Molecular Biology Tools to Boost the Production of Natural Products

2019 ◽  
pp. 71-90
Author(s):  
Samuel Chaves-Silva ◽  
Thamara Ferreira da Silva ◽  
Cristiane Jovelina da-Silva
Keyword(s):  
Natural Products ◽  
Molecular Biology

Comprehensive Natural Products Chemistry Edited by D. H. R. Barton, K. Nakanishi, and O. Meth-Cohn. Elsevier Science:  Oxford, UK. 1999. Nine volumes, $6515.00. ISBN 0-08-042709-X (complete set). Vol. 1, Polyketides and Other Secondary Metabolites Including Fatty Acids and Their Derivatives:  ISBN 0-08-043153-4, pp xl + 1007. Vol. 2, Isoprenoids Including Carotenoids and Steroids:  ISBN 0-08-043154-2, pp xxxviii + 446. Vol. 3, Carbohydrates and Their Derivatives Including Tannins, Cellulose, and Related Lignins: ISBN 0-08-043155-0, pp xl + 939. Vol. 4, Amino Acids, Peptides, Porphyrins, and Alkaloids: ISBN 0-08-043156-9, pp xl + 429. Vol. 5, Enzymes, Enzyme Mechanisms, Proteins, and Aspects of NO Chemistry: ISBN 0-08-043157-7, pp xxxviii + 495. Vol. 6, Prebiotic Chemistry, Molecular Fossils, Nucleosides, and RNA: ISBN 0-08-043158-5, pp xxxviii + 299. Vol. 7, DNA and Aspects of Molecular Biology:  ISBN 0-08-043159-3, pp xxxviii + 733. Vol. 8, Miscellaneous Natural Products Including Marine Natural Products, Pheromones, Plant Hormones, and Aspects of Ecology: ISBN 0-08-043160-7, pp xxxviii + 749. Vol. 9, Cumulative Indexes:  ISBN 0-08-043161-5, pp xxxviii + 351.

1999 ◽  
Vol 121 (29) ◽  
pp. 6971-6972 ◽  
Author(s):  
Philip D. Magnus
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Natural Products ◽  
Molecular Biology ◽  
Secondary Metabolites ◽  
Plant Hormones ◽  
Prebiotic Chemistry ◽  
Molecular Fossils ◽  
Natural Products Chemistry ◽  
Complete Set

Molecular Biology of Plant Natural Products

2006 ◽  
pp. 165-202
Author(s):  
Masilamani Jeyakumar ◽  
V Bhinu ◽  
Leland Cseke ◽  
Sheela Reuben ◽  
Sanjay Swarup ◽  
...  
Keyword(s):  
Natural Products ◽  
Molecular Biology ◽  
Plant Natural Products

Herbicides from Natural Compounds

1987 ◽  
Vol 1 (2) ◽  
pp. 122-128 ◽  
Author(s):  
Stephen O. Duke ◽  
John Lydon
Keyword(s):  
Natural Products ◽  
Molecular Biology ◽  
Butyric Acid ◽  
Higher Plants ◽  
Natural Compounds ◽  
Mechanisms Of Action ◽  
Design And Development ◽  
Wide Range ◽  
Microbial Products

Phytotoxic compounds from plants and microorganisms represent a wide range of chemistries and mechanisms of action that have potential in the design and development of new herbicides. Although several natural products of higher plants have been patented as herbicides, none have been developed commercially. Many microbial products have been patented as herbicides and several have been or are being developed, including bialophos {L-2-amino-4-[(hydroxy)(methyl)phosphinoyl] -butyryl-L-alanyl-L-alanine} and glufosinate [L-2-amino-4-(hydroxyl)(methyl)(phosphinoyl)-butyric acid]. The new tools of molecular biology and biotechnology are making natural products more attractive alternatives in herbicide discovery programs.

Electron Microscopy in Molecular Biology

1967 ◽  
Vol 25 ◽  
pp. 2-3
Author(s):  
Cecil E. Hall
Keyword(s):  
Electron Microscopy ◽  
Molecular Biology ◽  
Noise Level ◽  
Molecular Structures ◽  
Material Structure ◽  
The Arts ◽  
Shadow Casting ◽  
Electron Image ◽  
High Degree ◽  
Very High

The visualization of organic macromolecules such as proteins, nucleic acids, viruses and virus components has reached its high degree of effectiveness owing to refinements and reliability of instruments and to the invention of methods for enhancing the structure of these materials within the electron image. The latter techniques have been most important because what can be seen depends upon the molecular and atomic character of the object as modified which is rarely evident in the pristine material. Structure may thus be displayed by the arts of positive and negative staining, shadow casting, replication and other techniques. Enhancement of contrast, which delineates bounds of isolated macromolecules has been effected progressively over the years as illustrated in Figs. 1, 2, 3 and 4 by these methods. We now look to the future wondering what other visions are waiting to be seen. The instrument designers will need to exact from the arts of fabrication the performance that theory has prescribed as well as methods for phase and interference contrast with explorations of the potentialities of very high and very low voltages. Chemistry must play an increasingly important part in future progress by providing specific stain molecules of high visibility, substrates of vanishing “noise” level and means for preservation of molecular structures that usually exist in a solvated condition.

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