Introduction to Reactive Oxygen Species: Emphasizing Their Importance in the Male Reproductive System

2016 ◽  
pp. 3-16
Author(s):  
Bongekile Skosana ◽  
Ibukun Oyeyipo ◽  
Stefan Du Plessis
Keyword(s):  
Reactive Oxygen Species ◽  
Reproductive System ◽  
Reactive Oxygen ◽  
Male Reproductive System ◽  
Oxygen Species

scholarly journals Sperm oxidative stress: clinical significance and management

2021 ◽  
pp. 19-27
Author(s):  
S. I. Gamidov ◽  
T. V. Shatylko ◽  
A. Yu. Popova ◽  
N. G. Gasanov ◽  
R. S. Gamidov
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Reproductive System ◽  
Molecular Mechanisms ◽  
Assisted Reproductive Technologies ◽  
Reactive Oxygen ◽  
Reproductive Technologies ◽  
Male Reproductive System ◽  
Antioxidant Systems ◽  
Oxygen Species

Oxidative stress is one of the leading causes of sperm dysfunction. Excessive amounts of reactive oxygen species can damage sperm membranes and disrupt their DNA integrity, which affects not only the likelihood of getting pregnant naturally, but also the clinical outcomes of assisted reproductive technologies and the risk of miscarriage. Sperm cells are extremely vulnerable to oxidative stress, given the limited functional reserve of their antioxidant systems and the DNA repair apparatus. Lifestyle factors, most of which are modifiable, often trigger generation of reactive oxygen species.  Both the lifestyle modification and use of antioxidant dietary supplements are adequate and compatible ways to combat male oxidative stress-associated infertility. The search for other internal and external sources of reactive oxygen species, the identification of the etiology of oxidative stress and treatment of respective diseases are necessary for the successful regulation of redox processes in the male reproductive system in clinical practice, which is required not only to overcome infertility, but also to prevent induced epigenetic disorders in subsequent generations. The article presents the analysis of the molecular mechanisms of male idiopathic infertility. The authors provide an overview of how to prevent oxidative stress as one of the causes of subfebrile fever. The article provides an overview of modern therapeutics, as well as the options for eliminating the consequences of the effect of reactive oxygen species on spermatogenesis and male reproductive system in general.

scholarly journals Impact of reactive oxygen species on antioxidant capacity of male reproductive system

2016 ◽  
Vol 29 (3) ◽  
pp. 421-425 ◽  
Author(s):  
Muhammad Riaz ◽  
Zahed Mahmood ◽  
Muhammad Shahid ◽  
M Usman Qamar Saeed ◽  
Imtiaz Mahmood Tahir ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Antioxidant Capacity ◽  
Reproductive System ◽  
Reactive Oxygen ◽  
Male Reproductive System ◽  
Oxygen Species

Overview and Sources of Reactive Oxygen Species (ROS) in the Reproductive System

2017 ◽  
pp. 1-16
Author(s):  
Gulfam Ahmad ◽  
Mazen Almasry ◽  
Amolak S. Dhillon ◽  
Muna M. Abuayyash ◽  
Narasimhan Kothandaraman ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reproductive System ◽  
Reactive Oxygen ◽  
Oxygen Species

Physiological Roles of Reactive Oxygen Species (ROS) in the Reproductive System

2017 ◽  
pp. 47-64
Author(s):  
Stefan S. du Plessis ◽  
Avi Harlev ◽  
Mohamed Iesar Mohamed ◽  
Eiad Habib ◽  
Narasimhan Kothandaraman ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reproductive System ◽  
Reactive Oxygen ◽  
Oxygen Species

Mitochondria as a source of reactive oxygen species

2009 ◽  
pp. c3 ◽  
Author(s):  
Helena M. Cochemé ◽  
Michael P. Murphy
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species

Clinical aspects of reactive oxygen and nitrogen species

2004 ◽  
Vol 71 ◽  
pp. 121-133 ◽  
Author(s):  
Ascan Warnholtz ◽  
Maria Wendt ◽  
Michael August ◽  
Thomas Münzel
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Risk Factor ◽  
Endothelial Dysfunction ◽  
Vascular Tissue ◽  
Rapid Development ◽  
Reactive Oxygen ◽  
Clinical Aspects ◽  
No Production ◽  
Oxygen Species

Endothelial dysfunction in the setting of cardiovascular risk factors, such as hypercholesterolaemia, hypertension, diabetes mellitus and chronic smoking, as well as in the setting of heart failure, has been shown to be at least partly dependent on the production of reactive oxygen species in endothelial and/or smooth muscle cells and the adventitia, and the subsequent decrease in vascular bioavailability of NO. Superoxide-producing enzymes involved in increased oxidative stress within vascular tissue include NAD(P)H-oxidase, xanthine oxidase and endothelial nitric oxide synthase in an uncoupled state. Recent studies indicate that endothelial dysfunction of peripheral and coronary resistance and conductance vessels represents a strong and independent risk factor for future cardiovascular events. Ways to reduce endothelial dysfunction include risk-factor modification and treatment with substances that have been shown to reduce oxidative stress and, simultaneously, to stimulate endothelial NO production, such as inhibitors of angiotensin-converting enzyme or the statins. In contrast, in conditions where increased production of reactive oxygen species, such as superoxide, in vascular tissue is established, treatment with NO, e.g. via administration of nitroglycerin, results in a rapid development of endothelial dysfunction, which may worsen the prognosis in patients with established coronary artery disease.

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