scholarly journals Effect of physical state and particle size distribution on dissolution enhancement of nimodipine/PEG solid dispersions prepared by melt mixing and solvent evaporation

2006 ◽  
Vol 8 (4) ◽  
pp. E623-E631 ◽  
Author(s):  
George Z. Papageorgiou ◽  
Dimitrios Bikiaris ◽  
Evagelos Karavas ◽  
Stavros Politis ◽  
Aristides Docoslis ◽  
...  
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Physical State ◽  
Solid Dispersions ◽  
Solvent Evaporation ◽  
Dissolution Enhancement ◽  
Melt Mixing

Mikroenkapsulasi Atenolol Dengan Penyalut Albumin Menggunakan Metode Penguapan Pelarut

2018 ◽  
Vol 3 (1) ◽  
pp. 19
Author(s):  
Elfia Neswita ◽  
Elfi Sahlan Ben ◽  
Rahmi Nofita
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Active Compound ◽  
Solvent Evaporation ◽  
Solvent Evaporation Method ◽  
Spherical Form ◽  
Coating Agent ◽  
Evaporation Method ◽  
Compound Concentration

<p>Telah dilakukan penelitian tentang mikroenkapsulasi atenolol dengan penyalut albumin menggunakan metode penguapan pelarut dan perbandingan atenolol dengan penyalut albumin yang digunakan adalah 1:1, 1:2 dan 1:3 berturut-turut untuk Formula I, Formula II dan Formula III. Mikrokapsul yang dihasilkan dievaluasi berdasarkan bentuk mikroskopis, distribusi ukuran partikel, penetapan kadar atenolol dalam mikrokapsul dan uji disolusi. Hasil foto mikroskopis menunjukkan mikrokapsul yang dihasilkan berbentuk sferis. Mikrokapsul mempunyai distribusi ukuran partikel 212-2000µm. Data penetapan kadar zat aktif dari masing-masing formula digunakan spektrofotometer UV dengan pelarut metanol dan  diperoleh kadar zat aktif  56,963 ± 17,589; 60,410 ± 1,005; 60,173 ± 1,016 % berturut-turut dalam formula I, Formula II, Formula III. Hasil disolusi menunjukkan bahwa semakin besar konsentrasi albumin pelepasan zat aktif dari mikrokapsul akan semakin diperlambat. Hasil penelitian menunjukkan bahwa mikrokapsul dengan perbandingan antara atenolol dengan albumin 1:1 memiliki pelepasan zat aktif yang paling baik. Kinetika pelepasan bahan aktif dari mikrokapsul mengikuti persamaan Korsmeyer Peppas dan Higuchi</p><p><em>The study about microencapsulation of atenolol with albumen as coating agent and by using solvent evaporation method had be done. The ratio atenolol and albumen were 1:1, 1:2 and 1:3 for Formula I, Formula II and Formula III respectively. The microencapsulation produced was evaluated by measuring microscopic, form particle size distribution, active compound released. The result of photo microscopic showed that microcapsules had spherical form. Microcapsules had particle size distribution between 212-2000 µm. The Spectrophotometer UV in methanol was used to measured the activate compound concentration of microcapsules and was got 56,963 ± 17,589; 60,41 ± 1,0045; 60 and 173 ± 1,0160 % for formula I, Formula II and Formula III. The result of this study showed that microcapsules with comparison between atenolol and albumen 1:1 had better release of active compound. Kinetic of atenolol released from microcapsule followed the Korsmeyer-Peppas and Higuchi.</em></p>

Effects of Particle Size Distribution on Corrosion Rate of Carbon Steel in Soil

2020 ◽  
Vol 69 (4) ◽  
pp. 102-106
Author(s):  
Shota Ohki ◽  
Shingo Mineta ◽  
Mamoru Mizunuma ◽  
Soichi Oka ◽  
Masayuki Tsuda
Keyword(s):  
Particle Size ◽  
Carbon Steel ◽  
Corrosion Rate ◽  
Particle Size Distribution ◽  
Size Distribution

DENSE SPRAY CORRECTIONS FOR DIFFRACTION-BASED PARTICLE SIZE DISTRIBUTION MEASUREMENTS

1995 ◽  
Vol 5 (1) ◽  
pp. 75-87 ◽  
Author(s):  
Christine M. Woodall ◽  
James E. Peters ◽  
Richard O. Buckius
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution

Influence of Cementite Particle Size Distribution on Machinability and Tool Life of High Carbon Cr-bearing Steels

1998 ◽  
Vol 84 (5) ◽  
pp. 387-392 ◽  
Author(s):  
Takashi INOUE ◽  
Yuzo HOSOI ◽  
Koe NAKAJIMA ◽  
Hiroyuki TAKENAKA ◽  
Tomonori HANYUDA
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Tool Life ◽  
Cementite Particle ◽  
High Carbon ◽  
Bearing Steels

Study of the microstructure and particles of vanadium (III) oxide, vanadium (V) oxide and lithium aluminate powders

2020 ◽  
Vol 86 (1) ◽  
pp. 32-37
Author(s):  
Valeria A. Brodskaya ◽  
Oksana A. Molkova ◽  
Kira B. Zhogova ◽  
Inga V. Astakhova
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Vanadium Oxide ◽  
Size Distribution ◽  
Microstructural Analysis ◽  
Coherent Scattering ◽  
Powder Materials ◽  
Lithium Aluminate ◽  
Range Limit ◽  
Oxide Particles

Powder materials are widely used in the manufacture of electrochemical elements of thermal chemical sources of current. Electrochemical behavior of the powders depends on the shape and size of their particles. The results of the study of the microstructure and particles of the powders of vanadium (III), (V) oxides and lithium aluminate obtained by transmission electron and atomic force microscopy, X-ray diffraction and gas adsorption analyses are presented. It is found that the sizes of vanadium (III) and vanadium (V) oxide particles range within 70 – 600 and 40 – 350 nm, respectively. The size of the coherent-scattering regions of the vanadium oxide particles lies in the lower range limit which can be attributed to small size of the structural elements (crystallites). An average volumetric-surface diameter calculated on the basis of the surface specific area is close to the upper range limit which can be explained by the partial agglomeration of the powder particles. Unlike the vanadium oxide particles, the range of the particle size distribution of the lithium aluminate powder is narrower — 50 – 110 nm. The values of crystallite sizes are close to the maximum of the particle size distribution. Microstructural analysis showed that the particles in the samples of vanadium oxides have a rounded (V2O3) or elongated (V2O5) shape; whereas the particles of lithium aluminate powder exhibit lamellar structure. At the same time, for different batches of the same material, the particle size distribution is similar, which indicates the reproducibility of the technologies for their manufacture. The data obtained can be used to control the constancy of the particle size distribution of powder materials.

Sign in / Sign up

Export Citation Format

Share Document