scholarly journals Sp3/Sp1 in the Parathyroid Gland: Identification of an Sp1 Deoxyribonucleic Acid Element in the Parathyroid Hormone Promoter

Endocrinology ◽  
2003 ◽  
Vol 144 (7) ◽  
pp. 3138-3147 ◽  
Author(s):  
Alexander P. Alimov ◽  
M. Chris Langub ◽  
Hartmut H. Malluche ◽  
Nicholas J. Koszewski
Keyword(s):  
Parathyroid Hormone ◽  
Parathyroid Gland ◽  
Deoxyribonucleic Acid ◽  
Acid Element

scholarly journals Contrasting Mammalian Parathyroid Hormone (PTH) Promoters: Nuclear Factor-Y Binds to a Deoxyribonucleic Acid Element Unique to the Human PTH Promoter and Acts as a Transcriptional Enhancer

Endocrinology ◽  
2004 ◽  
Vol 145 (6) ◽  
pp. 2713-2720 ◽  
Author(s):  
Alexander P. Alimov ◽  
M. Chris Langub ◽  
Hartmut H. Malluche ◽  
Ok-Kyong Park-Sarge ◽  
Nicholas J. Koszewski
Keyword(s):  
Parathyroid Hormone ◽  
Deoxyribonucleic Acid ◽  
Nuclear Factor ◽  
Transcriptional Enhancer ◽  
Nuclear Factor Y ◽  
Acid Element

Studies on the Biosynthesis of Rat Parathyroid Hormone and Proparathyroid Hormone: Adaptation of the Parathyroid Gland to Dietary Restriction of Calcium1

Endocrinology ◽  
1973 ◽  
Vol 93 (4) ◽  
pp. 915-924 ◽  
Author(s):  
LUKE L. H. CHU ◽  
RONAL R. MACGREGOR ◽  
CONSTANTINE S. ANAST ◽  
JAMES W. HAMILTON ◽  
DAVID V. COHN
Keyword(s):  
Parathyroid Hormone ◽  
Parathyroid Gland ◽  
Dietary Restriction

The Sigmoidal Parathyroid Hormone-Ionized Calcium Curve and the Set Point of Calcium in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis

1993 ◽  
Vol 13 (2_suppl) ◽  
pp. 476-479 ◽  
Author(s):  
Fabio Malberti ◽  
Bruno Corradi ◽  
Bruno Pagliari ◽  
Dino Romanini ◽  
Antonietta Gazo ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Parathyroid Hormone ◽  
Parathyroid Gland ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Ionized Calcium ◽  
Set Point ◽  
High Incidence ◽  
Adynamic Bone ◽  
The Right ◽  
Aluminum Intoxication

A high Incidence of adynamic bone disease not related to aluminum Intoxication has been reported In continuous ambulatory peritoneal dialysis (CAPD). Since reduced parathyroid hormone (PTH) secretion may predispose to adynamic bone, we Investigated whether parathyroid gland sensitivity may be depressed In CAPD in comparison with hemodialysis (HD). Thus we determined parathyraid function by the evaluation of the PTH-ionized calcium (ICa) relationship, which was obtained Inducing hypocalcemia and hypercalcemia In 19 CAPD and 18 HD patients with biochemical and histological evidence of mild (MILD) or severe (OF) hyperparathyroidism, but negative stainable bone aluminum. Either CAPD or HD patients with OF showed a shift to the right of the sigmoidal PTH-ICa curve in comparison with patients with MILD, greater set point of calcium, and maximal PTH stimulation and Inhibition. The PTH-lCa curve and the other parathyraid function parameters were not different in CAPD and HD patients within the same bone histological group. In conclusion, our data document that parathyroid gland activity Is stimulated either in CAPD and HD patients with OF, but is not depressed in CAPD patients in comparison with HD patients.

Minimally Invasive Parathyroid Surgery, The Norman 20% Rule: Is It Valid?

2011 ◽  
Vol 77 (4) ◽  
pp. 484-487 ◽  
Author(s):  
Amy R. Quillo ◽  
Jeffery M. Bumpous ◽  
Richard E. Goldstein ◽  
Muffin M. Fleming ◽  
Ccrp ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Minimally Invasive ◽  
Parathyroid Gland ◽  
Ex Vivo ◽  
Frozen Section ◽  
Postoperative Management ◽  
Average Percentage ◽  
Parathyroid Hormone Monitoring ◽  
Intraoperative Parathyroid Hormone

The 20 per cent rule proposed by Norman established a guideline using radioactivity in the minimally invasive radioguided parathyroidectomy (MIRP) technique to localize and confirm removal of an abnormal parathyroid gland in patients with primary hyperparathyroidism. If radioactivity in the resected gland was at least 20 per cent of excision site/background radioactivity, the 20 per cent rule was satisfied. Patients meeting these criteria underwent unilateral MIRP without intraoperative parathyroid hormone assay or intraoperative frozen section. The study aim was to independently evaluate the 20 per cent rule in MIRP patients with primary hyperparathyroidism. Using the University of Louisville Parathyroid Database from January 1, 1999 to December 31, 2007, 216 MIRP patients with complete radioguided and postoperative management data were identified. The average percentage of ex vivo parathyroid gland radioactivity compared with excision site/background radioactivity was 107 per cent with a range from 14 to 388 per cent. For 99 per cent (196/198) radioactivity recorded from the excised gland was at least 20 per cent of radioactivity recorded from the excision site. Normocalcemia was documented in 98.5 per cent (195/198) at 12 month follow-up. Our data supports the 20 per cent rule in that in 99 per cent of MIRP patients the resected gland radioactivity was at least 20 per cent of excision site radioactivity allowing localization and confirmation of an overactive gland without intraoperative parathyroid hormone monitoring or tissue analysis.

scholarly journals Large carboxy-terminal parathyroid hormone (PTH) fragment with a relatively longer half-life than 1-84 PTH is secreted directly from the parathyroid gland in humans

2003 ◽  
pp. 301-306 ◽  
Author(s):  
H Yamashita ◽  
P Gao ◽  
T Cantor ◽  
T Futata ◽  
T Murakami ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Parathyroid Gland ◽  
Half Life ◽  
Contralateral Side ◽  
Study Group ◽  
Blood Samples ◽  
Glandular Secretion ◽  
Whole Pth ◽  
Ultrasonographic Guidance ◽  
Carboxy Terminal

OBJECTIVE: It was discovered that an immunoreactive large carboxy-terminal parathyroid hormone (PTH) fragment (large C-PTH), likely 7-84 PTH, is present in the circulation. However, very little is known about the production and metabolism of this large C-PTH. Combining a whole molecule PTH (whole PTH) immunoradiometric assay (IRMA) specifically for 1-84 PTH and an intact PTH (iPTH) IRMA for the sum of 1-84 PTH and large C-PTH, we were able to assess the circulating level of this large C-PTH as well as the glandular secretion and metabolism of this large C-PTH in primary hyperparathyroidism (pHPT). METHODS: This study consisted of two patient groups consisting of 77 pHPT patients with a single adenoma. Of these, 43 comprised the venous sampling study group and 70 comprised the intra-operative PTH study group. (Seven patients belonged only to the former group, 34 patients to only the latter group, and 36 patients to both groups.) Preoperatively, blood samples were drawn from the bilateral internal jugular vein by ultrasonographic guidance and from the peripheral vein (n=43). During surgery, blood samples were drawn after anesthesia (basal level), before excision (pre-excision level) of one enlarged parathyroid gland, and at 5, 10, and 15 min post-excision (n=70). RESULTS: There were 26 patients whose iPTH assay levels differed by more than 10% between the right and left internal jugular. In 24 of the 26 patients, the large C-PTH levels obtained from the adenoma side were significantly higher than those from the contralateral side (117+/-135 vs 43+/-33 pg/ml, P<0.001). The plasma whole PTH values decreased more rapidly than the iPTH values after parathyroidectomy (P<0.001). CONCLUSIONS: Our study has demonstrated that the large C-PTH, likely 7-84 PTH, is directly released from the parathyroid gland in humans. Since the half-life of 1-84 PTH is much shorter than large C-PTH, likely 7-84 PTH, it would be advantageous to use an assay that specifically measures 1-84 PTH for intra-operative monitoring of parathyroidectomy.

Hypocalcemia in magnesium-depleted dogs: Evidence for reduced responsiveness to parathyroid hormone and relative failure of parathyroid gland function

Metabolism ◽  
1974 ◽  
Vol 23 (4) ◽  
pp. 323-335 ◽  
Author(s):  
Joseph Levi ◽  
Shaul G. Massry ◽  
Jack W. Coburn ◽  
Francisco Llach ◽  
Charles R. Kleeman
Keyword(s):  
Parathyroid Hormone ◽  
Parathyroid Gland ◽  
Gland Function
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