scholarly journals Preparation and in vivo toxicity study of solid lipid microparticles as carrier for pulmonary administration

2004 ◽  
Vol 5 (2) ◽  
pp. 17-23 ◽  
Author(s):  
Vanna Sanna ◽  
Nathalie Kirschvink ◽  
Pascal Gustin ◽  
Elisabeta Gavini ◽  
Isabelle Roland ◽  
...  
Keyword(s):  
Toxicity Study ◽  
In Vivo Toxicity ◽  
Pulmonary Administration ◽  
Solid Lipid ◽  
Solid Lipid Microparticles ◽  
Lipid Microparticles

Development, in vitro and in vivo Evaluations of Solid-Lipid Microparticles based on Solidified Micellar Carrier System for Oral Delivery of Cefepime

2017 ◽  
Vol 10 (1) ◽  
pp. 3582-3593
Author(s):  
Chukwuebuka Umeyor ◽  
Uchechukwu Nnadozie ◽  
Anthony Attama
Keyword(s):  
Oral Delivery ◽  
In Vitro Release ◽  
Carrier System ◽  
Solid Lipid ◽  
Solid Lipid Microparticles ◽  
Release Study ◽  
Lipid Microparticles ◽  
Vitro Release

This study seeks to formulate and evaluate a solid lipid nanoparticle-based, solidified micellar carrier system for oral delivery of cefepime. Cefepime has enjoyed a lot of therapeutic usage in the treatment of susceptible bacterial infections; however, its use is limited due to its administration as an injection only with poor patient compliance. Since oral drug administration encourage high patient compliance with resultant effect in improved therapy, cefepime was formulated as solid lipid microparticles for oral delivery using the concept of solidified micellar carrier system. The carrier system was evaluated based on particle yield, particle size and morphology, encapsulation efficiency (EE %), and thermal analysis using differential scanning calorimeter (DSC). Preliminary microbiological studies were done using gram positive and negative bacteria. In vitro release study was performed using biorelevant media, while in vivo release study was performed in white albino rats. The yield of solid lipid microparticles (SLM) ranged from 84.2 – 98.0 %. The SLM were spherical with size ranges of 3.8 ± 1.2 to 42.0 ± 1.4 µm. The EE % calculated ranged from 83.6 – 94.8 %. Thermal analysis showed that SLM was less crystalline with high potential for drug entrapment. Microbial studies showed that cefepime retained its broad spectrum anti-bacterial activity. In vitro release showed sustained release of cefepime from SLM, and in vivo release study showed high concentration of cefepime released in the plasma of study rats. The study showed that smart engineering of solidified micellar carrier system could be used to improve oral delivery of cefepime.

Formulation of Novel Artesunate-Loaded Solid Lipid Microparticles (SLMs) Based on Dika Wax Matrices: In Vitro and in Vivo Evaluation

2014 ◽  
Vol 24 (1) ◽  
pp. 69-77 ◽  
Author(s):  
E.E. Chinaeke ◽  
S.A. Chime ◽  
F.C. Kenechukwu ◽  
C.C. Müller-Goymann ◽  
A.A. Attama ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Solid Lipid ◽  
Solid Lipid Microparticles ◽  
Lipid Microparticles

Development and characterization of solid lipid microparticles loaded with ascorbic acid and produced by spray congealing

2015 ◽  
Vol 67 ◽  
pp. 52-59 ◽  
Author(s):  
Fernando Eustáquio Matos-Jr ◽  
Marcello Di Sabatino ◽  
Nadia Passerini ◽  
Carmen Sílvia Favaro-Trindade ◽  
Beatrice Albertini
Keyword(s):  
Ascorbic Acid ◽  
Solid Lipid ◽  
Solid Lipid Microparticles ◽  
Lipid Microparticles

Solid lipid microparticles loaded with cinnamon oleoresin: Characterization, stability and antimicrobial activity

2018 ◽  
Vol 113 ◽  
pp. 351-361 ◽  
Author(s):  
Fernanda Ramalho Procopio ◽  
Vivian Boesso Oriani ◽  
Bruno Nicolau Paulino ◽  
Leonardo do Prado-Silva ◽  
Glaucia Maria Pastore ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Solid Lipid ◽  
Solid Lipid Microparticles ◽  
Lipid Microparticles

scholarly journals Formulation And Evaluation Of Acyclovir Sodium Solid Lipid Microparticles

2016 ◽  
Vol 04 (05) ◽  
Author(s):  
Anantha Naik Nagappa ◽  
Gaurav Agarwal ◽  
Vinuth Chikkamath ◽  
Shilpi Agarwal ◽  
Rekha Rani ◽  
...  
Keyword(s):  
Solid Lipid ◽  
Solid Lipid Microparticles ◽  
Lipid Microparticles
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