The Enteroinsular Axis

2019 ◽  
pp. 41-56
Author(s):  
Varun Pathak ◽  
Nigel Irwin ◽  
Peter R. Flatt
Keyword(s):  
Enteroinsular Axis

The effect of dexamethasone on the enteroinsular axis

1987 ◽  
Vol 47 (5) ◽  
pp. 491-495 ◽  
Author(s):  
P. -H. Groop ◽  
L. C. Groop ◽  
K. J. Totterman ◽  
F. Fyhrquist
Keyword(s):  
Enteroinsular Axis

scholarly journals Effect of massive bowel resection on enteroinsular axis.

Gut ◽  
1979 ◽  
Vol 20 (9) ◽  
pp. 806-810 ◽  
Author(s):  
T Kajawara ◽  
T Szuki ◽  
T Tobe
Keyword(s):  
Bowel Resection ◽  
Enteroinsular Axis ◽  
Massive Bowel Resection

scholarly journals Perinatal short‐chain fructooligosaccharides program intestinal microbiota and improve enteroinsular axis function and inflammatory status in high‐fat diet‐fed adult pigs

2018 ◽  
Vol 33 (1) ◽  
pp. 301-313 ◽  
Author(s):  
Cindy Le Bourgot ◽  
Stéphanie Ferret‐Bernard ◽  
Emmanuelle Apper ◽  
Bernard Taminiau ◽  
Armelle Cahu ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
High Fat Diet ◽  
Short Chain ◽  
High Fat ◽  
Enteroinsular Axis ◽  
Inflammatory Status

Glucose-dependent insulinotropic polypeptide – beyond the enteroinsular axis?

2006 ◽  
Vol 13 (1) ◽  
pp. 56-61
Author(s):  
M Denise Robertson ◽  
Kelly L Johnston ◽  
Linda M Morgan
Keyword(s):  
Enteroinsular Axis

scholarly journals The Role of Sexual Hormones on the Enteroinsular Axis

2019 ◽  
Vol 40 (4) ◽  
pp. 1152-1162 ◽  
Author(s):  
Sandra Handgraaf ◽  
Jacques Philippe
Keyword(s):  
Sex Hormones ◽  
Glucose Homeostasis ◽  
Fine Tuning ◽  
Protective Effects ◽  
Enteroinsular Axis ◽  
Sexual Hormones ◽  
The Impact ◽  
Potential Therapeutics

AbstractSex steroid estrogens, androgens, and progesterone, produced by the gonads, which have long been considered as endocrine glands, are implicated in sexual differentiation, puberty, and reproduction. However, the impact of sex hormones goes beyond these effects through their role on energy metabolism. Indeed, sex hormones are important physiological regulators of glucose homeostasis and, in particular, of the enteroinsular axis. In this review, we describe the roles of estrogens, androgens, and progesterone on glucose homeostasis through their effects on pancreatic α- and β-cells, as well as on enteroendocrine L-cells, and their implications in hormonal biosynthesis and secretion. The analysis of their mechanisms of action with the dissection of the receptors implicated in the several protective effects could provide some new aspects of the fine-tuning of hormonal secretion under the influence of the sex. This knowledge paves the way to the understanding of transgender physiology and new potential therapeutics in the field of type 2 diabetes.

Gastrointestinal Hormones: the Enteroinsular Axis and the Secretion of Glucagon

2015 ◽  
pp. 92-106 ◽  
Author(s):  
J. Dupr� ◽  
Y. Caussignac ◽  
M. Champion ◽  
M. Kobric ◽  
T. J. McDonald ◽  
...  
Keyword(s):  
Gastrointestinal Hormones ◽  
Enteroinsular Axis

Do estrogens participate in the regulation of enteroinsular axis in postmenopausal women?

2003 ◽  
Vol 124 (4) ◽  
pp. A545
Author(s):  
Krystyna Sztefko ◽  
Iwona Rogatko ◽  
Tomasz Milewicz ◽  
Przemyslaw J. Tomasik ◽  
Jozef Krysiek ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Enteroinsular Axis

Insulin and C-Peptide Levels After Oral and Intravenous Glucose: Contribution of Enteroinsular Axis to Insulin Secretion

Diabetes ◽  
1986 ◽  
Vol 35 (5) ◽  
pp. 612-616 ◽  
Author(s):  
S. M. Hampton ◽  
L. M. Morgan ◽  
J. A. Tredger ◽  
R. Cramb ◽  
V. Marks
Keyword(s):  
Insulin Secretion ◽  
Enteroinsular Axis ◽  
Intravenous Glucose ◽  
C Peptide

scholarly journals Equine hyperinsulinemia: investigation of the enteroinsular axis during insulin dysregulation

2016 ◽  
Vol 310 (1) ◽  
pp. E61-E72 ◽  
Author(s):  
M. A. de Laat ◽  
J. M. McGree ◽  
M. N. Sillence
Keyword(s):  
Insulin Secretion ◽  
Attachment Site ◽  
Glucose Absorption ◽  
Oral Glucose ◽  
Enteroinsular Axis ◽  
Insulin Dysregulation ◽  
Before And After ◽  
Glucagon Like Peptide 1 ◽  
Insulin Responsiveness ◽  
Proximal Intestine

Compared with some other species, insulin dysregulation in equids is poorly understood. However, hyperinsulinemia causes laminitis, a significant and often lethal disease affecting the pedal bone/hoof wall attachment site. Until recently, hyperinsulinemia has been considered a counterregulatory response to insulin resistance (IR), but there is growing evidence to support a gastrointestinal etiology. Incretin hormones released from the proximal intestine, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide, augment insulin secretion in several species but require investigation in horses. This study investigated peripheral and gut-derived factors impacting insulin secretion by comparing the response to intravenous (iv) and oral d-glucose. Oral and iv tests were performed in 22 ponies previously shown to be insulin dysregulated, of which only 15 were classified as IR (iv test). In a more detailed study, nine different ponies received four treatments: d-glucose orally, d-glucose iv, oats, and commercial grain mix. Insulin, glucose, and incretin concentrations were measured before and after each treatment. All nine ponies showed similar iv responses, but five were markedly hyperresponsive to oral d-glucose and four were not. Insulin responsiveness to oral d-glucose was strongly associated with blood glucose concentrations and oral glucose bioavailability, presumably driven by glucose absorption/distribution, as there was no difference in glucose clearance rates. Insulin was also positively associated with the active amide of GLP-1 following d-glucose and grain. This study has confirmed a functional enteroinsular axis in ponies that likely contributes to insulin dysregulation that may predispose them to laminitis. Moreover, iv tests for IR are not reliable predictors of the oral response to dietary nonstructural carbohydrate.

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