Agueda Gonzalez-Rodriguez ◽  
Jill E. Clampit ◽  
Oscar Escribano ◽  
Manuel Benito ◽  
Cristina M. Rondinone ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Protein Tyrosine Phosphatase ◽  
Insulin Action ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Developmental Switch

scholarly journals Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

2000 ◽  
Vol 20 (15) ◽  
pp. 5479-5489 ◽  
Author(s):  
Lori D. Klaman ◽  
Olivier Boss ◽  
Odile D. Peroni ◽  
Jason K. Kim ◽  
Jennifer L. Martino ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Energy Expenditure ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Tissue Specific ◽  
Protein Tyrosine ◽  
Ptp 1B ◽  
Deficient Mice

ABSTRACT Protein-tyrosine phosphatase 1B (PTP-1B) is a major protein-tyrosine phosphatase that has been implicated in the regulation of insulin action, as well as in other signal transduction pathways. To investigate the role of PTP-1B in vivo, we generated homozygotic PTP-1B-null mice by targeted gene disruption. PTP-1B-deficient mice have remarkably low adiposity and are protected from diet-induced obesity. Decreased adiposity is due to a marked reduction in fat cell mass without a decrease in adipocyte number. Leanness in PTP-1B-deficient mice is accompanied by increased basal metabolic rate and total energy expenditure, without marked alteration of uncoupling protein mRNA expression. In addition, insulin-stimulated whole-body glucose disposal is enhanced significantly in PTP-1B-deficient animals, as shown by hyperinsulinemic-euglycemic clamp studies. Remarkably, increased insulin sensitivity in PTP-1B-deficient mice is tissue specific, as insulin-stimulated glucose uptake is elevated in skeletal muscle, whereas adipose tissue is unaffected. Our results identify PTP-1B as a major regulator of energy balance, insulin sensitivity, and body fat stores in vivo.

Small Molecule Peptidomimetics Containing a Novel Phosphotyrosine Bioisostere Inhibit Protein Tyrosine Phosphatase 1B and Augment Insulin Action‡

Biochemistry ◽  
2001 ◽  
Vol 40 (19) ◽  
pp. 5642-5654 ◽  
Author(s):  
John E. Bleasdale ◽  
Derek Ogg ◽  
Barbara J. Palazuk ◽  
Cynthia S. Jacob ◽  
Michael L. Swanson ◽  
...  
Keyword(s):  
Small Molecule ◽  
Protein Tyrosine Phosphatase ◽  
Insulin Action ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine

scholarly journals PROTEIN TYROSINE PHOSPHATASE 1B (PTP1B) IN OBESITY AND TYPE 2 DIABETES

2009 ◽  
Vol 38 (1) ◽  
pp. 2-7 ◽  
Author(s):  
Mirela Delibegovic ◽  
Nimesh Mody
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Sensitivity ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Developed Countries ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
The Developed Countries

Increased incidence in obesity is reaching epidemic proportions and is placing a major burden on the healthcare systems in the developed countries. Obesity is a major risk factor for the development of type 2 diabetes, metabolic syndrome, cardiovascular disease and cancer. Thus, the search for molecules that regulate the development of obesity and its associated pathologies is ongoing. Protein tyrosine phosphatase 1B (PTP1B) has been found to be a major regulator of body fat stores, energy balance, and insulin sensitivity in vivo. Increased expression of PTP1B is associated with insulin resistance in rodents and humans and deletion of PTP1B leads to leanness and insulin sensitivity in rodents, suggesting that PTP1B may be a very attractive molecular target for anti-obesity, anti-diabetic agents.

scholarly journals Increasing Peripheral Insulin Sensitivity by Protein Tyrosine Phosphatase 1B Deletion Improves Control of Blood Pressure in Obesity

Hypertension ◽  
2012 ◽  
Vol 60 (5) ◽  
pp. 1273-1279 ◽  
Author(s):  
Eric J. Belin de Chantemèle ◽  
Mohammed Irfan Ali ◽  
James D. Mintz ◽  
William E. Rainey ◽  
Michel L. Tremblay ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Insulin Sensitivity ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Peripheral Insulin Sensitivity
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