scholarly journals Expression of Fibroblast Growth Factor Receptor-3 (FGFR3), Signal Transducer and Activator of Transcription-1, and Cyclin-Dependent Kinase Inhibitor p21 during Endochondral Ossification: Differential Role of FGFR3 in Skeletal Development and Fracture Repair

Endocrinology ◽  
2003 ◽  
Vol 144 (10) ◽  
pp. 4659-4668 ◽  
Author(s):  
Arata Nakajima ◽  
Sumito Shimizu ◽  
Hideshige Moriya ◽  
Masashi Yamazaki
Keyword(s):  
Endochondral Ossification ◽  
Fibroblast Growth Factor Receptor ◽  
Kinase Inhibitor ◽  
Skeletal Development ◽  
Growth Factor Receptor ◽  
Fracture Repair ◽  
Signal Transducer ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase Inhibitor

scholarly journals The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics

Cancers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1475 ◽  
Author(s):  
Al Bitar ◽  
Gali-Muhtasib
Keyword(s):  
Cell Cycle Progression ◽  
Molecular Mechanisms ◽  
Kinase Inhibitor ◽  
Biological Activities ◽  
Cyclin Dependent Kinase ◽  
Cycle Progression ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Multiple Signaling ◽  
Made In

p21cip1/waf1 mediates various biological activities by sensing and responding to multiple stimuli, via p53-dependent and independent pathways. p21 is known to act as a tumor suppressor mainly by inhibiting cell cycle progression and allowing DNA repair. Significant advances have been made in elucidating the potential role of p21 in promoting tumorigenesis. Here, we discuss the involvement of p21 in multiple signaling pathways, its dual role in cancer, and the importance of understanding its paradoxical functions for effectively designing therapeutic strategies that could selectively inhibit its oncogenic activities, override resistance to therapy and yet preserve its tumor suppressive functions.

A potential role of cyclin-dependent kinase inhibitor 1 (p21/WAF1) in the pathogenesis of endometriosis: Directions for future research

2019 ◽  
Vol 133 ◽  
pp. 109414
Author(s):  
Nikolaos Zarkadoulas ◽  
Vasilios Pergialiotis ◽  
Dimitrios Dimitroulis ◽  
Konstantinos Stefanidis ◽  
Christos Verikokos ◽  
...  
Keyword(s):  
Potential Role ◽  
Kinase Inhibitor ◽  
Future Research ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase Inhibitor ◽  
P21 Waf1

Role of the Cyclin-Dependent Kinase Inhibitor CDKN2A in Familial Melanoma

1998 ◽  
Vol 2 (3) ◽  
pp. 172-179 ◽  
Author(s):  
David Hogg ◽  
Herbert Brill ◽  
Ling Liu ◽  
Jose Monzon ◽  
Anne Summers ◽  
...  
Keyword(s):  
Autosomal Dominant ◽  
Kinase Inhibitor ◽  
Early Stage ◽  
Surgical Excision ◽  
Cyclin Dependent Kinase ◽  
Dominant Form ◽  
Familial Melanoma ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Autosomal Dominant Form

Background: Approximately 8 to 12% of melanoma appears to be inherited in an autosomal dominant form. Although most early stage melanomas can be treated successfully by simple surgical excision, patients with advanced disease are rarely cured even with aggressive chemotherapy and/or immunotherapy. Objective: There is now compelling evidence that germline mutations of the CDKN2A gene on chromosome 9p21 predispose to melanoma in a subset of melanoma-prone families. In this article the evidence for the role of CDKN2A in the genesis of familial melanoma is reviewed and the implications of genetic testing in families with this disease are discussed. Conclusion: The identification and subsequent surveillance of unaffected individuals who have a genetic predisposition to melanoma may lead to the detection of early (curable) melanomas and to a reduction in mortality.

scholarly journals The Role of Cyclin-dependent Kinase Inhibitor p27Kip1in Anti-HER2 Antibody-induced G1Cell Cycle Arrest and Tumor Growth Inhibition

2003 ◽  
Vol 278 (26) ◽  
pp. 23441-23450 ◽  
Author(s):  
Xiao-Feng Le ◽  
Francois-Xavier Claret ◽  
Amy Lammayot ◽  
Ling Tian ◽  
Deepa Deshpande ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Growth Inhibition ◽  
Kinase Inhibitor ◽  
Tumor Growth Inhibition ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Cycle Arrest
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