Oxidation 2-(N-Acetylamino)-2-(3,5-Di-Tert-Butyl-4- Hydroxyphenyl)-Propionic Acid by Oxygen in an Alkaline Condition

2016 ◽  
pp. 461-468
Keyword(s):  
Propionic Acid ◽  
Alkaline Condition ◽  
Tert Butyl

scholarly journals Paradoxical Anti-Epileptic Effects of a GluR5 Agonist of Kainate Receptors

2002 ◽  
Vol 88 (1) ◽  
pp. 523-527 ◽  
Author(s):  
Ilgam Khalilov ◽  
June Hirsch ◽  
Rosa Cossart ◽  
Yehezkel Ben-Ari
Keyword(s):  
Propionic Acid ◽  
Therapeutic Approach ◽  
Hippocampal Neurons ◽  
Selective Excitation ◽  
Kainate Receptors ◽  
Kainate Receptor ◽  
Tert Butyl ◽  
Principal Cells ◽  
Selective Agonist

Kainate generates in adult hippocampal neurons a seizure but also a massive excitation of interneurons and a dramatic increase of the inhibitory drive that impinges on principal cells. This “overinhibition” is largely mediated by GluR5-containing kainate receptors that are enriched on interneurons. Here, using the neonatal intact hippocampus in vitro and the triple chamber, we first show that this mechanism is fully operative in neonatal neurons. We then report that application to one hippocampus of ( RS)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid—a relatively selective agonist of GluR5 containing kainate receptors—depresses the propagation of seizure generated in the opposite hippocampus by a convulsive agent. We conclude that the selective excitation of interneurons by GluR5-containing kainate receptor agonists opens a new therapeutic approach for the epilepsies.

Synthesis of (S)-2-Amino-3-(3-tert-butyl-5-oxo-2H-isoxazol-4-yl)propionic Acid

1995 ◽  
Vol 60 (10) ◽  
pp. 3184-3188 ◽  
Author(s):  
Mohamed Atfani ◽  
William D. Lubell
Keyword(s):  
Propionic Acid ◽  
Tert Butyl

Resolution, absolute stereochemistry, and enantiopharmacology of the GluR1-4 and GluR5 antagonist 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid

Chirality ◽  
1999 ◽  
Vol 11 (10) ◽  
pp. 752-759 ◽  
Author(s):  
Eva H. M�ller ◽  
Jan Egebjerg ◽  
Lotte Brehm ◽  
Tine B. Stensb�l ◽  
Tommy N. Johansen ◽  
...  
Keyword(s):  
Propionic Acid ◽  
Tert Butyl ◽  
Absolute Stereochemistry

scholarly journals Effect of Temperature on the Reaction of 2-(N-acetylamine)-3-(3,5-di-<i>tert</i>-butyl-4-hydroxyphenyl)-propionic Acid with Oxygen in an Alkaline Condition

2015 ◽  
Vol 05 (03) ◽  
pp. 262-269
Author(s):  
A. A. Volodkin ◽  
G. E. Zaikov ◽  
L. N. Kurkovskaja ◽  
S. M. Lomakin ◽  
I. M. Levina ◽  
...  
Keyword(s):  
Propionic Acid ◽  
Effect Of Temperature ◽  
Alkaline Condition

Simple chiral auxiliary-assisted resolution of 2-(3,5-di-tert-butyl-4-hydroxyphenyl)propionic acid

2010 ◽  
Vol 20 (5) ◽  
pp. 291-292 ◽  
Author(s):  
Grigory A. Nikiforov ◽  
Orudzh G. Nabiev ◽  
Ivan I. Chervin ◽  
Remir G. Kostyanovsky
Keyword(s):  
Propionic Acid ◽  
Chiral Auxiliary ◽  
Tert Butyl
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