Inhibitory effect of Salvia officinalis L. oil on Candida biofilm

2020 ◽  
Vol 25 (1) ◽  
pp. 47
Author(s):  
Huda Ali Hadi ◽  
Rasheed H. Hasan

The present study aimed to investigate the inhibitory effect of alcoholic extract (methanol - ethanol) and flavonoids by diffusion  methods of wells of Salvia officinalis L. and Costus speciosus L. plants on Escherichia . coli and Proteus  spp. isolated from patients with urinary tract infection Samarra city, the samples were collected during the period from 15/7/2018 to 30/9/2018, It was found through the results that the extracts plant that used in this study showed various inhibitory effect against, The bacteria species study imitation , where on differ this effect by difference the concentration that used and type the plant extract , showing  E.coli significant difference at significant (p< 0.05) in inhibition diameter of alcoholic (methanol) extract for Salvia officinalis L. (10.61±7.5) at higher concentration used, while these bacteria showed on significant difference in the level of inhibition diameter of alcoholic (ethanolic) extract for Salvia officinalis L., whereas the flavonoids Netted significant difference of these plant in some of concentration that used comparied with the antibiotic that used in this study. Either regarding proteus spp. bacteria notted no significant difference of both the Costus speciosus L. and Salvia officinalis L. by using the alcoholic (ethanolic) extract, while the flavonoids extract showed no significant difference in Costus speciosus L., whereas showed high significant difference in flavonoids extract of Salvia officinalis  L., due to the fact that the flavonoids extract is one of the active substance that done laboratory extraction for both the plants where that higher inhibitory effect of microbial growth from the alcoholic (ethanolic – methanolic) extract of plants .    http://dx.doi.org/10.25130/tjps.25.2020.009


Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
A Aprotosoaie ◽  
E Gille ◽  
A Spac ◽  
M Gonceariuc ◽  
M Hancianu ◽  
...  

2019 ◽  
Vol 70 (6) ◽  
pp. 2015-2020
Author(s):  
Silvia Robu ◽  
Aurelia Romila ◽  
Olimpia Dumitriu Buzia ◽  
Adrian Florin Spac ◽  
Camelia Diaconu ◽  
...  

Numerous articles on Salvia officinalis L. have been published regarding the composition of their essential oil. The considerable variation found may be due to the quality of the plant material as well as to the methods used for analysis. A simple GC-MS method was developed and optimized in the QbD approach, for the determination of sage essential oils. The optimization of GC-MS analysis was performed using different mobile phase flows, injection volumes, split ratios and temperature programs. The optimized method proved to be simple and can be successfully applied for the determination of sage essential oils.


Author(s):  
Georgiana Uță ◽  
Denisa Ștefania Manolescu ◽  
Speranța Avram

Background.: Currently, the pharmacological management in Alzheimer's disease is based on several chemical structures, represented by acetylcholinesterase and N-methyl-D-aspartate (NMDA) receptor ligands, with still unclear molecular mechanisms, but severe side effects. For this reason, a challenge for Alzheimer's disease treatment remains to identify new drugs with reduced side effects. Recently, the natural compounds, in particular certain chemical compounds identified in the essential oil of peppermint, sage, grapes, sea buckthorn, have increased interest as possible therapeutics. Objectives.: In this paper, we have summarized data from the recent literature, on several chemical compounds extracted from Salvia officinalis L., with therapeutic potential in Alzheimer's disease. Methods.: In addition to the wide range of experimental methods performed in vivo and in vitro, also we presented some in silico studies of medicinal compounds. Results. Through this mini-review, we present the latest information regarding the therapeutic characteristics of natural compounds isolated from Salvia officinalis L. in Alzheimer's disease. Conclusion.: Thus, based on the information presented, we can say that phytotherapy is a reliable therapeutic method in a neurodegenerative disease.


2020 ◽  
Vol 75 (11) ◽  
pp. 1451-1460
Author(s):  
Z. A. Temerdashev ◽  
V. V. Milevskaya ◽  
L. P. Ryabokon’ ◽  
N. N. Latin ◽  
N. V. Kiseleva ◽  
...  

2021 ◽  
Vol 22 (14) ◽  
pp. 7382
Author(s):  
Nancy Chiang ◽  
Shahla Ray ◽  
Jade Lomax ◽  
Sydney Goertzen ◽  
Slavko Komarnytsky ◽  
...  

Culinary sage (Salvia officinalis L.) is a common spice plant in the mint family (Lamiaceae) well known for its distinctive culinary and traditional medicinal uses. Sage tea has been used traditionally as a brain-enhancing tonic and extracts from sage have been reported to have both cognitive and memory enhancing effects. Brain-derived neurotrophic factor (BDNF) is an endogenous signaling molecule involved in cognition and memory function. In this study, activity-guided fractionation employing preparative reverse-phase high performance liquid chromatography (RP-HPLC) of culinary sage extracts led to the discovery of benzyl 6-O-β-D-apiofuranosyl-β-D-glucoside (B6AG) as a natural product that upregulates transcription of neurotrophic factors in C6 glioma cells. Purified B6AG showed a moderate dose response, with upregulation of BDNF and with EC50 at 6.46 μM. To better understand the natural variation in culinary sage, B6AG was quantitated in the leaves of several commercial varieties by liquid chromatography-mass spectrometry (LC-MS). The level of B6AG in dried culinary sage was found to range from 334 ± 14 to 698 ± 65 μg/g. This study provided a foundation for future investigations, including quantitative inquiries on the distribution of B6AG within the different plant organs, explorations in optimizing post-harvest practices, and aid in the development of sage varieties with elevated levels of B6AG.


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