Optimizing Molecularly Targeted Agents

2017 ◽  
pp. 179-202
Author(s):  
Ying Yuan ◽  
Hoang Q. Nguyen ◽  
Peter F. Thall
Keyword(s):  
Targeted Agents ◽  
Molecularly Targeted Agents

scholarly journals Molecularly profiled trials: toward a framework of actions for the “nil actionables”

2021 ◽  
Author(s):  
Allan Michael Jordan
Keyword(s):  
Holistic Approach ◽  
Step Change ◽  
Additional Patient ◽  
Targeted Agents ◽  
Patient Benefit ◽  
Blood Samples ◽  
Left Behind ◽  
Clinical Community ◽  
Molecularly Targeted Agents ◽  
Early Drug

AbstractThe sequencing of tumour or blood samples is increasingly used to stratify patients into clinical trials of molecularly targeted agents, and this approach has frequently demonstrated clinical benefit for those who are deemed eligible. But what of those who have no clear and evident molecular driver? What of those deemed to have “nil actionable” mutations? How might we deliver better therapeutic opportunities for those left behind in the clamour toward stratified therapeutics? And what significant learnings lie hidden in the data we amass but do not interrogate and understand? This Perspective article suggests a holistic approach to the future treatment of such patients, and sets a framework through which significant additional patient benefit might be achieved. In order to deliver upon this framework, it encourages and invites the clinical community to engage more enthusiastically and share learnings with colleagues in the early drug discovery community, in order to deliver a step change in patient care.

scholarly journals Efficiency of New Dose Escalation Designs in Dose-Finding Phase I Trials of Molecularly Targeted Agents

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e51039 ◽  
Author(s):  
Christophe Le Tourneau ◽  
Hui K. Gan ◽  
Albiruni R. A. Razak ◽  
Xavier Paoletti
Keyword(s):  
Phase I ◽  
Dose Escalation ◽  
Dose Finding ◽  
Phase I Trials ◽  
Targeted Agents ◽  
Molecularly Targeted Agents

scholarly journals Tumor Resistance to Molecularly Targeted Agents

2011 ◽  
Vol 02 (02) ◽  
pp. 258-265 ◽  
Author(s):  
James Chen ◽  
Peter S. Edelstein ◽  
Philip J. Johnson ◽  
Robert Lustig ◽  
Lucien Ooi
Keyword(s):  
Targeted Agents ◽  
Tumor Resistance ◽  
Molecularly Targeted Agents

Specific binding of molecularly targeted agents to pancreas tumors and impact on observed optical contrast

2010 ◽  
Author(s):  
Kimberley S. Samkoe ◽  
Shannon K. Hextrum ◽  
Omar Pardesi ◽  
Julia A. O'Hara ◽  
Tayyaba Hasan ◽  
...  
Keyword(s):  
Specific Binding ◽  
Targeted Agents ◽  
Optical Contrast ◽  
Molecularly Targeted Agents

scholarly journals Assessing the efficacy of molecularly targeted agents on cell line-based platforms by using system identification

BMC Genomics ◽  
2012 ◽  
Vol 13 (S6) ◽  
Author(s):  
Xiangfang Li ◽  
Lijun Qian ◽  
Jianping Hua ◽  
Michael L Bittner ◽  
Edward R Dougherty
Keyword(s):  
System Identification ◽  
Cell Line ◽  
Targeted Agents ◽  
Molecularly Targeted Agents
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