Aberrant Methylation of UC Promoters in Human Pancreatic Ductal Carcinomas

2020 ◽  
pp. 151-162
Author(s):  
Michiyo Higashi ◽  
Seiya Yokoyama
Keyword(s):  
Aberrant Methylation ◽  
Ductal Carcinomas

Progressive alteration of DNA methylation of Alu, MGMT, MINT2, and TFPI2 genes in colonic mucosa during colorectal cancer development

2021 ◽  
pp. 1-6
Author(s):  
Ben Kang ◽  
Hyun Seok Lee ◽  
Seong Woo Jeon ◽  
Soo Yeun Park ◽  
Gyu Seog Choi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Healthy Subjects ◽  
Large Scale ◽  
Methylation Status ◽  
Clinical Information ◽  
Field Cancerization ◽  
Aberrant Methylation ◽  
Clinical Value ◽  
Mortality And Morbidity

BACKGROUND: Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity in the world. It is characterized by different pathways of carcinogenesis and is a heterogeneous disease with diverse molecular landscapes that reflect histopathological and clinical information. Changes in the DNA methylation status of colon epithelial cells have been identified as critical components in CRC development and appear to be emerging biomarkers for the early detection and prognosis of CRC. OBJECTIVE: To explore the underlying disease mechanisms and identify more effective biomarkers of CRC. METHODS: We compared the levels and frequencies of DNA methylation in 11 genes (Alu, APC, DAPK, MGMT, MLH1, MINT1, MINT2, MINT3, p16, RGS6, and TFPI2) in colorectal cancer and its precursor adenomatous polyp with normal tissue of healthy subjects using pyrosequencing and then evaluated the clinical value of these genes. RESULTS: Aberrant methylation of Alu, MGMT, MINT2, and TFPI2 genes was progressively accumulated during the normal-adenoma-carcinoma progression. Additionally, CGI methylation occurred either as an adenoma-associated event for APC, MLH1, MINT1, MINT31, p16, and RGS6 or a tumor-associated event for DAPK. Moreover, relatively high levels and frequencies of DAPK, MGMT, and TFPI2 methylation were detected in the peritumoral nonmalignant mucosa of cancer patients in a field-cancerization manner, as compared to normal mucosa from healthy subjects. CONCLUSION: This study identified several biomarkers associated with the initiation and progression of CRC. As novel findings, they may have important clinical implications for CRC diagnostic and prognostic applications. Further large-scale studies are needed to confirm these findings.

scholarly journals Aberrant methylation modifications reflect specific drug responses in small cell lung cancer

Genomics ◽  
2021 ◽  
Vol 113 (3) ◽  
pp. 1114-1126
Author(s):  
Peixin Chen ◽  
Haoyue Guo ◽  
Yu Liu ◽  
Bin Chen ◽  
Sha Zhao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Aberrant Methylation ◽  
Specific Drug ◽  
Small Cell Lung ◽  
Drug Responses

scholarly journals Aberrant methylation ofReprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinoma

Cancer ◽  
2006 ◽  
Vol 107 (2) ◽  
pp. 251-257 ◽  
Author(s):  
Norihiro Sato ◽  
Noriyoshi Fukushima ◽  
Hiroyuki Matsubayashi ◽  
Christine A. Iacobuzio-Donahue ◽  
Charles J. Yeo ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Genetic Instability ◽  
Poor Prognosis ◽  
Ductal Adenocarcinoma ◽  
Aberrant Methylation

RETRACTED: Aberrant methylation of Reprimo in lung cancer

Lung Cancer ◽  
2005 ◽  
Vol 47 (3) ◽  
pp. 309-314 ◽  
Author(s):  
Makoto Suzuki ◽  
Hisayuki Shigematsu ◽  
Takao Takahashi ◽  
Narayan Shivapurkar ◽  
Ubaradka G. Sathyanarayana ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Aberrant Methylation

Aberrant methylation of DNA-damage-inducible transcript 3 promoter is a common event in patients with myelodysplastic syndrome

2010 ◽  
Vol 34 (8) ◽  
pp. 991-994 ◽  
Author(s):  
Jiang Lin ◽  
Ya-li Wang ◽  
Jun Qian ◽  
Dong-ming Yao ◽  
Zhao-hui Zhu ◽  
...  
Keyword(s):  
Dna Damage ◽  
Myelodysplastic Syndrome ◽  
Aberrant Methylation ◽  
Common Event ◽  
Methylation Of Dna
Sign in / Sign up

Export Citation Format

Share Document