Guar Gum and Its Derivatives: Versatile Materials for Controlled Drug Delivery

2016 ◽  
pp. 261-287 ◽  
Author(s):  
D Seeli ◽  
M Prabaharan
Keyword(s):  
Drug Delivery ◽  
Guar Gum ◽  
Controlled Drug Delivery

scholarly journals Development and Evaluation of Multilayered Layered Matrix Tablets of Water Soluble Drug

2018 ◽  
Vol 10 (4) ◽  
Author(s):  
Ravi Shekhar ◽  
P. Sharma
Keyword(s):  
Drug Delivery ◽  
Guar Gum ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Zero Order ◽  
Water Soluble ◽  
Matrix Tablets ◽  
Wet Granulation ◽  
Dose Frequency ◽  
Layered Matrix

A new approach to zero- order drug delivery that includes geometric factors is described. Systems such as multilayered tablets and other geometrically altered devices have been created to perform this function. The multi-layered matrix system overcomes inherent disadvantages of non-linearity associated with diffusion controlled matrix devices by providing additional release surface with time to compensate for the decreasing release rate. These formulations designed to deliver the drug at predetermined rate, maintain therapeutically effective concentrations in systemic circulation for prolonged period of time. Recently, pharmaceutical research has focused on controlled drug delivery offer definite advantages over conventional release formulation of the same drug. Controlled delivery systems that can provide zero-order drug delivery have the potential for maximizing efficacy while minimizing dose frequency and toxicity. In the present study, guar gum was used as hydrophilic matrix carrier for designing oral controlled drug delivery systems of highly soluble drug lamivudine. Three layered matrix tablets of lamivudine prepared by wet granulation technique were subjected for various evaluating parameters and optimized.

Guar gum and sesame oil based novel bigels for controlled drug delivery

2014 ◽  
Vol 123 ◽  
pp. 582-592 ◽  
Author(s):  
Vinay K. Singh ◽  
Indranil Banerjee ◽  
Tarun Agarwal ◽  
Krishna Pramanik ◽  
Mrinal K. Bhattacharya ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Guar Gum ◽  
Controlled Drug Delivery ◽  
Sesame Oil

scholarly journals In vivo Evaluation of Theophylline Sustained Release Matrix Tablets Containing Low Viscosity Guar Gum

2021 ◽  
Vol 71 (2) ◽  
Author(s):  
Rama Rao Tadikonda ◽  
Satyanarayana Sreemantula
Keyword(s):  
Drug Delivery ◽  
Guar Gum ◽  
Controlled Drug Delivery ◽  
High Viscosity ◽  
Matrix Tablets ◽  
In Vivo Studies ◽  
Blood Levels ◽  
In Vivo Evaluation ◽  
Low Viscosity

The present investigation was carried out to evaluate the utility of guar gum as a hydrophilic matrix carrier in the design of oral controlled drug delivery. Based on the earlier reports, the low viscosity guar gum appears to be superior to medium and high viscosity grades of guar gum in providing a sustained delivery of theophylline along the GI tract. Conducting in vivo studies on theophylline matrix tablets containing 10% of low viscosity guar gum as a representative formulation assessed the in vivo performance of the guar gum matrix tablets. The in vivo studies were carried out in dogs. The effective concentration of theophylline was sustained for a period of 16 hours. The extended tmax, reduced absorption rate constant, prolonged MRT, unchanged Cmax and unchanged bioavailability indicate a controlled release of theophylline from the guar gum matrix tablets resulting in a sustained absorption and prolonged blood levels of theophylline. The theophylline matrix tablets showed blood levels well below 15 ?g/mL indicating freedom from adverse effects. Based on the studies, guar gum appears to be a potential carrier in the design of oral controlled drug delivery systems.

Formulation of Oral Mucoadhesive Tablets using Mucilage Isolated from Buchanania lanzan spreng Seeds

2014 ◽  
Vol 7 (2) ◽  
pp. 2494-2503
Author(s):  
Sudarshan Singh ◽  
Ayaz Ahmad ◽  
Sunil Bothara B
Keyword(s):  
Drug Delivery ◽  
Guar Gum ◽  
Physical Property ◽  
Flow Property ◽  
Relative Effect ◽  
Losartan Potassium ◽  
In Vitro Dissolution ◽  
Wet Granulation ◽  
Microbial Count

The present study was taken to formulate and evaluate mucilage obtained from Buchanania lanzan spreng seeds (BL) belonging to family anacardiacea for oral mucoadhesive drug delivery system containing losartan potassium. Physiochemical characteristics of mucilage, such as swelling index, microbial count, viscosity, hydration capacity, flow property, and pH were studied. The mucilage was evaluated for its mucoadhesive properties in compressed tablet, containing losartan potassium. Granules were prepared by wet granulation process using polyvinylpyrrolidone as binding agent. Mucilage was used in four different concentrations i.e., 21, 42 and 55% w/w. The tablet were prepared and evaluated for its physical property. Further, in vitro dissolution and swelling index was determined. The property of bioadhesive strength of isolated mucilage was compared with Guar gum and HPMC E5LV, which was used as standard mucoadhesive agent concentration. Bioadhesive strength of the tablet was measured on the modified physical balance. Result revealed that tablets had good physiochemical properties, and drug release was retarded as concentration of mucilage was increased. The force of adhesion was obtained 0.1238N, 0.2822N, 0.5175N, 0.8679N and 0.3983N respectively for F1, F2, F3, F4 and F5. Formulations were subjected for study the effect of agitation at different rpm. Formulation showed relative effect on release of drug from formulation. All the formulations were subjected to stability studies for three months, all formulations showed stability with respect to release pattern. In conclusions, these results indicate that the seed mucilage of BL can be a suitable excipient for oral mucoadhesive drug delivery systems.  

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