Advances in Beam Delivery Techniques and Accelerators in Particle Therapy

2018 ◽  
pp. 37-53
Author(s):  
Marco Schippers
Keyword(s):  
Particle Therapy ◽  
Beam Delivery ◽  
Delivery Techniques

PD-0906 A static device for novel fast beam delivery techniques in proton therapy

2021 ◽  
Vol 161 ◽  
pp. S748-S749
Author(s):  
K. Nesteruk ◽  
A. Lomax ◽  
A. Bolsi ◽  
D. Meer ◽  
S. van de Water ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Beam Delivery ◽  
Delivery Techniques

scholarly journals Delivery, Beam and Range Monitoring in Particle Therapy in a Highly Innovative Integrated Design

2020 ◽  
Vol 8 ◽  
Author(s):  
L. Bottura ◽  
E. Felcini ◽  
V. Ferrero ◽  
E. Fiorina ◽  
V. Monaco ◽  
...  
Keyword(s):  
Treatment Plan ◽  
Integrated Design ◽  
Cost Effective ◽  
Target Volume ◽  
Particle Therapy ◽  
Treatment Delivery ◽  
Expected Performance ◽  
Beam Delivery ◽  
Technological Improvements ◽  
System Prototype

The design of a particle therapy system that integrates an innovative beam delivery concept based on a static toroidal gantry and an imaging configuration suitable for beam and online range monitoring is proposed and discussed. Such approach would provide a compact and cost-effective layout, with a highly flexible and fast beam delivery, single particle counting capability for fast measurement of beam fluence and position and a precise real time verification of the compliance between the treatment delivery and its prescription. The gantry configuration is discussed, presenting an analysis of the residual magnetic field in the bore and of the feasibility of irradiating a realistic target volume. Moreover, the expected performance of the PET-based range monitor is assessed through Monte Carlo simulations, showing a precision in the reconstruction of the activity distribution from a clinical treatment plan better than the state-of-the-art devices. The feasibility of the proposed design is then discussed through an assessment of the technological improvements required to actually start the construction and commissioning of a system prototype.

CHARGED PARTICLE THERAPY STEPS INTO THE CLINICAL ENVIRONMENT

2007 ◽  
Vol 16 (04) ◽  
pp. 1205-1220 ◽  
Author(s):  
TH. HABERER
Keyword(s):  
Charged Particle ◽  
Charged Particles ◽  
Basic Research ◽  
Particle Therapy ◽  
Treatment Modalities ◽  
Carbon Ions ◽  
Clinical Environment ◽  
Heavy Charged Particles ◽  
Charged Particle Therapy ◽  
Beam Delivery

Beams of heavy charged particles like protons or carbon ions represent the ideal tool for the treatment of deep-seated, inoperable and radioresistant tumors. For more than 4 decades research with beams of charged particles has been performed. In total more than 40000 patients have been treated, mostly using protons being delivered by accelerators that were designed for basic research centers. In Berkeley, USA heavier particles like helium or neon ions were used to conduct clinical trials until 1992. Based on that somewhat limited technological standard and triggered by the promising results from Berkeley the first dedicated charged particle facilities were constructed. In order to maximally exploit the advantageous physical and radiobiological characteristics of these beams enormous effort was put into developing dynamic beam delivery techniques and tailoring the capabilities of the accelerators, the planning systems and the quality assurance procedures and equipment to the requirements resulting from these new treatment modalities. Active beam delivery systems integrated in rotating gantries, if necessary, will allow the production of superior dose distributions that precisely follow the medical prescription. The technological progress being made during the last 10 years defines the state of the art of the upcoming next-generation facilities for the clinical environment in Europe and Japan.

Beam Delivery Systems for Particle Radiation Therapy: Current Status and Recent Developments

2009 ◽  
Vol 02 (01) ◽  
pp. 179-200 ◽  
Author(s):  
J. M. Schippers
Keyword(s):  
Particle Therapy ◽  
Current Status ◽  
Dose Delivery ◽  
Particle Radiation ◽  
Advantages And Disadvantages ◽  
Future Developments ◽  
Recent Developments ◽  
Beam Delivery ◽  
Beam Delivery System ◽  
Accelerator System

An overview is given of different techniques of dose delivery applied in currently operating and planned particle therapy systems. Their advantages and disadvantages will be compared and consequences of the methods for the rest of the instrumentation will be discussed. The interrelationship between beam delivery at the patient and the accelerator system is shown by means of several concrete examples. Apart from a description of several subsystems in a particle therapy facility, design rules for optimizing the reliability of an accelerator and beam delivery system will be discussed, as well as some remarks concerning how to deal with future developments.

Scan path optimization with/without clustering for active beam delivery in charged particle therapy

2015 ◽  
Vol 31 (2) ◽  
pp. 130-136 ◽  
Author(s):  
Marta F. Dias ◽  
Marco Riboldi ◽  
Joao Seco ◽  
Inês Castelhano ◽  
Andrea Pella ◽  
...  
Keyword(s):  
Charged Particle ◽  
Path Optimization ◽  
Particle Therapy ◽  
Scan Path ◽  
Charged Particle Therapy ◽  
Beam Delivery

scholarly journals Particle therapy in the future of precision therapy

2020 ◽  
Vol 93 (1114) ◽  
pp. 20200183 ◽  
Author(s):  
Lukas Schaub ◽  
Semi Ben Harrabi ◽  
Juergen Debus
Keyword(s):  
Charged Particles ◽  
Clinical Results ◽  
Particle Therapy ◽  
Carbon Ions ◽  
Depth Dose ◽  
Precision Therapy ◽  
Treatment Facilities ◽  
Beam Delivery ◽  
Under Construction ◽  
Number Of Treatment

The first hospital-based treatment facilities for particle therapy started operation about thirty years ago. Since then, the clinical experience with protons and carbon ions has grown continuously and more than 200,000 patients have been treated to date. The promising clinical results led to a rapidly increasing number of treatment facilities and many new facilities are planned or under construction all over the world. An inverted depth–dose profile combined with potential radiobiological advantages make charged particles a precious tool for the treatment of tumours that are particularly radioresistant or located nearby sensitive structures. A rising number of trials have already confirmed the benefits of particle therapy in selected clinical situations and further improvements in beam delivery, image guidance and treatment planning are expected. This review summarises some physical and biological characteristics of accelerated charged particles and gives some examples of their clinical application. Furthermore, challenges and future perspectives of particle therapy will be discussed.

scholarly journals Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

2021 ◽  
Vol 11 ◽  
Author(s):  
Jacinta Yap ◽  
Andrea De Franco ◽  
Suzie Sheehy
Keyword(s):  
Charged Particle ◽  
Particle Therapy ◽  
Treatment Efficiency ◽  
Treatment Indications ◽  
Charged Particle Therapy ◽  
Clinical Benefits ◽  
Accelerator Technology ◽  
Beam Delivery ◽  
And Performance ◽  
Beam Delivery System

The physical and clinical benefits of charged particle therapy (CPT) are well recognized. However, the availability of CPT and complete exploitation of dosimetric advantages are still limited by high facility costs and technological challenges. There are extensive ongoing efforts to improve upon these, which will lead to greater accessibility, superior delivery, and therefore better treatment outcomes. Yet, the issue of cost remains a primary hurdle as utility of CPT is largely driven by the affordability, complexity and performance of current technology. Modern delivery techniques are necessary but limited by extended treatment times. Several of these aspects can be addressed by developments in the beam delivery system (BDS) which determines the overall shaping and timing capabilities enabling high quality treatments. The energy layer switching time (ELST) is a limiting constraint of the BDS and a determinant of the beam delivery time (BDT), along with the accelerator and other factors. This review evaluates the delivery process in detail, presenting the limitations and developments for the BDS and related accelerator technology, toward decreasing the BDT. As extended BDT impacts motion and has dosimetric implications for treatment, we discuss avenues to minimize the ELST and overview the clinical benefits and feasibility of a large energy acceptance BDS. These developments support the possibility of advanced modalities and faster delivery for a greater range of treatment indications which could also further reduce costs. Further work to realize methodologies such as volumetric rescanning, FLASH, arc, multi-ion and online image guided therapies are discussed. In this review we examine how increased treatment efficiency and efficacy could be achieved with improvements in beam delivery and how this could lead to faster and higher quality treatments for the future of CPT.

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