Ultraviolet Light, Chromophores, Reactive Oxygen Species, and Human Health

2016 ◽  
pp. 25-40 ◽  
Author(s):  
Shamim Ahmad
Keyword(s):  
Reactive Oxygen Species ◽  
Human Health ◽  
Ultraviolet Light ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals What Did We Accomplish in Fighting Radical Species in Human Health?

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 466
Author(s):  
Rachid Skouta
Keyword(s):  
Reactive Oxygen Species ◽  
Human Health ◽  
Reactive Nitrogen Species ◽  
Reactive Oxygen ◽  
The Body ◽  
Reactive Nitrogen ◽  
Oxygen Species ◽  
Nitrogen Species ◽  
Radical Species ◽  
Physiological Level

Maintaining the physiological level of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the body is highly important in the fight against radical species in the context of human health [...]

scholarly journals Ultraviolet light A irradiation induces immunosuppression associated with the generation of reactive oxygen species in human neutrophils

2016 ◽  
Vol 09 (01) ◽  
pp. 1650001 ◽  
Author(s):  
Cunbo Li ◽  
Xuechen Shi ◽  
Mincai Chen ◽  
Guangxue Xu ◽  
Xinglei Su ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Ultraviolet Light ◽  
Inflammatory Responses ◽  
Reactive Oxygen ◽  
Human Neutrophils ◽  
Oxygen Species ◽  
Immune Functions ◽  
Uva Irradiation ◽  
Underlying Mechanisms

Ultraviolet blood irradiation has been used as a physical therapy to treat many nonspecific diseases in clinics; however, the underlying mechanisms remain largely unclear. Neutrophils, the first line of host defense, play a crucial role in a variety of inflammatory responses. In the present work, we investigated the effects of ultraviolet light A (UVA) on the immune functions of human neutrophils at the single-cell level by using an inverted fluorescence microscope. N-Formyl-methionyl-leucyl-phenylalanine (FMLP), a classic physiological chemotactic peptide, was used to induce a series of immune responses in neutrophils in vitro. FMLP-induced calcium mobilization, migration, and phagocytosis in human neutrophils was significantly blocked after treatment with 365[Formula: see text]nm UVA irradiation, demonstrating the immunosuppressive effects of UVA irradiation on neutrophils. Similar responses were also observed when the cells were pretreated with H2O2, a type of reactive oxygen species (ROS). Furthermore, UVA irradiation resulted in an increase in NAD(P)H, a member of host oxidative stress in cells. Taken together, our data indicate that UVA irradiation results in immunosuppression associated with the production of ROS in human neutrophils.

scholarly journals Asian Dust Particles Induce Macrophage Inflammatory Responses via Mitogen-Activated Protein Kinase Activation and Reactive Oxygen Species Production

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Kazuma Higashisaka ◽  
Maho Fujimura ◽  
Mayu Taira ◽  
Tokuyuki Yoshida ◽  
Shin-ichi Tsunoda ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Human Health ◽  
Inflammatory Responses ◽  
Reactive Oxygen ◽  
Asian Dust ◽  
Dust Particles ◽  
Oxygen Species ◽  
Soil Dust ◽  
Mitogen Activated Protein ◽  
The Impact

Asian dust is a springtime meteorological phenomenon that originates in the deserts of China and Mongolia. The dust is carried by prevailing winds across East Asia where it causes serious health problems. Most of the information available on the impact of Asian dust on human health is based on epidemiological investigations, so from a biological standpoint little is known of its effects. To clarify the effects of Asian dust on human health, it is essential to assess inflammatory responses to the dust and to evaluate the involvement of these responses in the pathogenesis or aggravation of disease. Here, we investigated the induction of inflammatory responses by Asian dust particles in macrophages. Treatment with Asian dust particles induced greater production of inflammatory cytokines interleukin-6 and tumor necrosis factor-α(TNF-α) compared with treatment with soil dust. Furthermore, a soil dust sample containing only particles ≤10 μm in diameter provoked a greater inflammatory response than soil dust samples containing particles >10 μm. In addition, Asian dust particles-induced TNF-αproduction was dependent on endocytosis, the production of reactive oxygen species, and the activation of nuclear factor-κB and mitogen-activated protein kinases. Together, these results suggest that Asian dust particles induce inflammatory disease through the activation of macrophages.

Ultraviolet light induces Stat3 activation in human keratinocytes and fibroblasts through reactive oxygen species and DNA damage

2010 ◽  
Vol 19 (7) ◽  
pp. 654-660 ◽  
Author(s):  
Toshinori Bito ◽  
Naoko Sumita ◽  
Taro Masaki ◽  
Toshiro Shirakawa ◽  
Masato Ueda ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Damage ◽  
Ultraviolet Light ◽  
Reactive Oxygen ◽  
Human Keratinocytes ◽  
Oxygen Species

Reactive oxygen species in human health and disease

Nutrition ◽  
2001 ◽  
Vol 17 (2) ◽  
pp. 161-165 ◽  
Author(s):  
Laura Castro ◽  
Bruce A Freeman
Keyword(s):  
Reactive Oxygen Species ◽  
Human Health ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Health And Disease
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