T-Type Ca2+ Channels in Vascular Smooth Muscle

2018 ◽  
pp. 105-121
Author(s):  
Osama F. Harraz ◽  
Ahmed M. Hashad ◽  
Donald G. Welsh
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Ca2 Channels

5-Hydroxytryptamine induces transient Ca2+ influx through Ni2+-insensitive Ca2+ channels in rat vascular smooth muscle cells

1999 ◽  
Vol 380 (2-3) ◽  
pp. 163-170 ◽  
Author(s):  
Masahiko Hirafuji ◽  
Fumito Kawahara ◽  
Takashi Ebihara ◽  
Akihiro Nezu ◽  
Akihiko Tanimura ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Ca2 Channels

scholarly journals Farnesol Inhibits L-type Ca2+Channels in Vascular Smooth Muscle Cells

1997 ◽  
Vol 272 (51) ◽  
pp. 32240-32246 ◽  
Author(s):  
Jean-Baptiste Roullet ◽  
Ulrich C. Luft ◽  
Hong Xue ◽  
Justin Chapman ◽  
Rostislav Bychkov ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Ca2 Channels

scholarly journals Effects of dexmedetomidine on porcine pulmonary artery vascular smooth muscle

2019 ◽  
Author(s):  
Mami Chikuda ◽  
Kenichi Sato
Keyword(s):  
Smooth Muscle ◽  
Pulmonary Artery ◽  
Vascular Smooth Muscle ◽  
Local Anesthetics ◽  
Pulmonary Arteries ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Duration Of Action ◽  
Porcine Pulmonary Artery ◽  
Ca2 Channels

Abstract Background Dexmedetomidine is added to local anesthetics to increase their potency and extend their duration of action, thus providing postoperative analgesia with a single administration. However, the effects and mechanism of action of dexmedetomidine on pulmonary arteries have not been determined. The aim of this study was to investigate the effect of dexmedetomidine on pulmonary artery vascular smooth muscle, evaluating changes in contraction tension. Methods Endothelium-denuded porcine pulmonary arteries were sliced into 2- to 3-mm rings. Changes in isometric contraction tension were measured with the addition of various substances at various concentrations, under different conditions of baseline stimulation (with KCl, Adrenaline, caffeine, or histamine) and different conditions of Ca2+ depletion with intracellular reservoirs or extracellular stores depleted. Results Dexmedetomidine increased the contraction tension induced by high-KCl depolarization in a concentration-dependent manner. Dexmedetomidine inhibited receptor-activated Ca2+ channels (RACCs) and phosphatidylinositol-1,4,5-triphosphate-induced Ca2+ release (IICR), but not Ca2+-induced Ca2+ release (CICR). Conclusions Dex increased the contraction tension resulting from depolarization stimulation by high KCl in a concentration-dependent manner in porcine pulmonary artery vascular smooth muscle. The enhancement of high KCl-induced contraction with Dex addition was mediated by α2 receptors. Dex suppressed increases in contraction tension induced by receptor stimulation with adrenaline, also in a concentration-dependent manner. Dex inhibited RACC and IICR, but not CICR. Elucidating the effects and mechanisms of action of Dex in the central arteries is likely to be useful as basic data for creating Dex-containing local anesthetics.

Direct Block of Ca2+ Channels by Calmidazolium in Cultured Vascular Smooth Muscle Cells

1999 ◽  
Vol 34 (4) ◽  
pp. 488-496 ◽  
Author(s):  
Masanori Sunagawa ◽  
Hisashi Yokoshiki ◽  
Takashi Seki ◽  
Mariko Nakamura ◽  
Patrick Laber ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Ca2 Channels

Alternatively Spliced IS6 Segments of the α1CGene Determine the Tissue-Specific Dihydropyridine Sensitivity of Cardiac and Vascular Smooth Muscle L-Type Ca2+Channels

1997 ◽  
Vol 81 (4) ◽  
pp. 526-532 ◽  
Author(s):  
Andrea Welling ◽  
Andreas Ludwig ◽  
Stephanie Zimmer ◽  
Norbert Klugbauer ◽  
Veit Flockerzi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Tissue Specific ◽  
Alternatively Spliced ◽  
Ca2 Channels

scholarly journals Contraction of vascular smooth muscle by Na+ channel activators: Involvement of Ca2+ channels

1992 ◽  
Vol 58 ◽  
pp. 376
Author(s):  
Masayoshi Shinioh ◽  
Toshio Nakaki ◽  
Yukari Otsuka ◽  
Nobuyuki Sasakawa ◽  
Ryuichi Kato
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Na Channel ◽  
Ca2 Channels
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