Chemistry of Cannabis indica

2018 ◽  
pp. 70-75
Author(s):  
Amritpal Singh Saroya
Keyword(s):  
2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Peter Stepaniuk ◽  
Amin Kanani

Abstract Background Cannabis use is growing domestically due to recent legalization in many jurisdictions. There are two main species of cannabis, Cannabis sativa and Cannabis indica, and thousands of different commercially available cannabis strains. Although there are multiple reports of cannabis allergy in the literature, to our knowledge, there is no prior published report of selective cannabis strain allergy. Case presentation A 31-year-old male was referred for allergy assessment due to several episodes of localized pruritus and erythema after direct contact with various strains of cannabis. He had noted that the severity of his reaction appeared to be strain dependent. He developed a severe local reaction involving bilateral periorbital edema shortly after coming into direct contact with one particular strain of cannabis. He denied any adverse symptoms after inhalation of cannabis. Fresh skin prick testing was performed to various strains of cannabis and had positive testing to the three of the five tested strains. Conclusions We believe this is the first reported case of selective cannabis strain allergy based on patient history and skin prick testing. This case report outlines the variability in different strains of cannabis and stresses the importance of further research into cannabis allergen identification. Multiple cannabis allergens should be included and incorporated into commercial extracts when they become routinely available.


The Lancet ◽  
1943 ◽  
Vol 242 (6264) ◽  
pp. 368
Author(s):  
W FOWLER
Keyword(s):  

Author(s):  
R. Ghosh ◽  
A. R. Todd ◽  
S. Wilkinson
Keyword(s):  

2021 ◽  
Vol 20 (2) ◽  
pp. 37-50
Author(s):  
Joseph S. Ashidi ◽  
Irene. E. Emeya ◽  
Folarin O. Owagboriaye ◽  
Roseline T. Feyisola ◽  
Olubukola I. Lawal ◽  
...  

There has been an increasing rate of cannabis consumption globally, especially among the youths. This study therefore evaluated the neurological behaviours and some brain marker hormones and enzymes of cannabis administered rats. Twenty six albino rats were divided into four groups based on oral cannabis administration (control, Cannabis sativa, Cannabis indica and the combination of the two). At the end of seven days, open field test was conducted on the rats. Also, brain neuro-chemicals, activities of antioxidant enzymes and lipid peroxidation were evaluated using spectrophotometry. The results of the Open-Field Test showed an appreciable increase in the level of ambulation (line crossing), grooming, urination and stretched attend posture in the rats administered with Cannabis indica, Cannabis sativa and the combination when compared with the control. Norepinephrine was significantly lower (p < 0.05) in the rat groups administered with the combination of Cannabis indica and Cannabis sativa. The control group however had the lowest dopamine level. Superoxide dismutase (SOD) was significantly lower (p < 0.05) in the rats administered the combination of both Cannabis indica and Cannabis sativa. The brain level of reduced glutathione (GSH) was significantly higher in the rats administered with Cannabis indica. Malondialdehyde (MDA) was significantly higher in the rats administered with Cannabis sativa than the other rat groups. Histopathological evaluation of the brain also revealed various damages in the brain cells of rats administered with cannabis compared to the normal brain structure of the control rats. It is thus said that consumption of C. sativa or C. indica alone produced mild effect on the brain cells and physiology in rats. However, combination of C. sativa and C. indica produced a severe synergistic effect on the neurological function of the exposed rat.


1875 ◽  
Vol 21 (93) ◽  
pp. 78-80
Author(s):  
P. Norton Manning

In the “Practitioner” for January, 1874, the late Dr. Anstie related a case of Epilepsy “cured” by Bromide of Potassium as the solitary instance within his own experience in which well-developed fits were completely stopped and remained absent long after the discontinuance of the medicine, and mentioned that Dr. Hughlings Jackson, whose general experience on this subject was in substantial agreement with his own, had never seen such a case. The combined experience of Dr. Anstie and Dr. Hughlings Jackson must have extended over such a wide field that I do not doubt but that the two following cases, in which Bromide of Potassium, in combination with Cannabis Indica, appeared to “cure” well-marked and established Epilepsy, will be interesting:—


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