scholarly journals Multimodal particle size distributions emitted from HFA-134a solution pressurized metered-dose inhalers

2003 ◽  
Vol 4 (3) ◽  
pp. 76-86 ◽  
Author(s):  
Hugh D. C. Smyth
Keyword(s):  
Particle Size ◽  
Size Distributions ◽  
Metered Dose Inhalers ◽  
Particle Size Distributions ◽  
Metered Dose ◽  
Pressurized Metered Dose Inhalers

scholarly journals Tuning Aerosol Particle Size Distribution of Metered Dose Inhalers Using Cosolvents and Surfactants

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Imran Y. Saleem ◽  
Hugh D. C. Smyth
Keyword(s):  
Particle Size ◽  
Fine Particle ◽  
Laser Diffraction ◽  
Particle Sizes ◽  
Size Distributions ◽  
Metered Dose Inhalers ◽  
Particle Size Distributions ◽  
Metered Dose ◽  
Aerosol Particle Size ◽  
Median Particle

Objectives.The purpose of these studies was to understand the influence of cosolvent and surfactant contributions to particle size distributions emitted from solution metered dose inhalers (pMDIs) based on the propellant HFA 227.Methods.Two sets of formulations were prepared: (a) pMDIs-HFA 227 containing cosolvent (5–15% w/w ethanol) with constant surfactant (pluronic) concentration and (b) pMDIs-HFA 227 containing surfactant (0–5.45% w/w pluronic) with constant cosolvent concentration. Particle size distributions emitted from these pMDIs were analyzed using aerodynamic characterization (inertial impaction) and laser diffraction methods.Results. Both cosolvent and surfactant concentrations were positively correlated with median particle sizes; that is, drug particle size increased with increasing ethanol and pluronic concentrations. However, evaluation of particle size distributions showed that cosolvent caused reduction in the fine particle mode magnitude while the surfactant caused a shift in the mode position. These findings highlight the different mechanisms by which these components influence droplet formation and demonstrate the ability to utilize the different effects in formulations of pMDI-HFA 227 for independently modulating particle sizes in the respirable region.Conclusion. Potentially, the formulation design window generated using these excipients in combination could be used to match the particle size output of reformulated products to preexisting pMDI products.

254. A Comparison of the Particle Size Distributions for Aerosols Generated During Wet Grinding and Dry Deburring of Beryllium

1999 ◽  
Author(s):  
K.K. Ellis ◽  
R. Buchan ◽  
M. Hoover ◽  
J. Martyny ◽  
B. Bucher-Bartleson ◽  
...  
Keyword(s):  
Particle Size ◽  
Size Distributions ◽  
Particle Size Distributions ◽  
Wet Grinding
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