Role of Particle Therapy in Future Radiotherapy Practice

2018 ◽  
pp. 193-201
Author(s):  
Roberto Orecchia
Keyword(s):  
Particle Therapy

scholarly journals [OA044] Quantitative DW-MRI for treatment evaluation in particle therapy: ROLE of ADC maps estimation

2018 ◽  
Vol 52 ◽  
pp. 18-19
Author(s):  
Giulia Buizza ◽  
Chiara Paganelli ◽  
Giulia Fontana ◽  
Andrea Franconeri ◽  
Maria Vittoria Raciti ◽  
...  
Keyword(s):  
Treatment Evaluation ◽  
Particle Therapy

The potential role of borophene as a radiosensitizer in boron neutron capture therapy (BNCT) and particle therapy (PT)

2020 ◽  
Vol 8 (10) ◽  
pp. 2778-2785 ◽  
Author(s):  
Pengyuan Qi ◽  
Qianyuan Chen ◽  
Dong Tu ◽  
Songhuan Yao ◽  
Yupeng Zhang ◽  
...  
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Potential Role ◽  
Particle Therapy ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

The potential role of borophene as a radiosensitizer in PT and BNCT was investigated.

scholarly journals Targeted and Nontargeted α-Particle Therapies

2018 ◽  
Vol 20 (1) ◽  
pp. 73-93 ◽  
Author(s):  
Michael R. McDevitt ◽  
George Sgouros ◽  
Stavroula Sofou
Keyword(s):  
Therapeutic Option ◽  
Particle Therapy ◽  
Clinical Role ◽  
Particle Radiotherapy ◽  
Particle Irradiation ◽  
Effective Use ◽  
Therapy Strategies ◽  
Radiopharmaceutical Therapy

α-Particle irradiation of cancerous tissue is increasingly recognized as a potent therapeutic option. We briefly review the physics, radiobiology, and dosimetry of α-particle emitters, as well as the distinguishing features that make them unique for radiopharmaceutical therapy. We also review the emerging clinical role of α-particle therapy in managing cancer and recent studies on in vitro and preclinical α-particle therapy delivered by antibodies, other small molecules, and nanometer-sized particles. In addition to their unique radiopharmaceutical characteristics, the increased availability and improved radiochemistry of α-particle radionuclides have contributed to the growing recent interest in α-particle radiotherapy. Targeted therapy strategies have presented novel possibilities for the use of α-particles in the treatment of cancer. Clinical experience has already demonstrated the safe and effective use of α-particle emitters as potent tumor-selective drugs for the treatment of leukemia and metastatic disease.

scholarly journals Correction: The potential role of borophene as a radiosensitizer in boron neutron capture therapy (BNCT) and particle therapy (PT)

2021 ◽  
Vol 9 (7) ◽  
pp. 2743-2744
Author(s):  
Pengyuan Qi ◽  
Qianyuan Chen ◽  
Dong Tu ◽  
Songhuan Yao ◽  
Yupeng Zhang ◽  
...  
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Potential Role ◽  
Particle Therapy ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

Correction for ‘The potential role of borophene as a radiosensitizer in boron neutron capture therapy (BNCT) and particle therapy (PT)’ by Pengyuan Qi et al., Biomater. Sci., 2020, 8, 2778–2785, DOI: 10.1039/D0BM00318B.

scholarly journals A Review of Particle Therapy for Skull Base Tumors: Modern Considerations and Future Directions

2021 ◽  
Vol 8 (1) ◽  
pp. 168-178
Author(s):  
Eugen B. Hug ◽  
Maciej Pelak ◽  
Steven J. Frank ◽  
Piero Fossati
Keyword(s):  
Skull Base ◽  
Clinical Investigation ◽  
Particle Therapy ◽  
Future Research ◽  
Benign Tumors ◽  
Skull Base Tumors ◽  
Carbon Ion Therapy ◽  
Ion Therapy ◽  
Future Research Directions

Abstract Skull base tumors constitute one of the established indications for particle therapy, specifically proton therapy. However, a number of prognostic factors, practical clinical management issues, and the emerging role of carbon ion therapy remain subjects of active clinical investigation. This review summarizes these topics, assesses the present status, and reflects on future research directions focusing on the management of chordomas, one of the most aggressive skull base tumors. In addition, the role of particle therapy for benign tumors of the skull base, including pituitary adenoma and acoustic neuroma, is reviewed.

The Role of Particle Therapy for the Treatment of Skull Base Tumors and Tumors of the Central Nervous System (CNS)

2019 ◽  
Vol 28 (2) ◽  
pp. 49-61
Author(s):  
Christian D. Diehl ◽  
Lia M. Halasz ◽  
Jan J. Wilkens ◽  
Anca-Ligia Grosu ◽  
Stephanie E. Combs
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Skull Base ◽  
Particle Therapy ◽  
Skull Base Tumors ◽  
The Central Nervous System

scholarly journals The Role of Particle Therapy in the Risk of Radio-induced Second Tumors: A Review of the Literature

2019 ◽  
Vol 39 (9) ◽  
pp. 4613-4617 ◽  
Author(s):  
ANGELICA FACOETTI ◽  
AMELIA BARCELLINI ◽  
FRANCESCA VALVO ◽  
MARCO PULLIA
Keyword(s):  
Particle Therapy ◽  
Review Of The Literature ◽  
Second Tumors

scholarly journals The role of radiation therapy and particle therapy in renal cell carcinoma: current evidence and future perspectives

2021 ◽  
Author(s):  
Charlien Berghen ◽  
Maarten Albersen ◽  
Robin De Roover ◽  
Kato Rans ◽  
Benoit Beuselinck ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Particle Therapy ◽  
Current Evidence ◽  
Future Perspectives

scholarly journals The Role of Particle Therapy in Adenoid Cystic Carcinoma and Mucosal Melanoma of the Head and Neck

2021 ◽  
Vol 8 (1) ◽  
pp. 273-284
Author(s):  
Daniel K. Ebner ◽  
Timothy D. Malouff ◽  
Steven J. Frank ◽  
Masashi Koto
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Mucosal Melanoma ◽  
Particle Therapy ◽  
Dose Delivery ◽  
Adenoid Cystic ◽  
Particle Irradiation ◽  
Linear Energy Transfer Radiation ◽  
High Linear Energy Transfer

Abstract Particle irradiation is suitable for resistant histologies owing to a combination of improved dose delivery with potential radiobiologic advantages in high linear energy transfer radiation. Within the head and neck, adenoid cystic carcinoma and mucosal melanoma are two such histologies, being radioresistant and lying closely proximal to critical structures. Here, we review the use of particle irradiation for adenoid cystic carcinoma and mucosal melanoma of the head and neck.

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