scholarly journals Cloning and Characterization of Granulosa Cell High-Mobility Group (HMG)-Box Protein-1, a Novel HMG-Box Transcriptional Regulator Strongly Expressed in Rat Ovarian Granulosa Cells

Endocrinology ◽  
2004 ◽  
Vol 145 (5) ◽  
pp. 2307-2318 ◽  
Author(s):  
Takashi Kajitani ◽  
Tetsuya Mizutani ◽  
Kazuya Yamada ◽  
Takashi Yazawa ◽  
Toshio Sekiguchi ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cells ◽  
High Mobility ◽  
Transcriptional Regulator ◽  
High Mobility Group ◽  
Hmg Box ◽  
Ovarian Granulosa Cells

Expression and regulation of high mobility group AT-hook 1 (HMGA1) during ovulation and luteinisation in rat ovary

2019 ◽  
Vol 31 (4) ◽  
pp. 698 ◽  
Author(s):  
Hao-ran Li ◽  
Yan Li ◽  
Yu Liu ◽  
Jiao-jiao Yu ◽  
Fei-xue Li
Keyword(s):  
Mrna Expression ◽  
Granulosa Cell ◽  
Cell Cultures ◽  
Granulosa Cells ◽  
In Situ Hybridisation ◽  
High Mobility ◽  
High Mobility Group ◽  
Female Rats ◽  
Corpora Lutea ◽  
Hmga1 Expression

High mobility group AT-hook 1 (HMGA1) is able to regulate gene expression and function as a tumour suppressor. The spatiotemporal expression pattern of HMGA1 was investigated in this study. Immature female rats (22–23 days old) were treated with 10IU, s.c., pregnant mare’s serum gonadotrophin to stimulate follicular development, followed 48h later by injection with 5IU, s.c., human chorionic gonadotrophin (hCG). Whole ovaries or granulosa cells were collected at various times after hCG administration (n=3 per time point). Real-time polymerase chain reaction and western blot analysis revealed that HMGA1 was highly stimulated in the ovary by 4–12h after hCG treatment. In situ hybridisation analysis demonstrated that Hmga1 mRNA expression was induced in granulosa cells between 8 and 12h after hCG treatment. There was negligible Hmga1 mRNA signal observed in newly forming corpora lutea. In addition, the data indicated that both the protein kinase (PK) A and PKC pathways regulated Hmga1 expression in rat granulosa cells. In rat granulosa cell cultures, upregulation of Hmga1 was dependent on new protein synthesis because Hmga1 was inhibited by cycloheximide. Furthermore, Hmga1 mRNA expression in rat granulosa cell cultures was inhibited by AG1478, whereas NS398 and RU486 had no effect, suggesting that Hmga1 expression was regulated, in part, by the epidermal growth factor pathway. In summary, the findings of this study suggest that induction of Hmga1 may be important for theca and granulosa cell differentiation into luteal cells.

scholarly journals Characterization of high mobility group protein levels during spermatogenesis in the rat.

1984 ◽  
Vol 259 (14) ◽  
pp. 8840-8846
Author(s):  
L R Bucci ◽  
W A Brock ◽  
I L Goldknopf ◽  
M L Meistrich
Keyword(s):  
High Mobility ◽  
High Mobility Group ◽  
High Mobility Group Protein ◽  
Protein Levels ◽  
Group Protein

scholarly journals Identification and Characterization of the Direct Interaction between Methotrexate (MTX) and High-Mobility Group Box 1 (HMGB1) Protein

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63073 ◽  
Author(s):  
Yuki Kuroiwa ◽  
Yoichi Takakusagi ◽  
Tomoe Kusayanagi ◽  
Kouji Kuramochi ◽  
Takahiko Imai ◽  
...  
Keyword(s):  
High Mobility ◽  
Direct Interaction ◽  
High Mobility Group ◽  
Hmgb1 Protein ◽  
Identification And Characterization

scholarly journals Di-(2-ethylhexyl) phthalate (DEHP) inhibits steroidogenesis and induces mitochondria-ROS mediated apoptosis in rat ovarian granulosa cells

2019 ◽  
Vol 8 (3) ◽  
pp. 381-394 ◽  
Author(s):  
Anima Tripathi ◽  
Vivek Pandey ◽  
Alakh N. Sahu ◽  
Alok Singh ◽  
Pawan K. Dubey
Keyword(s):  
Oxidative Stress ◽  
Granulosa Cell ◽  
Granulosa Cells ◽  
Ovarian Granulosa Cells ◽  
Ethylhexyl Phthalate

Increased oxidative stress (OS) due to ubiquitous exposure to di-(2-ethylhexyl) phthalate (DEHP) can affect the quality of oocytes by inducing apoptosis and hampering granulosa cell mediated steroidogenesis.

Characterization of human SMARCE1r high-mobility-group protein

2002 ◽  
Vol 1574 (3) ◽  
pp. 269-276 ◽  
Author(s):  
Young Mi Lee ◽  
Hyunjin Shin ◽  
Wonja Choi ◽  
Sungmin Ahn ◽  
Wankee Kim
Keyword(s):  
High Mobility ◽  
High Mobility Group ◽  
High Mobility Group Protein ◽  
Group Protein

Characterization of high mobility group protein binding to cisplatin-damaged DNA

1992 ◽  
Vol 188 (3) ◽  
pp. 1286-1294 ◽  
Author(s):  
Paul C. Billings ◽  
Richard J. Davis ◽  
Beatrice N. Engelsberg ◽  
Kirsten A. Skov ◽  
Edward N. Hughes
Keyword(s):  
Protein Binding ◽  
High Mobility ◽  
High Mobility Group ◽  
High Mobility Group Protein ◽  
Group Protein ◽  
Damaged Dna

scholarly journals Characterization of Three Abundant mRNAs from Human Ovarian Granulosa Cells

1990 ◽  
Vol 9 (7) ◽  
pp. 479-485 ◽  
Author(s):  
G. RAPP ◽  
J. FREUDENSTEIN ◽  
J. KLAUDINY ◽  
J. MUCHA ◽  
F. WEMPE ◽  
...  
Keyword(s):  
Granulosa Cells ◽  
Ovarian Granulosa Cells

scholarly journals Characterization of a High Mobility Group 1/2 Homolog in Yeast

1996 ◽  
Vol 271 (52) ◽  
pp. 33678-33685 ◽  
Author(s):  
Jian Lu ◽  
Ryuji Kobayashi ◽  
Steven J. Brill
Keyword(s):  
High Mobility ◽  
High Mobility Group ◽  
Group 1
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