scholarly journals Parathyroid Hormone-Related Protein: An Essential Physiological Regulator of Adult Bone Mass

Endocrinology ◽  
2004 ◽  
Vol 145 (8) ◽  
pp. 3551-3553 ◽  
Author(s):  
Alessandro Bisello ◽  
Mara J. Horwitz ◽  
Andrew F. Stewart
Keyword(s):  
Parathyroid Hormone ◽  
Bone Mass ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein ◽  
Physiological Regulator ◽  
Adult Bone

scholarly journals Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation

2004 ◽  
Vol 113 (3) ◽  
pp. 492-492
Author(s):  
Joshua N. VanHouten ◽  
Pamela Dann ◽  
Andrew F. Stewart ◽  
Christine J. Watson ◽  
Michael Pollak ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Bone Mass ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein ◽  
Specific Deletion

scholarly journals Variable number of tandem repeats polymorphism in parathyroid hormone-related protein as predictor of peak bone mass in young healthy Finnish males

2008 ◽  
Vol 158 (5) ◽  
pp. 755-764 ◽  
Author(s):  
Ajay Gupta ◽  
Ville-Valtteri Välimäki ◽  
Matti J Välimäki ◽  
Eliisa Löyttyniemi ◽  
Marilyn Richard ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Lumbar Spine ◽  
Bone Mass ◽  
Peak Bone Mass ◽  
Tandem Repeats ◽  
Broadband Ultrasound Attenuation ◽  
Variable Number ◽  
Related Protein ◽  
Mineral Density ◽  
Parathyroid Hormone Related Protein

ObjectiveMice with osteoblast-specific deletion of parathyroid hormone-related protein (PTHrP) exhibit impaired recruitment and increased apoptosis of osteogenic cells resulting in decreased bone formation and premature osteoporosis. The PTHrP levels within the bone microenvironment are therefore critical in influencing bone mass acquisition. Whether this is applicable in humans has not been established. Here, we studied the association of a variable number of tandem repeats (VNTR) polymorphism in PTHrP with peak bone mass.MethodsEnrolled in the study were 234 young Finnish males, with median age of 19.6 years (range 18.3–20.6 years). Lifestyle factors, serum bone markers, osteodensitometric measurements (lumbar spine and hip) and calcaneal quantitative ultrasound readings were obtained. The PTHrP VNTR length was determined by the PCR amplification of genomic DNA extracted from peripheral blood and correlated to bone parameters by the multiple regression models.ResultsThe presence of at least one 252 bp allele was associated with increased lumbar spine bone mineral density (BMD; P<0.0034), broadband ultrasound attenuation (BUA; P<0.0012) and speed-of-sound (SOS; P<0.0023) measurements. The correlation with increased lumbar spine BMD (P=0.0008), BUA (P=0.005) and SOS (P=0.001) was further strengthened by the pairing of the 252 bp allele with a 460 bp allele in comparison with those without any 252 bp allele. Electrophoretic mobility shift assays were used to illustrate the potential transcriptional functionality of the VNTR sequence.ConclusionThe results indicate that the PTHrP VNTR sequence likely modulates local PTHrP expression within the skeletal microenvironment and could serve as a diagnostic predictor of peak bone mass acquisition.

scholarly journals Mammary-specific deletion of parathyroid hormone–related protein preserves bone mass during lactation

2003 ◽  
Vol 112 (9) ◽  
pp. 1429-1436 ◽  
Author(s):  
Joshua N. VanHouten ◽  
Pamela Dann ◽  
Andrew F. Stewart ◽  
Christine J. Watson ◽  
Michael Pollak ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Bone Mass ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein ◽  
Specific Deletion

Parathyroid Hormone–Related Protein Inhibits Endothelin-1 Production

Hypertension ◽  
1996 ◽  
Vol 27 (3) ◽  
pp. 360-363 ◽  
Author(s):  
Bingbing Jiang ◽  
Shigeto Morimoto ◽  
Keisuke Fukuo ◽  
Atsushi Hirotani ◽  
Michio Tamatani ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Related Protein ◽  
Endothelin 1 ◽  
Parathyroid Hormone Related Protein

Parathyroid Hormone–Related Protein Upregulates Interleukin-1β–Induced Nitric Oxide Synthesis

Hypertension ◽  
1997 ◽  
Vol 30 (4) ◽  
pp. 922-927 ◽  
Author(s):  
Bingbing Jiang ◽  
Shigeto Morimoto ◽  
Jin Yang ◽  
Keisuke Fukuo ◽  
Atsushi Hirotani ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Parathyroid Hormone ◽  
Interleukin 1Β ◽  
Nitric Oxide Synthesis ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein
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