scholarly journals Effect of polyols on the conformational stability and biological activity of a model protein lysozyme

2003 ◽  
Vol 4 (3) ◽  
pp. 101-109 ◽  
Author(s):  
Somnath Singh ◽  
Jagdish Singh
Keyword(s):  
Biological Activity ◽  
Conformational Stability ◽  
Model Protein

Contribution of Chain Termini to the Conformational Stability and Biological Activity of Onconase†

Biochemistry ◽  
2001 ◽  
Vol 40 (31) ◽  
pp. 9097-9103 ◽  
Author(s):  
Eugenio Notomista ◽  
Francesca Catanzano ◽  
Giuseppe Graziano ◽  
Sonia Di Gaetano ◽  
Guido Barone ◽  
...  
Keyword(s):  
Biological Activity ◽  
Conformational Stability

Biological activity and conformational stability of the domains of plasma fibronectin

1981 ◽  
Vol 212 (2) ◽  
pp. 515-524 ◽  
Author(s):  
Donald G. Wallace ◽  
John W. Donovan ◽  
Phillip M. Schneider ◽  
Ann M. Meunier ◽  
John L. Lundblad
Keyword(s):  
Biological Activity ◽  
Conformational Stability ◽  
Plasma Fibronectin

The Release and Bioactivity of Lysozyme from Selected Sol-Gel Derived SiO2 Matrices

2008 ◽  
Vol 396-398 ◽  
pp. 547-550 ◽  
Author(s):  
Timothy Wilson ◽  
Reeta Viitala ◽  
Mervi Puska ◽  
Harry Jalonen ◽  
Risto Penttinen ◽  
...  
Keyword(s):  
Biological Activity ◽  
Drug Release ◽  
Sol Gel ◽  
Drug Carriers ◽  
Therapeutic Agents ◽  
Protective Agent ◽  
Small Proteins ◽  
Different Types ◽  
Model Protein

Local drug release has many benefits – a steadier distribution, improved compliance, but most importantly it allows the convenient use of protein based molecules as therapeutic agents. Many different types of materials have been studied as drug carriers, including sol-gel derived SiO2 matrices. In this study lysozyme was used as a model protein and its release from prepared SiO2 monoliths and its biological activity thereafter was studied spectroscopically. Sucrose was used in some preparations to assess its ability to function as a protective agent during storing. Lysozyme release and bioactivity was similar in both preparations containing it when tested fresh. In monoliths stored for ten weeks, however, differences were observed in the biological activity of released lysozyme. In the preparations containing sucrose, lysozyme had retained its activity, while it was virtually nil in the preparations containing only lysozyme. This shows that sol-gel derived SiO2 matrices can be used as carriers for small proteins and that sucrose can function as a protective agent in them.

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

Effects of Vincristine on Endothelial Microtubules in the Spinal Cord

1976 ◽  
Vol 34 ◽  
pp. 58-59
Author(s):  
John L. Beggs ◽  
John D. Waggener ◽  
Wanda Miller
Keyword(s):  
Spinal Cord ◽  
Biological Activity ◽  
Horseradish Peroxidase ◽  
Transport Mechanism ◽  
Vasogenic Edema ◽  
Vesicular Transport ◽  
Close Proximity

Microtubules (MT) are versatile organelles participating in a wide variety of biological activity. MT involvement in the movement and transport of cytoplasmic components has been well documented. In the course of our study on trauma-induced vasogenic edema in the spinal cord we have concluded that endothelial vesicles contribute to the edema process. Using horseradish peroxidase as a vascular tracer, labeled endothelial vesicles were present in all situations expected if a vesicular transport mechanism was in operation. Frequently,labeled vesicles coalesced to form channels that appeared to traverse the endothelium. The presence of MT in close proximity to labeled vesicles sugg ested that MT may play a role in vesicular activity.

Isothiazol-3(2 H )-ones, Part I: Synthesis, Reactions and Biological Activity

2002 ◽  
Vol 23 (1) ◽  
pp. 79-121 ◽  
Author(s):  
Kathleen Taubert ◽  
Susanne Kraus ◽  
Bärbel Schulze
Keyword(s):  
Biological Activity ◽  
Synthesis Reactions
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