Prebiotic Chemistry That Led to Life

2018 ◽  
pp. 219-233 ◽  
Author(s):  
Juli Peretó
Keyword(s):  
2018 ◽  
Author(s):  
S.M. MacKenzie ◽  
◽  
Elizabeth Turtle ◽  
Ralph Lorenz ◽  
Jani Radebaugh ◽  
...  
Keyword(s):  

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2248
Author(s):  
Lukáš Petera ◽  
Klaudia Mrazikova ◽  
Lukas Nejdl ◽  
Kristyna Zemankova ◽  
Marketa Vaculovicova ◽  
...  

Synthesis of RNA nucleobases from formamide is one of the recurring topics of prebiotic chemistry research. Earlier reports suggest that thymine, the substitute for uracil in DNA, may also be synthesized from formamide in the presence of catalysts enabling conversion of formamide to formaldehyde. In the current paper, we show that to a lesser extent conversion of uracil to thymine may occur even in the absence of catalysts. This is enabled by the presence of formic acid in the reaction mixture that forms as the hydrolysis product of formamide. Under the reaction conditions of our study, the disproportionation of formic acid may produce formaldehyde that hydroxymethylates uracil in the first step of the conversion process. The experiments are supplemented by quantum chemical modeling of the reaction pathway, supporting the plausibility of the mechanism suggested by Saladino and coworkers.


2021 ◽  
Vol 221 ◽  
pp. 103806
Author(s):  
Craig R. Walton ◽  
Oliver Shorttle ◽  
Frances E. Jenner ◽  
Helen M. Williams ◽  
Joshua Golden ◽  
...  
Keyword(s):  

2013 ◽  
Vol 17 (16) ◽  
pp. 1701-1701
Author(s):  
Frank Trixler
Keyword(s):  

ChemInform ◽  
2010 ◽  
Vol 29 (1) ◽  
pp. no-no
Author(s):  
J. D. SUTHERLAND ◽  
J. N. WHITFIELD
Keyword(s):  

Science ◽  
2016 ◽  
Vol 352 (6290) ◽  
pp. 1174-1175 ◽  
Author(s):  
Leroy Cronin ◽  
Sara Imari Walker
Keyword(s):  

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