scholarly journals Influence of ibuprofen as a solid-state plasticizer in eudragit® RS 30 D on the physicochemical properties of coated beads

2001 ◽  
Vol 2 (4) ◽  
pp. 35-43 ◽  
Author(s):  
Chuanbin Wu ◽  
James W. McGinity
Keyword(s):  
Solid State ◽  
Physicochemical Properties

scholarly journals Thermal and long period stability of series of V(V), V(IV) and V(III) complex with Schiff base ligands in solid state

2019 ◽  
Vol 4 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Janusz Szklarzewicz ◽  
Anna Jurowska ◽  
Maciej Hodorowicz ◽  
Ryszard Gryboś
Keyword(s):  
Thermal Stability ◽  
Schiff Base ◽  
Solid State ◽  
Physicochemical Properties ◽  
General Formula ◽  
Oxidation State ◽  
Magnetic Moment ◽  
Tridentate Ligand ◽  
Schiff Base Ligands ◽  
Long Period

The synthesis and physicochemical properties of three new complexes of vanadium at +5, +4 and +3 oxidation state are described and discussed. The octahedral surrounding of vanadium for V(III) complexes of [V(L1)(HL1)] general formula is filled with two ONO tridentate ligand L, for V(IV) one ONO ligand L, oxido ligand and 1,10-phenanthroline (phen) as a co-ligand are presented in complexes of [VO(L2)(phen)]. For V(V) the complexes of [VO2(L1)(solv)] type were formed. As ligands, the H2L Schiff bases were formed in reaction between 5-hydroxysalcylaldehyde and phenylacetic hydrazide (H2L1) and 3,5-dichlorosalicyaldehyde and 4-hydroxybenzhydrazide (L2). The magnetic moment measurements, in 8 year period, show, that V(III) complexes slowly oxidise to V(IV) with preservation of the nonoxido character of the complexes, while V(IV) complexes were found to be stable. The TG and SDTA measurements indicate, that thermal stability depends mainly on the oxidation state of vanadium. The less thermally stable are the V(V) complexes, while V(IV) and V(III) are stable up to ca. 200oC. In solution, at pH 2 (similar to that in human digestion system), again the V(IV) are the most stable, only at pH 7.0 V(III) complexes had higher stability. The most stable, thus best for pharmaceutical use, are V(IV) complexes.

scholarly journals Polymorphism in Sulfadimidine/4-Aminosalicylic Acid Cocrystals: Solid-State Characterization and Physicochemical Properties

2015 ◽  
Vol 104 (4) ◽  
pp. 1385-1398 ◽  
Author(s):  
Christine Grossjohann ◽  
Dolores R. Serrano ◽  
Krzysztof J. Paluch ◽  
Peter O’Connell ◽  
Liana Vella-Zarb ◽  
...  
Keyword(s):  
Solid State ◽  
Physicochemical Properties ◽  
Aminosalicylic Acid ◽  
Solid State Characterization

Tosylate salts of the anticancer drug lapatinib

2013 ◽  
Vol 69 (12) ◽  
pp. 1516-1523 ◽  
Author(s):  
K. Ravikumar ◽  
B. Sridhar ◽  
Jagadeesh Babu Nanubolu ◽  
A. K. S. Bhujanga Rao ◽  
R. Jyothiprasad
Keyword(s):  
Solid State ◽  
Hydrogen Bonds ◽  
Physicochemical Properties ◽  
Anticancer Drug ◽  
Ring System ◽  
Nonbonded Interactions ◽  
One Dimensional ◽  
Drug Products ◽  
Ring Motif

Two tosylate salts of an anticancer drug lapatinib,viz. a monotosylate [systematic name: ({5-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}amino)quinazolin-6-yl]furan-2-yl}methyl)[2-(methylsulfonyl)ethyl]azanium 4-methylbenzenesulfonate], C29H27ClFN4O4S+·C7H7O3S−, (I), and a ditosylate [systematic name: 4-({3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}amino)-6-]5-({[2-(methylsulfonyl)ethyl]azaniumyl}methyl)furan-2-yl[quinazolin-1-ium bis(4-methylbenzenesulfonate)], C29H28ClFN4O4S2+·2C7H7O3S−, (II), were obtained during crystallization attempts for polymorphism. In both structures, the lapatinib cation is in a distorted U-like conformation and the tosylate anion is clamped between the aniline N atom and methylamine N atom through N—H...O hydrogen bonds, forming anR22(15) ring motif. The 4-anilinoquinazoline ring system is essentially planar in (I), while it is twisted in (II), controlled by an intramolecular C—H...N interaction. In (I), alternating cations and anions are linked by N—H...O hydrogen bonds intoC22(6) chains. These chains are linked by cations in a helical manner. The presence of the additional tosylate anion in (II) results in the formation of one-dimensional tapes of fused hydrogen-bonded rings through N—H...O and C—H...O interactions. These studies augment our understanding of the role of nonbonded interactions in the solid state, which is useful for correlation to the physicochemical properties of drug products.

Organophosphorus-B(C6F5)3 adducts: towards new solid-state emitting materials

2019 ◽  
Vol 48 (34) ◽  
pp. 12803-12807 ◽  
Author(s):  
Elzbieta Regulska ◽  
Sonja Christ ◽  
Johannes Zimmermann ◽  
Frank Rominger ◽  
Gerardo Hernandez-Sosa ◽  
...  
Keyword(s):  
Solid State ◽  
Physicochemical Properties ◽  
Phosphorus Heterocycles

Tuning the physicochemical properties of six-membered phosphorus heterocycles through complexation with B(C6F5)3 towards improved solid-state emitting materials.

scholarly journals A Review on Production of Polygalacturonase Using Various Organisms and Its Applications

2019 ◽  
pp. 1-12
Author(s):  
A. Radha ◽  
R. Sneha ◽  
R. Kiruthiga ◽  
P. Priyadharshini ◽  
N. Prabhu
Keyword(s):  
Solid State ◽  
Physicochemical Properties ◽  
Incubation Period ◽  
Solid State Fermentation ◽  
Full Range ◽  
Carbon Sources ◽  
Oil Extraction ◽  
Hydrolytic Cleavage ◽  
Biotechnological Application ◽  
Pectinolytic Enzyme

Polygalacturonase is a pectinolytic enzyme that catalyses the hydrolytic cleavage of the polygalacturonic linkage chain. An enzyme is a polygalacturonase is expressed in fruits. The polygalacturonase produced from various organisms isolated from various fruits. The solid-state fermentation was used in the production of polygalacturonase. The production of PG was found at various incubation period and pH and temperature are using fruits as best nitrogen and carbon sources. Although they have other parts of the genome they are active in the fruit. Peak expression requires a full range of promoter and saturation lines. Based on the physicochemical properties of the purified enzymes, this enzyme possesses great potential for industrial and biotechnological application such as oil extraction, fruit clarifications.

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