Utilization of chitin as artificial skin

2018 ◽  
pp. 47-52 ◽  
Author(s):  
Se-Kwon Kim
Keyword(s):  
Artificial Skin

Optimization of Extraction Parameters of Reverse Iontophoretic Determination of Blood Glucose in an Artificial Skin Model

2020 ◽  
Vol 16 (6) ◽  
pp. 722-737
Author(s):  
Cigdem Yengin ◽  
Emrah Kilinc ◽  
Fatma Gulay Der ◽  
Mehmet Can Sezgin ◽  
Ilayda Alcin
Keyword(s):  
Ionic Strength ◽  
Body Fluids ◽  
Extraction Time ◽  
Artificial Skin ◽  
Dialysis Membrane ◽  
Skin Model ◽  
Non Invasive ◽  
Electrode Distance ◽  
Experimental Parameters

Background: Reverse İontophoresis (RI) is one of the promising non-invasive technologies. It relies on the transition of low magnitude current through the skin and thus glucose measurement becomes possible as it is extracted from the surface during this porter current flow. Objective: This paper deals with the development and optimization of an RI determination method for glucose. CE dialysis membrane based artificial skin model was developed and the dependence of RI extraction on various experimental parameters was investigated. Method: Dependence of RI extraction performance on noble electrodes (platinum, silver, palladium, ruthenium, rhodium) was checked with CA, CV and DPV, in a wide pH and ionic strength range. Optimizations on inter-electrode distance, potential type and magnitude, extraction time, gel type, membrane MWCO, usage frequency, pretreatment, artificial body fluids were performed. Results: According to the optimized results, the inter-electrode distance was 7.0 mm and silver was the optimum noble metal. Optimum pH and ionic strength were achieved with 0.05M PBS at pH 7.4. Higher glucose yields were obtained with DPV, while CA and CV achieved almost the same levels. During CA, +0.5V achieved the highest glucose yield and higher potential even caused a decrease. Glucose levels could be monitored for 24 hours. CMC gel was the optimum collection media. Pretreated CE membrane with 12kD MWCO was the artificial skin model. Pretreatment affected the yields while its condition caused no significant difference. Except PBS solution (simulated as artificial plasma), among the various artificial simulated body fluids, intestinal juice formulation (AI) and urine formulation U2 were the optimum extraction media, respectively. Conclusion: In this study, various experimental parameters (pretereatment procedure, type and MWCO values of membranes, inter-electrode distance, electrode material, extraction medium solvents, ionic strength and pH, collection medium gel type, extraction potential type and magnitude, extraction time and etc) were optimized for the non-invasive RI determination of glucose in a CE dialysis membrane-based artificial skin model and various simulated artificial body fluids.

Multistimuli‐Responsive Artificial Skin with Dual Output of Photoelectric Signals

2021 ◽  
pp. 2100017
Author(s):  
Lei Li ◽  
Long‐Xiang Cheng ◽  
Liu Yang ◽  
Jun‐Cheng Zhang
Keyword(s):  
Artificial Skin

Study on gelatin-containing artificial skin IV: a comparative study on the effect of antibiotic and EGF on cell proliferation during epidermal healing

Biomaterials ◽  
2001 ◽  
Vol 22 (20) ◽  
pp. 2777-2783 ◽  
Author(s):  
Sung Ran Hong ◽  
Seung Jun Lee ◽  
Jong Won Shim ◽  
Young Seon Choi ◽  
Young Moo Lee ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Comparative Study ◽  
Artificial Skin

Electrical artificial skin using ultraflexible organic transistor

2013 ◽  
Author(s):  
Tsuyoshi Sekitani ◽  
Tomoyuki Yokota ◽  
Makoto Takamiya ◽  
Takayasu Sakurai ◽  
Takao Someya
Keyword(s):  
Artificial Skin ◽  
Organic Transistor

scholarly journals Evaluation of EPS-PCL Nanofibers as a Nanobiocomposite for Artificial Skin Based on Dermal Fibroblast Culture

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Sang-Myung Jung ◽  
Dae Seung Kim ◽  
Jung Hyeon Ju ◽  
Hwa Sung Shin
Keyword(s):  
High Cell Density ◽  
Undaria Pinnatifida ◽  
Dermal Fibroblast ◽  
Bioactive Molecules ◽  
Artificial Skin ◽  
Limited Area ◽  
High Cell ◽  
Electrospinning Technique ◽  
Primary Fibroblasts ◽  
Injured Skin

Several natural bioactive molecules have been used in the development of scaffolds to enhance biocompatibility or biodegradability and macroalgae contain many bioactive compounds that regulate the physiological activities of cells. In this study, extrapolymeric substances (EPS) from brown algae,Undaria pinnatifida, were dispersed in poly-ε-caprolactone (PCL) nanofiber, fabricated by electrospinning technique to mimic natural extracellular matrix (ECM), and tested as a scaffold for the production of artificial skin using rat primary fibroblasts. The level of adhesion, viability, and infiltration of cells on the EPS-PCL nanofibers were then assessed. The primary fibroblasts attached well, had good viability, and infiltrated through the nanofiber mat without cytotoxicity. Additionally, fibroblast on EPS-PCL nanofiber overcame the stress derived from high cell density at limited area. These results indicate that EPS-imbedded nanofiber has the potential to be used as scaffolds to develop artificial skin or as wound-healing nanomedicines to regenerate injured skin.

Artificial Skin for 76–77 GHz Radar Mannequins

2014 ◽  
Vol 62 (11) ◽  
pp. 5671-5679 ◽  
Author(s):  
Ming Chen ◽  
Chi-Chih Chen ◽  
Stanley Y.-P. Chien ◽  
Rini Sherony
Keyword(s):  
Artificial Skin ◽  
77 Ghz
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