scholarly journals Taste masking of ondansetron hydrochloride by polymer carrier system and formulation of rapid-disintegrating tablets

2007 ◽  
Vol 8 (2) ◽  
pp. E127-E133 ◽  
Author(s):  
Shagufta Khan ◽  
Prashant Kataria ◽  
Premchand Nakhat ◽  
Pramod Yeole
Keyword(s):  
Taste Masking ◽  
Carrier System ◽  
Polymer Carrier ◽  
Ondansetron Hydrochloride

Taste Masking of Lornoxicam by polymer carrier system and formulation of oral disintegrating tablets.

2009 ◽  
Vol 1 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Rajesh S. Jadon ◽  
Swadesh Nayak ◽  
Sabita Amlan ◽  
Vikas Deep Vaidya ◽  
Prashant Khemariya ◽  
...  
Keyword(s):  
Taste Masking ◽  
Carrier System ◽  
Polymer Carrier

scholarly journals Copolymer Involving 2-Hydroxyethyl Methacrylate and 2-Chloroquinyl Methacrylate: Synthesis, Characterization and In Vitro 2-Hydroxychloroquine Delivery Application

Polymers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 4072
Author(s):  
Abeer Aljubailah ◽  
Wafa Nazzal Odis Alharbi ◽  
Ahmed S. Haidyrah ◽  
Tahani Saad Al-Garni ◽  
Waseem Sharaf Saeed ◽  
...  
Keyword(s):  
Drug Carrier ◽  
Cancer Cell Line ◽  
Esterification Reaction ◽  
Hydroxyethyl Methacrylate ◽  
Carrier System ◽  
Free Radical Copolymerization ◽  
Polymer Carrier ◽  
Elementary Analysis ◽  
Drug Carrier System

The Poly(2-chloroquinyl methacrylate-co-2-hydroxyethyl methacrylate) (CQMA-co-HEMA) drug carrier system was prepared with different compositions through a free-radical copolymerization route involving 2-chloroquinyl methacrylate (CQMA) and 2-hydroxyethyl methacrylate) (HEMA) using azobisisobutyronitrile as the initiator. 2-Chloroquinyl methacrylate monomer (CQMA) was synthesized from 2-hydroxychloroquine (HCQ) and methacryloyl chloride by an esterification reaction using triethylenetetramine as the catalyst. The structure of the CQMA and CQMA-co-HEMA copolymers was confirmed by a CHN elementary analysis, Fourier transform infra-red (FTIR) and nuclear magnetic resonance (NMR) analysis. The absence of residual aggregates of HCQ or HCQMA particles in the copolymers prepared was confirmed by a differential scanning calorimeter (DSC) and XR-diffraction (XRD) analyses. The gingival epithelial cancer cell line (Ca9-22) toxicity examined by a lactate dehydrogenase (LDH) assay revealed that the grafting of HCQ onto PHEMA slightly affected (4.2–9.5%) the viability of the polymer carrier. The cell adhesion and growth on the CQMA-co-HEMA drug carrier specimens carried out by the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay revealed the best performance with the specimen containing 3.96 wt% HCQ. The diffusion of HCQ through the polymer matrix obeyed the Fickian model. The solubility of HCQ in different media was improved, in which more than 5.22 times of the solubility of HCQ powder in water was obtained. According to Belzer, the in vitro HCQ dynamic release revealed the best performance with the drug carrier system containing 4.70 wt% CQMA.

Taste Masking and Formulation of Ondansetron Hydrochloride Mouth Dissolving Tablets

2015 ◽  
Vol 5 (3) ◽  
Author(s):  
Subedi R. ◽  
Poudel K. ◽  
Budhathoki U ◽  
Thapa P.
Keyword(s):  
Bitter Taste ◽  
Drug Loading ◽  
Taste Masking ◽  
Complexing Agent ◽  
Dissolution Profile ◽  
Disintegration Time ◽  
Sodium Starch Glycolate ◽  
Ondansetron Hydrochloride ◽  
Croscarmellose Sodium ◽  
Mouth Dissolving Tablet

This study was done to mask the bitter taste of ondansetron HCl using complexing agent, a polacrilex resin: Tulsion 335 and subsequently forming mouth dissolving tablet using superdisintegrants: Croscarmellose sodium and sodium starch glycollate. A preliminary screening was done. Batch process, a most preferential method for drug loading with ion exchange resins was selected. The process was optimized for drug: resin ratio to get maximum drug loading. A ratio of drug: resin at 1:3 was selected. Taste evaluation was carried out by selecting volunteers. Drug resin complex (DRC) was evaluated for drug release. The resultant DRC was formulated by direct compression into mouth dissolving tablet using microcrystalline cellulose PH 102, as diluent and croscarmalose sodium and sodium starch glycolate as superdisintegrants and aspartame was used as sweetening agent to enhance palatability. Thirteen formulations were developed by using superdisintegrants: croscarmellose sodium and sodium starch glycolate. Concentration of superdisintegrants ranged from 0.75-9.24 %. The formulated tablet had satisfactory disintegration time and dissolution profile. Optimization was carried out using central composite design. The disintegration and dissolution times were tallied with marketed ondansetron HCl tablets. From the results, it was deduced that the most effective concentration for desired disintegration was of croscarmellose sodium and sodium starch glycollate respectively at concentration above 5%. Therefore, it can be concluded that the intensely bitter taste of ondansetron HCl can be masked by using tulsion 335 and mouth dissolving ondansetron HCl can be successfully prepared by adding aforementioned superdisintegrants. This sort of mouth dissolving ondansetron HCl can be used in controlling vomiting in paediatric and geriatric patients and also for pregnancy induced vomiting.

Does the polyamine carrier system absorb basic amino acids?

2001 ◽  
Vol 120 (5) ◽  
pp. A142-A142
Author(s):  
J GASKEY ◽  
E SEIDEL
Keyword(s):  
Amino Acids ◽  
Carrier System ◽  
Basic Amino Acids

Pharmaceutical Polymers - A Review

2019 ◽  
Vol 9 (01) ◽  
pp. 27-33
Author(s):  
Naveen Kumar ◽  
Sonia Pahuja ◽  
Ranjit Sharma
Keyword(s):  
Drug Release ◽  
Industrial Revolution ◽  
Pharmaceutical Formulations ◽  
Pharmaceutical Products ◽  
Water Soluble ◽  
Taste Masking ◽  
Natural Polymers ◽  
Pharmaceutical Dosage Forms ◽  
Pharmaceutical Applications ◽  
Pharmaceutical Industries

Humans have taken advantage of the adaptability of polymers for centuries in the form of resins, gums tars, and oils. However, it was not until the industrial revolution that the modern polymer industry began to develop. Polymers represent an important constituent of pharmaceutical dosage forms. Polymers have played vital roles in the formulation of pharmaceutical products. Polymers have been used as a major tool to manage the drug release rate from the formulations. Synthetic and natural-based polymers have found their way into the biomedical and pharmaceutical industries. Synthetic and Natural polymers can be produced with a broad range of strength, heat resistance, density, stiffness and even price. By constant research into the science and applications of polymers, they are playing an ever-increasing role in society. Diverse applications of polymers in the present pharmaceutical field are for controlled drug release. Based on solubility pharmaceutical polymers can be classified as water-soluble and water-insoluble. In general, the desirable polymer properties in pharmaceutical applications are film forming, adhesion, gelling, thickening, pH-dependent solubility and taste masking. General pharmaceutical applications of polymers in various pharmaceutical formulations are also discussed

Aquasomes: A Self Assembling Nanobiopharmaceutical Carrier System for Bio-Active Molecules: A Review

2012 ◽  
Vol 1 (1) ◽  
pp. 11-21 ◽  
Author(s):  
J.K. Patel ◽  
K.N. Patel ◽  
H.K. Patel ◽  
B.A. Patel ◽  
P.A. Patel
Keyword(s):  
Carrier System ◽  
Self Assembling
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