scholarly journals Peroxisome Proliferator-Activated Receptor γ-Dependent Activation of p21 in Panc-28 Pancreatic Cancer Cells Involves Sp1 and Sp4 Proteins

Endocrinology ◽  
2004 ◽  
Vol 145 (12) ◽  
pp. 5774-5785 ◽  
Author(s):  
Jun Hong ◽  
Ismael Samudio ◽  
Shengxi Liu ◽  
Maen Abdelrahim ◽  
Stephen Safe
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Pancreatic Cancer Cells

Peroxisome proliferator-activated receptor γ reduces the growth rate of pancreatic cancer cells through the reduction of cyclin D1

Life Sciences ◽  
2002 ◽  
Vol 70 (13) ◽  
pp. 1565-1575 ◽  
Author(s):  
Miyuki Toyota ◽  
Yoshiji Miyazaki ◽  
Shinji Kitamura ◽  
Yutaka Nagasawa ◽  
Tatsuya Kiyohara ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Growth Rate ◽  
Cyclin D1 ◽  
Cancer Cells ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Pancreatic Cancer Cells

scholarly journals Role of Peroxisome Proliferator-Activated Receptorβ/δand B-Cell Lymphoma-6 in Regulation of Genes Involved in Metastasis and Migration in Pancreatic Cancer Cells

PPAR Research ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Jeffrey D. Coleman ◽  
Jerry T. Thompson ◽  
Russell W. Smith ◽  
Bogdan Prokopczyk ◽  
John P. Vanden Heuvel
Keyword(s):  
Pancreatic Cancer ◽  
Basement Membrane ◽  
Cancer Cells ◽  
Target Genes ◽  
B Cell Lymphoma ◽  
Human Pancreatic Cancer ◽  
Cancer Tissue ◽  
Peroxisome Proliferator ◽  
Matrix Remodeling ◽  
Pancreatic Cancer Cells

PPARβ/δis a ligand-activated transcription factor that regulates various cellular functions via induction of target genes directly or in concert with its associated transcriptional repressor,BCL-6. Matrix remodeling proteinases are frequently over-expressed in pancreatic cancer and are involved with metastasis. The present study tested the hypothesis thatPPARβ/δis expressed in human pancreatic cancer cells and that its activation could regulateMMP-9, decreasing cancer cells ability to transverse the basement membrane. In human pancreatic cancer tissue there was significantly higher expression ofMMP-9andPPARβ/δ, and lower levels ofBCL-6mRNA.PPARβ/δactivation reduced the TNFα-induced expression of various genes implicated in metastasis and reduced the invasion through a basement membrane in cell culture models. Through the use of short hairpin RNA inhibitors ofPPARβ/δ,BCL-6, andMMP-9, it was evident thatPPARβ/δwas responsible for the ligand-dependent effects whereasBCL-6dissociation upon GW501516 treatment was ultimately responsible for decreasingMMP-9expression and hence invasion activity. These results suggest thatPPARβ/δplays a role in regulating pancreatic cancer cell invasion through regulation of genes via ligand-dependent release ofBCL-6and that activation of the receptor may provide an alternative therapeutic method for controlling migration and metastasis.

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